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Serial changes of lung morphology and biochemical profiles in a rat model of bronchopulmonary dysplasia induced by intra-amniotic lipopolysaccharide and postnatal hyperoxia
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Hyun Ju Lee
Veröffentlicht/Copyright:
13. August 2010
Abstract
Aim: To investigate serial changes of lung morphology and biochemical profiles in a rat model of bronchopulmonary dysplasia (BPD) induced by intra-amniotic lipopolysaccharide (LPS) administration and postnatal hyperoxia (85%).
Methods: We evaluated histological changes of the lungs and compared the levels of interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), and protein carbonyl in lung tissue on days 1, 7, and 14 after birth in a rat model of BPD.
Results: The inhibition of alveolarization was sustained in the LPS plus hyperoxia group from day 7 to 14, whereas alveolarization resumed in the hyperoxia group after oxygen exposure was withdrawn at day 7. Administration of LPS alone did not adversely affect lung morphometry. IL-6 levels showed transient overexpression at day 1 in the LPS-treated groups, but decreased at days 7 and 14. VEGF protein levels were elevated in the LPS-treated groups, but not in the hyper-oxia and control groups at days 1, 7, and 14. Exposure to hyperoxia affected protein carbonyl levels in the hyperoxia group at days 7 and 14.
Conclusion: Lung injury induced by intra-amniotic inflammation and postnatal hyperoxia may be due to inhibition of alveolarization without recovery even after withdrawal of oxygen.
Keywords: Bronchopulmonary dysplasia; chorioamnionitis; interleukin-6; protein carbonyl; vascular endothelial growth factor
Received: 2010-2-21
Revised: 2010-4-12
Accepted: 2010-4-28
Published Online: 2010-08-13
Published Online: 2010-08-13
Published in Print: 2010-11-01
©2010 by Walter de Gruyter Berlin New York
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Schlagwörter für diesen Artikel
Bronchopulmonary dysplasia;
chorioamnionitis;
interleukin-6;
protein carbonyl;
vascular endothelial growth factor
Artikel in diesem Heft
- Editorial
- Late motherhood and cesarean delivery
- Review article
- Oxygen and oxidative stress in bronchopulmonary dysplasia
- A statement of the World Association of Perinatal Medicine
- Ethical dimensions of periviability
- Opinion Paper
- The role of melatonin in post-partum psychosis and depression associated with bipolar disorder
- Original articles – Obstetrics
- Low maternal serum matrix metalloproteinase (MMP)-2 concentrations are associated with preterm labor and fetal inflammatory response
- Comparison of complications in second trimester amniocentesis performed with 20G, 21G and 22G needles
- Genome profiles in maternal blood during early onset preeclampsia and towards term
- Comparative analysis of insulin-like growth factor binding protein-1 (IGFBP-1), placental alpha-microglobulin-1 (PAMG-1) and nitrazine test to diagnose premature rupture of membranes in pregnancy
- Evidence of the escape of antithrombin from the blood into the interstitial space in pregnant women
- Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term
- Does very advanced maternal age, with or without egg donation, really increase obstetric risk in a large tertiary center?
- A great lack of knowledge regarding umbilical cord blood banking among pregnant women in Berlin, Germany
- Long chain polyunsaturated fatty acids in mothers of preterm babies
- Original articles – Fetus
- The expression pattern of two novel cytokines (IL-24 and IL-29) in human fetal membranes
- The source of error in the estimation of intertwin birth weight discordance
- Original articles – Newborn
- Serial changes of lung morphology and biochemical profiles in a rat model of bronchopulmonary dysplasia induced by intra-amniotic lipopolysaccharide and postnatal hyperoxia
- Effect of prenatal tobacco smoke exposure on fetal growth potential
- Prenatal tobacco exposure and cortisol levels in infants of teen mothers
- Letter to the editor
- Mediastinal tumor during pregnancy: a multidisciplinary approach
- Neonatal abstinence syndrome (NAS) after intrauterine exposure to tramadol
- Fetoscopic laser photocoagulation and uterine wall defects
- Congress Calendar
- Congress Calendar
