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The effect of advanced maternal age on perinatal outcomes in nulliparous pregnancies

  • Gülhan Elçi ORCID logo , Ayşegül Çakmak ORCID logo , Erkan Elçi ORCID logo EMAIL logo und Sena Sayan ORCID logo
Veröffentlicht/Copyright: 13. Mai 2022
Journal of Perinatal Medicine
Aus der Zeitschrift Journal of Perinatal Medicine Band 50 Heft 8

Abstract

Objectives

In the current study, we aimed to evaluate the effect of advanced maternal age on perinatal outcomes in nulliparous singleton pregnancy.

Methods

The perinatal outcome data of 11,366 patients who gave birth between 2015 and 2020 were evaluated retrospectively. Patients were subgrouped according to their age as control group (C) (20–29 years), late advanced maternal age group (30–34 years), advanced maternal age group (35–39 years), and very advanced maternal age group (≥40 years). Multinomial logistic regression analyses were performed to test the possible independent role of maternal age as a risk factor for adverse pregnancy outcomes.

Results

Statistically significant difference was observed between the control group and the other groups in terms of preterm delivery, preeclampsia, gestational diabetes mellitus (GDM), small gestational age (SGA), large gestational age (LGA), premature rupture of membranes (PROM), high birth weight (HBW), and perinatal mortality rates (p<0.05). An increased risk of the need for neonatal intensive care unit (NICU) and perinatal mortality was observed in groups over 35 years old.

Conclusions

Age poses a risk in terms of preterm delivery, preeclampsia, LGA, GDM, and HBW in the groups over 30 years of maternal age. The rates of PROM, NICU, and perinatal mortality increase in addition to those perinatal results in the groups above 35 years of maternal age.

Keywords: advanced maternal age; maternal age; nulliparity; perinatal outcomes; pregnancy outcomes
Corresponding author: Erkan Elçi, MD, Department of Obstetrics and Gynecology, University of Health Sciences Umraniye Training and Research Hospital, Istanbul, Turkey, Adem Yavuz, Str No 01, Elmalıkent, Umraniye, Postal zip Code: 34070, Istanbul, Turkey, Phone: +90 506 484 5469, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was not required because of the retrospective nature of the study; the research involves no more than minimal risk to the subjects and the waiver will not adversely affect the rights and welfare of the subjects.

  5. Ethical approval: Ethical approval was received from the local Ethics Committee (approval number: 11/02/2021-14).

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Received: 2021-06-17
Accepted: 2022-04-01
Published Online: 2022-05-13
Published in Print: 2022-10-26

© 2022 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. WAPM Guideline
  3. Ultrasound in labor: clinical practice guideline and recommendation by the WAPM-World Association of Perinatal Medicine and the PMF-Perinatal Medicine Foundation
  4. Original Articles – Obstetrics
  5. Racial and ethnic distribution of US randomized controlled trials in obstetrics: a retrospective review
  6. Impact of earlier gestational diabetes screening for pregnant people with obesity on maternal and perinatal outcomes
  7. Variations in uterine closure technique: an institutional survey of obstetricians and implications for patient counseling and prevention of adverse sequelae
  8. Termination of pregnancy in the second trimester – the course of different therapy regimens
  9. Hyponatremia among preeclampsia patients – a potential sign of severity
  10. Effect of combined paracetamol and dexamethasone vs. paracetamol on postoperative nausea vomiting after cesarean section
  11. Lidocaine vs. tramadol vs. placebo wound infiltration for post-cesarean section pain relief: a randomized controlled trial
  12. Does the use of chitosan covered gauze for postpartum hemorrhage reduce the need for surgical therapy including hysterectomy? A databased historical cohort study
  13. The effect of advanced maternal age on perinatal outcomes in nulliparous pregnancies
  14. Evaluating the correlation between amniotic fluid volume and estimated fetal weight in healthy pregnant women
  15. Metabolic characterization of amniotic fluid of fetuses with isolated choroid plexus cyst
  16. Does a cervical pessary reduce the rate of preterm birth in women with a short cervix?
  17. Research progress on N6-methyladenosine in the human placenta
  18. Why are women deciding against birth in alongside midwifery units? A prospective single-center study from Germany
  19. Pregnancy hypothyroidism incidence and complications using the 2011 and 2017 ATA cutoff values. Experience at a maternity hospital in a densely populated area in Mexico City
  20. Expression pattern and clinical significance of microRNA-let-7a and IFN-gamma in placental tissue of patients with preeclampsia with severe features
  21. Original Articles – Fetus
  22. Management of neonates with 35 weeks of gestational age or more with infectious risk factors at birth: opportunities for improvement
https://doi.org/10.1515/jpm-2021-0298
Schlagwörter für diesen Artikel
advanced maternal age; maternal age; nulliparity; perinatal outcomes; pregnancy outcomes

Artikel in diesem Heft

  1. Frontmatter
  2. WAPM Guideline
  3. Ultrasound in labor: clinical practice guideline and recommendation by the WAPM-World Association of Perinatal Medicine and the PMF-Perinatal Medicine Foundation
  4. Original Articles – Obstetrics
  5. Racial and ethnic distribution of US randomized controlled trials in obstetrics: a retrospective review
  6. Impact of earlier gestational diabetes screening for pregnant people with obesity on maternal and perinatal outcomes
  7. Variations in uterine closure technique: an institutional survey of obstetricians and implications for patient counseling and prevention of adverse sequelae
  8. Termination of pregnancy in the second trimester – the course of different therapy regimens
  9. Hyponatremia among preeclampsia patients – a potential sign of severity
  10. Effect of combined paracetamol and dexamethasone vs. paracetamol on postoperative nausea vomiting after cesarean section
  11. Lidocaine vs. tramadol vs. placebo wound infiltration for post-cesarean section pain relief: a randomized controlled trial
  12. Does the use of chitosan covered gauze for postpartum hemorrhage reduce the need for surgical therapy including hysterectomy? A databased historical cohort study
  13. The effect of advanced maternal age on perinatal outcomes in nulliparous pregnancies
  14. Evaluating the correlation between amniotic fluid volume and estimated fetal weight in healthy pregnant women
  15. Metabolic characterization of amniotic fluid of fetuses with isolated choroid plexus cyst
  16. Does a cervical pessary reduce the rate of preterm birth in women with a short cervix?
  17. Research progress on N6-methyladenosine in the human placenta
  18. Why are women deciding against birth in alongside midwifery units? A prospective single-center study from Germany
  19. Pregnancy hypothyroidism incidence and complications using the 2011 and 2017 ATA cutoff values. Experience at a maternity hospital in a densely populated area in Mexico City
  20. Expression pattern and clinical significance of microRNA-let-7a and IFN-gamma in placental tissue of patients with preeclampsia with severe features
  21. Original Articles – Fetus
  22. Management of neonates with 35 weeks of gestational age or more with infectious risk factors at birth: opportunities for improvement
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