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Fertility treatment and dichorionic discordant twins – are they related?

  • Tal Biron-Shental EMAIL logo , Ariel Many , Amir Wiser , Gil Shechter-Maor , Rivka Sukenik-Halevy und Arie Berkovitz
Veröffentlicht/Copyright: 5. November 2015
Journal of Perinatal Medicine
Aus der Zeitschrift Journal of Perinatal Medicine Band 44 Heft 8

Abstract

Objective:

This prospective cohort study evaluated the relationship between fertility treatments and the prevalence and outcomes of dichorionic discordant twins. This issue has gained importance due to twin gestations resulting from fertility treatments.

Study design:

Mothers of dichorionic twin pregnancies achieved in a single fertility clinic by assisted reproduction techniques, who had completed the first trimester of the pregnancy, were prospectively enrolled. Pregnancies with major fetal anomalies were excluded. Data regarding concordant and discordant twins based on the fertility treatments given to achieve the pregnancies were analyzed to determine the prevalence of discordance and pregnancy outcomes.

Results:

A total of 571 dichorionic twin pregnancies were available for evaluation. Fertility treatments modalities, sperm quality and implantation of cultured and thawed embryos did not influence the rate and severity of discordant twins. Increased hospitalization rates were found among discordant (n=108) compared to concordant (n=463) twins (47.2% vs. 31.3%, P<0.0001) and higher rates of betamethasone treatment (65.7% vs. 28.9%, P<0.0001). Secondary analysis of discordant pregnancies with a growth restricted twin, revealed the same results. We found no association between various fertility treatments and twin discordance.

Conclusions:

Our data suggest that fertility treatments do not play a major role in the pervasiveness and outcome of discordant twin pregnancies.

Keywords: Fertility treatments; twin discordant
Corresponding author: Tal Biron-Shental, MD, Department of Obstetrics and Gynecology, Meir Medical Center, 59 Tschernihovsky, Kfar Saba 44282 Israel; and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, Tel.: +972-528362331, E-mail:

Acknowledgments

We would like to Acknowledge Mrs. Faye Schreiber for the English language editing.

  1. Condensation: Fertility treatments modalities, sperm quality and implantation of cultured and thawed embryos do not influence the rate, severity and outcome of discordant dichorionic twin pregnancies.

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  1. The authors stated that there are no conflicts of interest regarding the publication of this article.

Received: 2015-7-17
Accepted: 2015-10-5
Published Online: 2015-11-5
Published in Print: 2016-11-1

©2016 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Multiple gestation: more research challenges to come
  4. Highlight articles - Multiples
  5. Fertility treatment and dichorionic discordant twins – are they related?
  6. Intertwin estimated fetal weight or crown rump length discordance and adverse perinatal outcome
  7. Prospective risk of intrauterine death of monochorionic twins: update
  8. Perinatal outcome of dichorionic-triamniotic as compared to trichorionic triplets
  9. Outcome of monochorionic-biamniotic twins conceived by assisted reproduction: a population-based study
  10. Neonatal morbidities and need for intervention in twins and singletons born at 34–35 weeks of gestation
  11. Glucose tolerance in singleton, twin and triplet pregnancies
  12. Respiratory morbidity in twins by birth order, gestational age and mode of delivery
  13. Neonatal outcomes of twin pregnancies delivered at late-preterm versus term gestation based on chorionicity and indication for delivery
  14. Original papers - Newborn
  15. Congenital diaphragmatic hernia – a Belgrade single center experience
  16. Iron homeostasis after blood transfusion in stable preterm infants – an observational study
  17. Detection and quantification of left-to-right shunting using transpulmonary ultrasound dilution (TPUD): a validation study in neonatal lambs
  18. Clinical utility of transcutaneous bilirubinometer (TcB) in very low birth weight (VLBW) infants
  19. Outcome of small for gestational age preterm singletons: a population-based cohort study
  20. Congress Calendar
  21. Congress Calendar
https://doi.org/10.1515/jpm-2015-0231
Schlagwörter für diesen Artikel
Fertility treatments; twin discordant

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Multiple gestation: more research challenges to come
  4. Highlight articles - Multiples
  5. Fertility treatment and dichorionic discordant twins – are they related?
  6. Intertwin estimated fetal weight or crown rump length discordance and adverse perinatal outcome
  7. Prospective risk of intrauterine death of monochorionic twins: update
  8. Perinatal outcome of dichorionic-triamniotic as compared to trichorionic triplets
  9. Outcome of monochorionic-biamniotic twins conceived by assisted reproduction: a population-based study
  10. Neonatal morbidities and need for intervention in twins and singletons born at 34–35 weeks of gestation
  11. Glucose tolerance in singleton, twin and triplet pregnancies
  12. Respiratory morbidity in twins by birth order, gestational age and mode of delivery
  13. Neonatal outcomes of twin pregnancies delivered at late-preterm versus term gestation based on chorionicity and indication for delivery
  14. Original papers - Newborn
  15. Congenital diaphragmatic hernia – a Belgrade single center experience
  16. Iron homeostasis after blood transfusion in stable preterm infants – an observational study
  17. Detection and quantification of left-to-right shunting using transpulmonary ultrasound dilution (TPUD): a validation study in neonatal lambs
  18. Clinical utility of transcutaneous bilirubinometer (TcB) in very low birth weight (VLBW) infants
  19. Outcome of small for gestational age preterm singletons: a population-based cohort study
  20. Congress Calendar
  21. Congress Calendar
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