Iron homeostasis after blood transfusion in stable preterm infants – an observational study
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Jacky Herzlich
Abstract
Aim:
To evaluate the short-term effects of blood transfusion on iron status [hemoglobin, ferritin, soluble transferrin receptor (sTfR), and reticulocyte count], hepcidin, and erythropoietin in stable preterm infants.
Method:
Sixty-three preterm infants treated with red blood cell transfusions (RBCTs) were included. Venous blood samples were collected before and within 24 h after each transfusion.
Results:
Hemoglobin concentration increased after RBCT (7.2±1.2 g/dL vs. 13.7±2.3 g/dL, P=0.02), as well as ferritin [131 (63–110.4) ng/mL vs. 211 (125.7–299.2) ng/mL, P=0.05); reticulocyte count decreased. sTfR did not change. Hepcidin serum levels increased from 37.5 (21.3–84.7) ng/mL to 72.6 (31.3–126.2) ng/mL, (P=0.04) and erythropoietin decreased (48±19 pg/mL vs. 29±17 pg/mL, P=0.06) after RBCT. A positive linear correlation was found (R2=0.76, P=0.0001) between hepcidin and ferritin levels of post-minus-pre RBCT. Hepcidin levels increased significantly in preterm infants who received RBCT after 1 month of age compared to those who received RBCT at <1 month (P=0.03). No correlation was found between gestational age, weight appropriate for age, or length of blood storage and hepcidin levels.
Conclusion:
Preterm infants can control iron levels by regulating hepcidin and decreasing erythropoietin. This ability varies with postnatal age.
Acknowledgments
This study was not supported by external funding.
References
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The authors stated that there are no conflicts of interest regarding the publication of this article.
©2016 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Editorial
- Multiple gestation: more research challenges to come
- Highlight articles - Multiples
- Fertility treatment and dichorionic discordant twins – are they related?
- Intertwin estimated fetal weight or crown rump length discordance and adverse perinatal outcome
- Prospective risk of intrauterine death of monochorionic twins: update
- Perinatal outcome of dichorionic-triamniotic as compared to trichorionic triplets
- Outcome of monochorionic-biamniotic twins conceived by assisted reproduction: a population-based study
- Neonatal morbidities and need for intervention in twins and singletons born at 34–35 weeks of gestation
- Glucose tolerance in singleton, twin and triplet pregnancies
- Respiratory morbidity in twins by birth order, gestational age and mode of delivery
- Neonatal outcomes of twin pregnancies delivered at late-preterm versus term gestation based on chorionicity and indication for delivery
- Original papers - Newborn
- Congenital diaphragmatic hernia – a Belgrade single center experience
- Iron homeostasis after blood transfusion in stable preterm infants – an observational study
- Detection and quantification of left-to-right shunting using transpulmonary ultrasound dilution (TPUD): a validation study in neonatal lambs
- Clinical utility of transcutaneous bilirubinometer (TcB) in very low birth weight (VLBW) infants
- Outcome of small for gestational age preterm singletons: a population-based cohort study
- Congress Calendar
- Congress Calendar
Artikel in diesem Heft
- Frontmatter
- Editorial
- Multiple gestation: more research challenges to come
- Highlight articles - Multiples
- Fertility treatment and dichorionic discordant twins – are they related?
- Intertwin estimated fetal weight or crown rump length discordance and adverse perinatal outcome
- Prospective risk of intrauterine death of monochorionic twins: update
- Perinatal outcome of dichorionic-triamniotic as compared to trichorionic triplets
- Outcome of monochorionic-biamniotic twins conceived by assisted reproduction: a population-based study
- Neonatal morbidities and need for intervention in twins and singletons born at 34–35 weeks of gestation
- Glucose tolerance in singleton, twin and triplet pregnancies
- Respiratory morbidity in twins by birth order, gestational age and mode of delivery
- Neonatal outcomes of twin pregnancies delivered at late-preterm versus term gestation based on chorionicity and indication for delivery
- Original papers - Newborn
- Congenital diaphragmatic hernia – a Belgrade single center experience
- Iron homeostasis after blood transfusion in stable preterm infants – an observational study
- Detection and quantification of left-to-right shunting using transpulmonary ultrasound dilution (TPUD): a validation study in neonatal lambs
- Clinical utility of transcutaneous bilirubinometer (TcB) in very low birth weight (VLBW) infants
- Outcome of small for gestational age preterm singletons: a population-based cohort study
- Congress Calendar
- Congress Calendar