Adrenal oncocytoma: an unusual etiology of Cushing’s syndrome in an adolescent female
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Saba Samad Memon
,
Sanjay Chaudhari
,
Zalak Parmar
,
Kaushal Patel
Abstract
Objectives
This report presents a rare pediatric functional AO causing CS and androgen excess. It aims to discuss the diagnostic challenges of cortisol and DHEAS co-secretion, which may mimic adenomas or carcinomas. It also emphasizes the role of clinical, biochemical, and imaging assessments, as well as histological classification using LWB criteria, and the need for long-term follow-up.
Case presentation
A 17-year-old female presented with weight gain, moon facies, cushingoid striae, oligomenorrhea, and acne over six months. Examination showed hypertension, grade I obesity, cushingoid stigmata without virilization. Endocrine evaluation was confirmed ACTH independent CS due to right AO.
Conclusions
This case illustrates functional AO as a rare cause of adolescent CS with androgen excess. Co-secretion patterns complicate diagnosis, imaging may not be definitive, and long-term follow-up is vital due to uncertain prognosis.
Acknowledgments
Ms. Palak Raj-helped in retrieving the case details and prepare the manuscript.
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Research ethics: Not applicable.
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Informed consent: Informed consent was obtained from their legal guardians.
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Author contributions: The authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Use of Large Language Models, AI and Machine Learning Tools: Not applicable.
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Conflict of interest: The authors state no conflict of interest.
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Research funding: None declared.
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Data availability: Not applicable.
References
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© 2025 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Review
- Prevalence of congenital hypothyroidism in infants of mothers with hypothyroidism: a meta-analysis
- Original Articles
- Pubertal characteristics, final height, and associated factors in patients with nonclassical congenital adrenal hyperplasia: a single center experience
- Serum α-Klotho and its association with testosterone in boys with central precocious puberty
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- The relationship between FSTL-1 (follistatin-related protein 1), FAM19A5 (family with sequence similarity 19, member A5) and CTRP-6 (C1q/TNF-related protein 6) levels and metabolic parameters in overweight children
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- Characterization of monogenic diabetes among Sudanese children: a multi-center experience from a population with high consanguinity
- Short Communication
- Implementation and feasibility of a nutrition assessment for recently diagnosed youth with type 2 diabetes
- Case Reports
- Noonan syndrome and autoimmune hepatitis: patient report and literature review
- Adrenal oncocytoma: an unusual etiology of Cushing’s syndrome in an adolescent female
- Novel MCT8 mutation: diagnostic value of T3/T4 ratio
- Clinical insights of the TBX19 C.856 C>T variant: a case report and literature review on neonatal isolated ACTH deficiency
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Artikel in diesem Heft
- Frontmatter
- Review
- Prevalence of congenital hypothyroidism in infants of mothers with hypothyroidism: a meta-analysis
- Original Articles
- Pubertal characteristics, final height, and associated factors in patients with nonclassical congenital adrenal hyperplasia: a single center experience
- Serum α-Klotho and its association with testosterone in boys with central precocious puberty
- Bioelectrical impedance analysis and hormonal assessment in adolescents with pubertal gynecomastia
- The relationship between FSTL-1 (follistatin-related protein 1), FAM19A5 (family with sequence similarity 19, member A5) and CTRP-6 (C1q/TNF-related protein 6) levels and metabolic parameters in overweight children
- Role of hyperandrogenism on disordered eating behaviors in adolescents with PCOS and interplay with insulin resistance
- The impact of hepatic steatosis on epicardial adipose tissue in obese individuals
- Exploratory real-world experience with GLP-1 receptor agonists vs. metformin in youth with new-onset type 2 diabetes: a single-center retrospective study
- Characterization of monogenic diabetes among Sudanese children: a multi-center experience from a population with high consanguinity
- Short Communication
- Implementation and feasibility of a nutrition assessment for recently diagnosed youth with type 2 diabetes
- Case Reports
- Noonan syndrome and autoimmune hepatitis: patient report and literature review
- Adrenal oncocytoma: an unusual etiology of Cushing’s syndrome in an adolescent female
- Novel MCT8 mutation: diagnostic value of T3/T4 ratio
- Clinical insights of the TBX19 C.856 C>T variant: a case report and literature review on neonatal isolated ACTH deficiency
- Wolcott–Rallison syndrome due to a novel homozygous missense variation (p.Gly602Val) in the exon 11 of EIF2AK3 gene
