Startseite Ameliorative effect of Kolaviron, an extract of Garcinia kola seeds, on induced hypertension
Artikel
Lizenziert
Nicht lizenziert Erfordert eine Authentifizierung

Ameliorative effect of Kolaviron, an extract of Garcinia kola seeds, on induced hypertension

  • Francis J. Olatoye ORCID logo , Abidemi J. Akindele ORCID logo EMAIL logo und Samson Onwe
Veröffentlicht/Copyright: 11. Mai 2021
Journal of Complementary and Integrative Medicine
Aus der Zeitschrift Journal of Complementary and Integrative Medicine Band 19 Heft 1

Abstract

Objectives

Early diagnosis and management of known cardiovascular disease risk attributes such as hypertension lessens morbidity and mortality as well as increase quality of life of patients. This present study was modelled to investigate the ameliorative effect of Kolaviron, an extract of Garcinia kola Heckel seeds, in ethanol- and sucrose-induced hypertension.

Methods

Test animals were divided into six groups of six animals each for each hypertensive model. Animals were treated daily with distilled water (10 ml/kg); 35% ethanol (3 g/kg) or sucrose (5–7%); Kolaviron (50, 100 and 200 mg/kg) separately plus ethanol or sucrose and Amlodipine (0.14 mg/kg) separately plus ethanol or sucrose for 8 weeks. Systolic, diastolic and mean arterial pressures were determined using non-invasive BP system after 8 weeks. Blood was obtained for the assessment of biochemical parameters, lipid profile and antioxidant indices. Vital organs were collected for approximation of tissue antioxidant levels.

Results

Results show that Kolaviron at various doses and Amlodipine significantly reduced (p<0.05–0.001) the elevated systolic, diastolic, and mean arterial pressures produced by ethanol and sucrose administration. Additionally, Kolaviron and Amlodipine significantly overturned (p<0.05–0.001) the reduction in GSH, SOD and CAT, and elevation in MDA levels elicited by ethanol and sucrose. Furthermore, Kolaviron and Amlodipine produced significant reduction (p<0.001) in levels of cholesterol, triglycerides and low-density lipoproteins, as well as significant increase (p<0.01–0.001) in levels of high-density lipoproteins.

Conclusions

Results from this study demonstrate that Kolaviron possibly possesses significant antihypertensive effect which may possibly be attributed to its antioxidant effects and relative improvement of lipid profile.

Keywords: antihypertensive; antioxidant; cardiovascular diseases; Garcinia kola ; hypertension; Kolaviron
Corresponding author: Dr. Abidemi J. Akindele, PhD, Associate Professor, Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Idi-Araba, P.M.B. 12003, Lagos, Nigeria, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: None declared.

  4. Employment or leadership: None declared.

  5. Honorarium: None declared.

  6. Ethical approval: This research was approved by the Health Research Ethics Committee, College of Medicine, University of Lagos, Nigeria (CMUL/HREC/10/19/656) and was in accordance with the provisions of the United States National Academy of Sciences Guide for the Care and Use of Laboratory Animals.

References

1. World Health Organization. World Health Organisation key facts on cardiovascular diseases (CVDs). WHO Fact Sheets; 2017. https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds).Suche in Google Scholar

2. World Health Organization. A global brief on hypertension: silent killer. Geneva: Global Health Crises; 2013.Suche in Google Scholar

3. Lim, SS, Vos, T, Flaxman, AD, Danaei, G, Shibuya, K, Adair-Rohani, H, et al.. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:2224–60. https://doi.org/10.1016/S0140-6736(12)61766-8.Suche in Google Scholar

4. James, PA, Oparil, S, Carter, BL, Cushman, WC, Dennison-Himmelfarb, C, Handler, J, et al.. 2014 Evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 2014;311:507–20. https://doi.org/10.1001/jama.2013.284427.Suche in Google Scholar

5. Lewington, S, Clarke, R, Qizilbash, N, Collins, R, Peto, R. Age-specific relevance of blood pressure to vascular disease in one million people in 61 cohort studies. Prospective Studies Collaboration. Lancet 2002;360:1903–13.10.1016/S0140-6736(02)11911-8Suche in Google Scholar

6. World Health Organization. Global status report on noncommunicable diseases 2014. Switzerland; 2014.Suche in Google Scholar

7. Chockalingam, A. World hypertension day and global awareness. Can J Cardiol 2008;24:441–4. https://doi.org/10.1016/s0828-282x(08)70617-2.Suche in Google Scholar

8. Law, MR, Morris, JK, Wald, NJ. Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ 2009;338:1245. https://doi.org/10.1136/bmj.b1665.Suche in Google Scholar

9. Magadula, J, Mbwambo, Z. Pharmacological activities of African Garcinia plants. First Edit. New York, USA: Open Science Publishers; 2014.Suche in Google Scholar

10. Lakshmi, T, Roy, A, Durgha, K, Manjusha, V. Coping with hypertension using safer herbal medicine - a therapeutic review. Int J Drug Dev Res 2011;3:31–57.Suche in Google Scholar

11. Iwu, MM. Antihepatoxic constituents of Garcinia kola seeds. Experientia 1985;41:699–700. https://doi.org/10.1007/bf02007729.Suche in Google Scholar

12. Farombi, E, Adewoye, E, Owoyele, B, Onasanwo, S. Analgesic and anti-inflammatory effects of Kolaviron (a Garcinia kola seed extract). Afr J Biomed Res 2000;3:171–4.Suche in Google Scholar

13. Farombi, EO, Tahnteng, JG, Agboola, AO, Nwankwo, JO, Emerole, GO. Chemoprevention of 2-acetylaminofluorene-induced hepatotoxicity and lipid peroxidation in rats by kolaviron - a Garcinia kola seed extract. Food Chem Toxicol 2000;38:535–41. https://doi.org/10.1016/s0278-6915(00)00039-9.Suche in Google Scholar

14. Adaramoye, OA, Farombi, EO, Adeyemi, EO, Emerole, GO. Comparative study on the antioxidant properties of flavonoids of Garcinia kola seeds. Pak J Med Sci 2005;21:331–9.Suche in Google Scholar

15. Farombi, EO, Akanni, OO, Emerole, GO. Antioxidant and scavenging activities of flavonoid extract (Kolaviron) of Garcinia kola seeds. Pharm Biol 2002;40:107–16. https://doi.org/10.1076/phbi.40.2.107.5838.Suche in Google Scholar

16. Iwu, MM, Igboko, OA, Okunji, CO, Tempesta, MS. Antidiabetic and aldose reductase activities of biflavanones of Garcinia kola. J Pharm Pharmacol 1990;42:290–2. https://doi.org/10.1111/j.2042-7158.1990.tb05412.x.Suche in Google Scholar PubMed

17. Adaramoye, OA, Adeyemi, EO. Hypoglycaemic and hypolipidaemic effects of fractions from kolaviron, a biflavonoid complex from Garcinia Kola in streptozotocin-induced diabetes mellitus rats. J Pharm Pharmacol 2006;58:121–8. https://doi.org/10.1211/jpp.58.1.0015.Suche in Google Scholar PubMed

18. National Academy of Sciences. Guide for the care and use of laboratory animals, 8th ed. Washington DC: National Academies Press; 2011.Suche in Google Scholar

19. Akindele, AJ, Iyamu, EA, Dutt, P, Satti, NK, Adeyemi, OO. Ameliorative effect of hydroethanolic leaf extract of Byrsocarpus coccineus in alcohol- and sucrose-induced hypertension in rats. J Tradit Complement Med 2014;4:177–88. https://doi.org/10.4103/2225-4110.129562.Suche in Google Scholar

20. Ayepola, OR, Chegou, NN, Brooks, NL, Oguntibeju, OO. Kolaviron, a Garcinia biflavonoid complex ameliorates hyperglycemia-mediated hepatic injury in rats via suppression of inflammatory responses. BMC Complement Altern Med 2013;13:363. 10.1186/1472-6882-13-363.10.1186/1472-6882-13-363Suche in Google Scholar

21. Jeffers, BW, Bhambri, R, Robbins, J. Uptitrating amlodipine significantly reduces blood pressure in diabetic patients with hypertension: a retrospective, pooled analysis. Vasc Health Risk Manag 2014;10:651–9. 10.2147%2FVHRM.S64511.10.2147/VHRM.S64511Suche in Google Scholar

22. Godfraind, T. Antioxidant effects and the therapeutic mode of action of calcium channel blockers in hypertension and atherosclerosis. Philos Trans R Soc B Biol Sci 2005;360:2259–72. https://doi.org/10.1098/rstb.2005.1774.Suche in Google Scholar

23. Patel, SS, Verma, NK, Ravi, V, Gauthaman, K, Soni, N. Antihypertensive effect of an aqueous extract of Passiflora nepalensis wall. Int J Appl Res Nat Prod 2010;3:22–7.Suche in Google Scholar

24. Rupp, H, Brilla, CG, Maisch, B. Hypertension and alcohol: central and peripheral mechanisms. Herz 1996;21:258–64.Suche in Google Scholar

25. Arkwright, PD, Beilin, LJ, Vandongen, R, Rouse, IA, Lalor, C. The pressor effect of moderate alcohol consumption in man: a search for mechanisms. Circulation 1982;66:515–9. https://doi.org/10.1161/01.cir.66.3.515.Suche in Google Scholar

26. Russ, R, Abdel-Rahman, ARA, Wooles, WR. Role of the sympathetic nervous system in ethanol-induced hypertension in rats. Alcohol 1991;8:301–7. https://doi.org/10.1016/0741-8329(91)90433-w.Suche in Google Scholar

27. Husain, K, Ansari, RA, Ferder, L. Alcohol-induced hypertension: mechanism and prevention. World J Cardiol 2014;6:245. https://doi.org/10.4330/wjc.v6.i5.245.Suche in Google Scholar PubMed PubMed Central

28. Bunag, RD, Tomita, T, Sasaki, S. Chronic sucrose ingestion induces mild hypertension and tachycardia in rats. Hypertension 1983;5:218–25. https://doi.org/10.1161/01.hyp.5.2.218.Suche in Google Scholar PubMed

29. Bilanda, DC, Dimo, T, Dzeufiet Djomeni, PD, Bella, NMT, Aboubakar, OBF, Nguelefack, TB, et al.. Antihypertensive and antioxidant effects of Allanblackia floribunda Oliv. (Clusiaceae) aqueous extract in alcohol- and sucrose-induced hypertensive rats. J Ethnopharmacol 2010;128:634–40. https://doi.org/10.1016/j.jep.2010.02.025.Suche in Google Scholar PubMed

30. Johnson, RJ, Segal, MS, Sautin, Y, Nakagawa, T, Feig, DI, Kang, DH, et al.. Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr 2007;86:899–906. https://doi.org/10.1093/ajcn/86.4.899.Suche in Google Scholar PubMed

31. Parik, T, Allikmets, K, Teesalu, R, Zilmer, M. Oxidative stress and hyperinsulinaemia in essential hypertension: different facets of increased risk. J Hypertens 1996;14:407–10. https://doi.org/10.1097/00004872-199603000-00019.Suche in Google Scholar PubMed

32. Vaziri, ND, Ni, Z, Oveisi, F, Trnavsky-Hobbs, DL. Effect of antioxidant therapy on blood pressure and NO synthase expression in hypertensive rats. Hypertension 2000;36:957–64. https://doi.org/10.1161/01.hyp.36.6.957.Suche in Google Scholar PubMed

33. Ahmad, KA, Yuan Yuan, D, Nawaz, W, Ze, H, Zhuo, CX, Talal, B, et al.. Antioxidant therapy for management of oxidative stress induced hypertension. Free Radic Res 2017;51:428–38. https://doi.org/10.1080/10715762.2017.1322205.Suche in Google Scholar PubMed

34. Mazzali, M, Hughes, J, Kim, YG, Jefferson, JA, Kang, DH, Gordon, KL, et al.. Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension 2001;38:1101–6. https://doi.org/10.1161/hy1101.092839.Suche in Google Scholar PubMed

35. Farombi, EO, Adepoju, BF, Ola-Davies, OE, Emerole, GO. Chemoprevention of aflatoxin B1-induced genotoxicity and hepatic oxidative damage in rats by kolaviron, a natural biflavonoid of Garcinia kola seeds. Eur J Cancer Prev 2005;14:207–14. https://doi.org/10.1097/00008469-200506000-00003.Suche in Google Scholar PubMed

36. Husain, K, Vazquez, M, Ansari, RA, Malafa, MP, Lalla, J. Chronic alcohol-induced oxidative endothelial injury relates to angiotensin II levels in the rat. Mol Cell Biochem 2008;307:51–8. https://doi.org/10.1007/s11010-007-9583-6.Suche in Google Scholar PubMed

37. Rodrigo, R, Prat, H, Passalacqua, W, Araya, J, Guichard, C, Bächler, JP. Relationship between oxidative stress and essential hypertension. Hypertens Res 2007;30:1159–67. https://doi.org/10.1291/hypres.30.1159.Suche in Google Scholar PubMed

38. Laursen, JB, Rajagopalan, S, Galis, Z, Tarpey, M, Freeman, BA, Harrison, DG. Role of superoxide in angiotensin II-induced but not catecholamine-induced hypertension. Circulation 1997;95:588–93. https://doi.org/10.1161/01.cir.95.3.588.Suche in Google Scholar PubMed

39. Bauersachs, J, Bouloumié, A, Fraccarollo, D, Hu, K, Busse, R, Ertl, G. Endothelial dysfunction in chronic myocardial infarction despite increased vascular endothelial nitric oxide synthase and soluble guanylate cyclase expression: role of enhanced vascular superoxide production. Circulation 1999;100:292–8. https://doi.org/10.1161/01.cir.100.3.292.Suche in Google Scholar PubMed

40. Somers, MJ, Mavromatis, K, Galis, ZS, Harrison, DG. Vascular superoxide production and vasomotor function in hypertension induced by deoxycorticosterone acetate-salt. Circulation 2000;101:1722–8. https://doi.org/10.1161/01.cir.101.14.1722.Suche in Google Scholar PubMed

41. Farombi, EO, Nwaokeafor, IA. Anti-oxidant mechanisms of kolaviron: studies on serum lipoprotein oxidation, metal chelation and oxidative membrane damage in rats. Clin Exp Pharmacol Physiol 2005;32:667–74. https://doi.org/10.1111/j.0305-1870.2005.04248.x.Suche in Google Scholar PubMed

42. Zeng, C, Villar, VAM, Yu, P, Zhou, L, Jose, PA. Reactive oxygen species and dopamine receptor function in essential hypertension. Clin Exp Hypertens 2009;31:156–78. https://doi.org/10.1080/10641960802621283.Suche in Google Scholar PubMed PubMed Central

43. Drummond, GR, Selemidis, S, Griendling, KK, Sobey, CG. Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets. Nat Rev Drug Discov 2011;10:453–71. https://doi.org/10.1038/nrd3403.Suche in Google Scholar PubMed PubMed Central

44. Al Disi, SS, Anwar, MA, Eid, AH. Anti-hypertensive herbs and their mechanisms of action: Part I. Front Pharmacol 2016;6:1–24. https://doi.org/10.3389/fphar.2015.00323.Suche in Google Scholar PubMed PubMed Central

45. Adaramoye, OA, Nwosu, IO, Farombi, EO. Sub-acute effect of N G-nitro-l-arginine methyl-ester (L-NAME) on biochemical indices ins rats: protective effects of Kolaviron and extract of Curcuma longa L. Pharmacognosy Res 2012;4:127–33. https://doi.org/10.4103/0974-8490.99071.Suche in Google Scholar PubMed PubMed Central

46. Uche, OK, Osakpolo, RFA. Kolaviron attenuates elevation in blood pressure and ameliorates dyslipidemia in salt-induced hypertensive Sprague-Dawley rats. Afr J Biomed Res 2018;21:219–24.Suche in Google Scholar

47. Castro, C, Lorenzo, AG, González, A, Cruzado, M. Garlic components inhibit angiotensin II-induced cell-cycle progression and migration: involvement of cell-cycle inhibitor p27Kip1 and mitogen-activated protein kinase. Mol Nutr Food Res 2010;54:781–7. https://doi.org/10.1002/mnfr.200900108.Suche in Google Scholar PubMed

48. Oyagbemi, AA, Omobowale, TO, Adedapo, AA, Yakubu, MA. Kolaviron, biflavonoid complex from the seed of Garcinia kola attenuated angiotensin II- and lypopolysaccharide-induced vascular smooth muscle cell proliferation and nitric oxide production. Pharmacognosy Res 2016;8:S50–5. https://doi.org/10.4103/0974-8490.178647.Suche in Google Scholar PubMed PubMed Central

Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/jcim-2020-0354).

Received: 2020-09-14
Accepted: 2021-01-08
Published Online: 2021-05-11

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Research Articles
  3. Comparative HPTLC fingerprinting profile and GC-MS analysis of raw and purified Guggulu (Commiphora wightii. Arn. Bhand) by Ayurvedic purification method
  4. Acute and subacute toxicity assessment of Madhulai Manappagu (Siddha herbal syrup formulation) in animal model
  5. Ethyl acetate fraction of Spathodea campanulata (Bignoniaceae) attenuates lead acetate induced testicular toxicity in male Wistar rats
  6. Comparative evaluation of cardioprotective activity of Gala and Fuji apple juice against isoprenaline-induced cardiotoxicity in rats
  7. Ameliorative effect of Kolaviron, an extract of Garcinia kola seeds, on induced hypertension
  8. Review Articles
  9. Herbal foodstuffs in Avicenna’s recommended diet to improve sperm quality and increase male fertility; an evidence-based approach
  10. Transmission modes of COVID-19 disease pandemic in the light of ancient wisdom of Ayurveda medicine: a review
  11. Burning mouth syndrome: a review of therapeutic approach
  12. Research Articles
  13. Identification of common features within massage therapists’ professional identity
  14. Psychometric validation of the modified Naranjo algorithm used in homeopathy for chronic cases
  15. An overview of the comparison of inhalation aromatherapy on emotional distress of female and male patients in preoperative period
  16. Comparing the effectiveness of mother’s live lullaby and recorded lullaby on physiological responses and sleep of preterm infants: a clinical trial study
  17. The effect of hypnotherapy on exam anxiety among nursing students
  18. The effect of abdominal massage (I Love You method) on the gastric function of preterm infants hospitalized in the neonatal intensive care units: a randomized clinical trial
  19. Effect of Arjun Chāl on cardiovascular risk factors – a randomized controlled clinical trial
  20. Case Report
  21. Ayurvedic management of female infertility due to tubal blockage
https://doi.org/10.1515/jcim-2020-0354
Schlagwörter für diesen Artikel
antihypertensive; antioxidant; cardiovascular diseases; Garcinia kola; hypertension; Kolaviron

Artikel in diesem Heft

  1. Frontmatter
  2. Research Articles
  3. Comparative HPTLC fingerprinting profile and GC-MS analysis of raw and purified Guggulu (Commiphora wightii. Arn. Bhand) by Ayurvedic purification method
  4. Acute and subacute toxicity assessment of Madhulai Manappagu (Siddha herbal syrup formulation) in animal model
  5. Ethyl acetate fraction of Spathodea campanulata (Bignoniaceae) attenuates lead acetate induced testicular toxicity in male Wistar rats
  6. Comparative evaluation of cardioprotective activity of Gala and Fuji apple juice against isoprenaline-induced cardiotoxicity in rats
  7. Ameliorative effect of Kolaviron, an extract of Garcinia kola seeds, on induced hypertension
  8. Review Articles
  9. Herbal foodstuffs in Avicenna’s recommended diet to improve sperm quality and increase male fertility; an evidence-based approach
  10. Transmission modes of COVID-19 disease pandemic in the light of ancient wisdom of Ayurveda medicine: a review
  11. Burning mouth syndrome: a review of therapeutic approach
  12. Research Articles
  13. Identification of common features within massage therapists’ professional identity
  14. Psychometric validation of the modified Naranjo algorithm used in homeopathy for chronic cases
  15. An overview of the comparison of inhalation aromatherapy on emotional distress of female and male patients in preoperative period
  16. Comparing the effectiveness of mother’s live lullaby and recorded lullaby on physiological responses and sleep of preterm infants: a clinical trial study
  17. The effect of hypnotherapy on exam anxiety among nursing students
  18. The effect of abdominal massage (I Love You method) on the gastric function of preterm infants hospitalized in the neonatal intensive care units: a randomized clinical trial
  19. Effect of Arjun Chāl on cardiovascular risk factors – a randomized controlled clinical trial
  20. Case Report
  21. Ayurvedic management of female infertility due to tubal blockage
Jetzt anmelden und 20% sparen
Institutioneller Zugang
Wie funktioniert Authentifizierung?
Haben Sie eine Idee, wie wir unsere Website verbessern können?
Bitte schreiben Sie uns.
© 2025 De Gruyter Brill
Heruntergeladen am 8.9.2025 von https://www.degruyterbrill.com/document/doi/10.1515/jcim-2020-0354/pdf
Button zum nach oben scrollen