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Importance of moderate-to-vigorous physical activity during the COVID-19 pandemic: a systematic review and meta-analysis

  • Purwo Sri Rejeki EMAIL logo , Bendix Samarta Witarto , Andro Pramana Witarto , Salsabila Nabilah Rifdah , Ifan Ali Wafa , Dita Mega Utami , Nabilah Izzatunnisa , Citrawati Dyah Kencono Wungu , Siti Khaerunnisa , Sakina und Nur Ezza Fazleen Mohd Fathil
Veröffentlicht/Copyright: 24. März 2023
Journal of Basic and Clinical Physiology and Pharmacology
Aus der Zeitschrift Journal of Basic and Clinical Physiology and Pharmacology Band 34 Heft 3

Abstract

Moderate-to-vigorous physical activity (MVPA) has been shown to have a favorable effect on many diseases as a complementary therapy and is a critical component of healthy living. During the pandemic era, physical activity has been promoted for resistance against coronavirus disease 2019 (COVID-19). However, there is scarce evidence on whether MVPA could reduce the infectivity and susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The objective of this meta-analysis was to determine the effect of MVPA on morbidity, mortality, and duration of hospitalization in COVID-19 patients. We performed a comprehensive search of five online databases for eligible studies up to September 9, 2021. Meta-analyses were conducted to determine the association between MVPA and COVID-19-related morbidity, hospitalization, and mortality. The odds ratio (OR) was applied as the summary statistic for the primary outcomes. Secondary analyses were conducted to evaluate the difference in the metabolic equivalent of tasks (METs) between the outcome and non-outcome groups with the mean difference as the pooled effect. This meta-analysis included eight observational studies. We found that MVPA significantly reduced the odds of contracting SARS-CoV-2 infection (OR=0.88; 95% confidence interval [CI] = 0.85–0.92), hospitalization (OR=0.56; 95% CI=0.35–0.92), and mortality (OR=0.42; 95% CI=0.21–0.81) due to COVID-19 compared to no physical activity. METs≥500 min/week were linked to decreased morbidity and mortality of COVID-19 (OR=0.94 [95% CI=0.90–0.98]; OR=0.56 [95% CI=0.38–0.83]). COVID-19 patients with MVPA demonstrated a lower risk of COVID-19-related morbidity, hospitalization, and mortality compared to those who were less active, highlighting the importance of an active lifestyle despite the pandemic situation where such activities are limited.

Keywords: active lifestyle; COVID-19; hospitalization; morbidity; mortality
Corresponding author: Purwo Sri Rejeki Department of Medical Physiology and Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java 60131, Indonesia, Phone: +62 8214 1559 388, E-mail:

Funding source: Universitas Airlangga

Award Identifier / Grant number: 830/UN3.15/PT/2021

Acknowledgments

We would like to express our gratitude to the Faculty of Medicine, Universitas Airlangga for providing good facilities for making the project a success.

  1. Research funding: This research was supported by grants from the LPPM mandate of Airlangga University (830/UN3.15/PT/2021).

  2. Author contributions: PSR, BSW, APW, DMU, and NI structured the study, participated in its design, conducted a literature search, data extraction, analysis, and interpretation, and was involved in the writing of the manuscript; SK, SH and NEFMF participated in data extraction and quality assessment; SNR and IAW structured the research and participated in its design; CDKW conducts a technical assessment. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Conflicts of interests: The authors have declared that no competing interests exist.

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Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/jbcpp-2023-0040).

Received: 2023-02-08
Accepted: 2023-03-02
Published Online: 2023-03-24

© 2023 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jbcpp-2023-0040
Schlagwörter für diesen Artikel
active lifestyle; COVID-19; hospitalization; morbidity; mortality

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Investigating periprostatic adipose tissue as a driving force of prostate cancer progression: a new source of information for the advancement of targeted therapy in metastatic prostate cancer
  4. Reviews
  5. Pathophysiological effects of cadmium(II) on human health-a critical review
  6. The role of synbiotics in improving inflammatory status in nasopharyngeal carcinoma patients
  7. Anti-ageing effects of FDA-approved medicines: a focused review
  8. Diagnosis and management of uterine fibroids: current trends and future strategies
  9. Importance of moderate-to-vigorous physical activity during the COVID-19 pandemic: a systematic review and meta-analysis
  10. Original Articles
  11. Healthcare workers’ knowledge of evidence-based guidelines for prevention of ventilator-associated pneumonia in Hodeida, Yemen
  12. Comparison of cardiac autonomic function across complete glycaemic spectrum
  13. Prognostic value of heart rate variability in acute coronary syndrome
  14. Insights into the protective capacity of human dental pulp stem cells and its secretome in cisplatin-induced nephrotoxicity: effects on oxidative stress and histological changes
  15. Caffeine impairs anticonvulsant effects of levetiracetam in the maximal electroshock seizure threshold test in mice
  16. Antioxidant activity in off and on-pump coronary artery bypass grafting and valve replacement surgery
  17. A drug utilisation pattern in non-dialysis patients of diabetic nephropathy in a government-run tertiary care hospital in South-Asia
  18. Inguinal lymphadenectomy in penile cancer patients: a comparison between open and video endoscopic approach in a multicenter setting
  19. A randomized controlled trial to evaluate the efficacy of electrical vestibular nerve stimulation (VeNS), compared to a sham control for the management of sleep in young adults
  20. Short Communication
  21. The role of Bruton’s kinase inhibitors (BTKi) in accelerated Chronic Lymphocytic Leukemia (a-CLL): a case of successful response to acalabrutinib
  22. Letter to the Editor
  23. A hypothesis that Notopterol may be effective in COVID-19 via JAK/STAT and other signaling pathways
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