Antioxidant activity in off and on-pump coronary artery bypass grafting and valve replacement surgery

Ali Azari; Vafa Baradaran Rahimi; Zahra Moravvej; Amir Ali Rahsepar; Majid Ghayour-Mobarhan; Maryam Salehi; Leila Bigdelu

doi:10.1515/jbcpp-2022-0244

Article

Antioxidant activity in off and on-pump coronary artery bypass grafting and valve replacement surgery

Ali Azari , Vafa Baradaran Rahimi , Zahra Moravvej , Amir Ali Rahsepar , Majid Ghayour-Mobarhan , Maryam Salehi and Leila Bigdelu

Published/Copyright: February 20, 2023

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From the journal Journal of Basic and Clinical Physiology and Pharmacology Volume 34 Issue 3

Abstract

Objectives

Cardiac surgeries initiate oxidative stress, increasing organ dysfunction development and mortality. The present study investigated the superoxide dismutase (SOD) activity, as an antioxidant enzyme, in patients undergoing coronary artery bypass (CABG) and heart valve replacement surgeries.

Methods

A prospective study was performed on patients with proven coronary artery disease (CAD) or valvular heart disease (VHD) candidates for on- or off-pump CABG and valve replacement surgery. Serum SOD activity was measured preoperatively, at 24 h postoperatively, and at the time of discharge. In addition, echocardiography was performed before surgery and at discharge.

Results

A total of 48, 51, and 47 patients were enrolled in the on-pump, off-pump CABG, and valve replacement groups, respectively. Baseline serum SOD activity showed no significant association with BMI, age, and blood pressure in either CAD or VHD patients. The SOD values decreased at the 24 h postoperative time and then increased at the time of discharge in all groups, except for a slight decrease in the on-pump group. The changes in serum SOD values were not significantly different for the three surgical groups.

Conclusions

The serum SOD activities fell significantly after CABG and valve replacement surgery. Further investigation is emphasized for the role of SOD in oxidative stress after cardiac surgery.

Keywords: antioxidant; coronary artery disease; oxidative stress; superoxide dismutase; valvular heart disease

Corresponding author: Leila Bigdelu, MD, Fellowship of Echocardiography, Associate Professor, Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; and Department of Cardiovascular Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Azadi Sq., Vakil Abad Highway, Mashhad, 9177948564, Iran, E-mail: cardiacclinicdrab@gmail.com

Funding source: 920908

Funding source: Mashhad University of Medical Sciences

Award Identifier / Grant number: Unassigned

Research funding: This study was financially supported by grant Number: 920908 from Mashhad University of Medical Sciences.
Author contributions: Ali Azari: Conceptualisation, Methodology, Investigation; Vafa Baradaran Rahimi: Writing – Original Draft, Writing – review & editing, Formal Analysis; Zahra Moravvej: Investigation, Data Curation; Amir Ali Rahsepar: Methodology, Investigation; Majid Ghayour-Mobarhan: Methodology, Investigation; Maryam Salehi: Formal Analysis, Data Curation; Leila Bigdelu: Conceptualisation, Methodology, Funding Acquisition, Investigation, Supervision.
Competing interests: The authors declare no conflict of interest.
Informed consent: All patients received and signed the written informed consent.
Ethical approval: The study protocol was confirmed by the ethics committee of Mashhad University of Medical Sciences, Mashhad, Iran.

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Received: 2022-09-07

Accepted: 2023-01-23

Published Online: 2023-02-20

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Articles in the same Issue

https://doi.org/10.1515/jbcpp-2022-0244

Keywords for this article

antioxidant; coronary artery disease; oxidative stress; superoxide dismutase; valvular heart disease