Glucose absorption in the intestine of albino rats
-
Olalubi A. Oluwasogo
,
Owoyele B. Victor
Abstract
Background: The ability to absorb substances from the external environment is one of the features that make animals different from inanimate objects. In mammalian species, this quality is mainly the role of the small intestine. The process of absorption mainly takes place in the small intestine. This study was carried out to investigate the rate of glucose absorption in the intestine of albino rats and the effect of calcium and ouabain on the rate of glucose absorption.
Methods: Albino rats weighing between 200 and 250 g were used for this experiment. Guts were isolated and cut to segments. Test solution was injected into each of the isolated segments, which were then assayed for glucose.
Results: The result revealed that the rate of glucose absorption in the intestine of albino rats were found to be 3.02×10−1 g/min at the mucosa-to-serosa surface and 3.00×10−1 g/min at the serosa-to-mucosa surface, indicating that glucose was absorbed at both surfaces and that the rate of glucose absorption was higher in the mucosa-to-serosa direction than in the opposite direction. The rate of intestinal glucose absorption at different regions of the intestine and the effect of varying concentrations of calcium on the rate of glucose absorption revealed that glucose absorption was highest at the duodenum and lowest at the ileum.
Conclusions: Ouabain blocked the rate of absorption of glucose in the intestine of albino rats.
Acknowledgments
The authors wish to thank I. O. Akhiromen of the Zoology Department, University of Ilorin, Ilorin, Nigeria, for his technical support.
Author contributions: O.A.O. designed and performed the experiments and supervised and submitted the manuscript. O.B.V. collected and analyzed the data and prepared the manuscript. A.M.T. analyzed the data and assisted in preparing the manuscript. A.J.K. interpreted the data, restructured the concept, and edited and revised the manuscript. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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Artikel in diesem Heft
- Frontmatter
- Reviews
- Assessment of paediatric pain: a critical review
- Can genotype determine the sports phenotype? A paradigm shift in sports medicine
- Oxidative Stress
- Neuroprotective effect of Decalepis hamiltonii on cyclophosphamide-induced oxidative stress in the mouse brain
- Hydroxycitric acid ameliorates high-fructose-induced redox imbalance and activation of stress sensitive kinases in male Wistar rats
- Metabolism
- Glucose absorption in the intestine of albino rats
- Inflammation
- Antinociceptive and anti-inflammatory potentials of kolaviron: mechanisms of action
- Efficacy of oral vs. intratympanic corticosteroids in sudden sensorineural hearing loss
- Evaluation of antinociceptive and anti-inflammatory properties of methanolic crude extract of Lophopetalum javanicum (bark)
- Anti-nociceptive and anti-inflammatory effects of Withania somnifera root in fructose fed male rats
- Phytotherapy
- Biflavonoid fraction from Garcinia kola seed ameliorates hormonal imbalance and testicular oxidative damage by anti-tuberculosis drugs in Wistar rats
- Protective effect of Scutellaria species on AAPH-induced oxidative damage in human erythrocyte
- Miscellaneous
- Role of monocyte chemoattractant protein-1, stromal derived factor-1 and retinoic acid in pathophysiology of neuropathic pain in rats
- Hormonal and organ-specific dysfunction induced by the interaction between titanium dioxide nanoparticles and salicylic acid in male mice
- Case Report
- Blood pressure variability and baroreflex sensitivity of a healthy male during cold pressor test that induced development of neurocardiogenic syncope
