Cerebral stroke injury: the role of cytokines and brain inflammation

References

1. Lo EH, Dalkara T, Moskowitz MA. Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci 2003;4: 399–415.10.1038/nrn1106Suche in Google Scholar

2. Norrving B, Kissela B. The global burden of stroke and need for a continuum of care. Neurology 2013;80:S5–12.10.1212/WNL.0b013e3182762397Suche in Google Scholar

3. Donnan GA, Fisher M, Macleod M, Davis SM. Stroke. Lancet 2008;371:1612–23.10.1016/S0140-6736(08)60694-7Suche in Google Scholar

4. Lakhan SE, Kirchgessner A, Hofer M. Inflammatory mechanisms in ischemic stroke: therapeutic approaches. J Transl Med 2009;7:97.10.1186/1479-5876-7-97Suche in Google Scholar

5. Muir KW, Tyrrell P, Sattar N, Warburton E. Inflammation and ischaemic stroke. Curr Opin Neurol 2007;20:334–42.10.1097/WCO.0b013e32813ba151Suche in Google Scholar

6. Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 1999;22:391–7.10.1016/S0166-2236(99)01401-0Suche in Google Scholar

7. Chamorro A, Hallenbeck J. The harms and benefits of inflammatory and immune responses in vascular disease. Stroke 2006;37:291–3.10.1161/01.STR.0000200561.69611.f8Suche in Google Scholar PubMed PubMed Central

8. Iadecola C, Anrather J. The immunology of stroke: from mechanisms to translation. Nat Med 2011;17:796–808.10.1038/nm.2399Suche in Google Scholar PubMed PubMed Central

9. Moskowitz MA, Lo EH, Iadecola C. The science of stroke: mechanisms in search of treatments. Neuron 2010;67:181–98.10.1016/j.neuron.2010.07.002Suche in Google Scholar PubMed PubMed Central

10. Allan SM, Rothwell NJ. Cytokines and acute neurodegeneration. Nat Rev Neurosci 2001;2:734–44.10.1038/35094583Suche in Google Scholar PubMed

11. Urra X, Cerveraa A, Villamor N, Planas AM, Chamorro A. Harms and benefits of lymphocyte subpopulations in patients with acute stroke. Neuroscience 2009;158:1174–83.10.1016/j.neuroscience.2008.06.014Suche in Google Scholar

12. Steinman L. A brief history of T_H17, the first major revision in the T_H1/T_H2 hypothesis of T cell-mediated tissue damage. Nat Med 2007;13:139–45.10.1038/nm1551Suche in Google Scholar

13. Gallelli L, Busceti MT, Vatrella A, Maselli R, Pelaia G. Update on anticytokine treatment for asthma. Biomed Res Int 2013;2013:104315.10.1155/2013/104315Suche in Google Scholar

14. Rubio-Perez JM, Morillas-Ruiz JM. A review: inflammatory process in Alzheimer’s disease, role of cytokines. Sci World J 2012;2012:756357.10.1100/2012/756357Suche in Google Scholar

15. Rock KL, Latz E, Ontiveros F, Kono H. The sterile inflammatory response. Annu Rev Immunol 2010;28:321–42.10.1146/annurev-immunol-030409-101311Suche in Google Scholar

16. Zhu Y, Yang GY, Ahlemeyer B, Pang L, Che XM, Culmsee C, et al. Transforming growth factor-β 1 increases bad phosphorylation and protects neurons against damage. J Neurosci 2002;22:3898–909.10.1523/JNEUROSCI.22-10-03898.2002Suche in Google Scholar

17. Spera PA, Ellison JA, Feuerstein GZ, Barone FC. IL-10 reduces rat brain injury following focal stroke. Neurosci Lett 1998;251: 189–92.10.1016/S0304-3940(98)00537-0Suche in Google Scholar

18. Banwell V, Sena ES, Macleod MR. Systematic review and stratified meta-analysis of the efficacy of interleukin-1 receptor antagonist in animal models of stroke. J Stroke Cerebrovasc Dis 2009;18:269–76.10.1016/j.jstrokecerebrovasdis.2008.11.009Suche in Google Scholar PubMed

19. Elkind MS. Impact of innate inflammation in population studies. Ann NY Acad Sci 2010;1207:97–106.10.1111/j.1749-6632.2010.05736.xSuche in Google Scholar PubMed

20. Offner H, Subramanian S, Parker SM, Afentoulis ME, Vandenbark AA, Hurn PD. Experimental stroke induces massive, rapid activation of the peripheral immune system. J Cereb Blood Flow Metab 2006;26:654–65.10.1038/sj.jcbfm.9600217Suche in Google Scholar PubMed

21. Lambertsen KL, Biber K, Finsen B. Inflammatory cytokines in experimental and human stroke. J Cereb Blood Flow Metab 2012;32:1677–98.10.1038/jcbfm.2012.88Suche in Google Scholar PubMed PubMed Central

22. Murray KN, Buggey HF, Denes A, Allan SM. Systemic immune activation shapes stroke outcome. Mol Cell Neurosci 2013;53:14–25.10.1016/j.mcn.2012.09.004Suche in Google Scholar PubMed

23. Mazzotta G, Sarchielli P, Caso V, Paciaroni M, Floridi A, Gallai V. Different cytokine levels in thrombolysis patients as predictors for clinical outcome. Eur J Neurol 2004;11:377–81.10.1111/j.1468-1331.2004.00798.xSuche in Google Scholar PubMed

24. Yan J, Greer JM, McCombe PA. Prolonged elevation of cytokine levels after human acute ischaemic stroke with evidence of individual variability. J Neuroimmunol 2012;246:78–84.10.1016/j.jneuroim.2012.02.013Suche in Google Scholar PubMed

25. Zeng L, Wang Y, Liu J, Wang L, Weng S, Chen K, et al. Pro-inflammatory cytokine network in peripheral inflammation response to cerebral ischemia. Neurosci Lett 2013;548:4–9.10.1016/j.neulet.2013.04.037Suche in Google Scholar PubMed

26. Tobinick E, Kim NM, Reyzin G, Rodriguez-Romanacce H, DePuy V. Selective TNF inhibition for chronic stroke and traumatic brain injury: an observational study involving 629 consecutive patients treated with perispinal etanercept. CNS Drugs 2012;26:1051–70.10.1007/s40263-012-0013-2Suche in Google Scholar PubMed

27. Caso JR, Moro MA, Lorenzo P, Lizasoain I, Leza JC. Involvement of IL-1β in acute stress-induced worsening of cerebral ischaemia in rats. Eur Neuropsychopharm 2007;17:600–7.10.1016/j.euroneuro.2007.02.009Suche in Google Scholar PubMed

28. Boutin H, LeFeuvre RA, Horai R, Asano M, Iwakura Y, Rothwell NJ. Role of IL-1α and IL-1β in ischemic brain damage. J Neurosci 2001;21:5528–34.10.1523/JNEUROSCI.21-15-05528.2001Suche in Google Scholar

29. Deroide N, Li X, Lerouet D, Van Vre E, Baker L, Harrison J, et al. MFGE8 inhibits inflammasome-induced IL-1β production and limits postischemic cerebral injury. J Clin Invest 2013;123: 1176–81.10.1172/JCI65167Suche in Google Scholar PubMed PubMed Central

30. Clark WM, Rinker LG, Lessov NS, Hazel K, Eckenstein F. Time course of IL-6 expression in experimental CNS ischemia. Neurol Res 1999;21:287–92.10.1080/01616412.1999.11740933Suche in Google Scholar PubMed

31. Acalovschi D, Wiest T, Hartmann M, Farahmi M, Mansmann U, Auffarth GU, et al. Multiple levels of regulation of the interleukin-6 system in stroke. Stroke 2003;34:1864–9.10.1161/01.STR.0000079815.38626.44Suche in Google Scholar PubMed

32. Vila N, Castillo J, Davalos A, Chamorro A. Proinflammatory cytokines and early neurological worsening in ischemic stroke. Stroke 2000;31:2325–9.10.1161/01.STR.31.10.2325Suche in Google Scholar

33. Clark WM, Rinker LG, Lessov NS, Hazel K, Hill JK, Stenzel-Poore M, et al. Lack of interleukin-6 expression is not protective against focal central nervous system ischemia. Stroke 2000;31:1715–20.10.1161/01.STR.31.7.1715Suche in Google Scholar PubMed

34. Chen WY, Chang MS. IL-20 is regulated by hypoxia-inducible factor and up-regulated after experimental ischemic stroke. J Immunol 2009;182:5003–12.10.4049/jimmunol.0803653Suche in Google Scholar PubMed

35. Smith CJ, Emsley HC, Udeh CT, Vail A, Hoadley ME, Rothwell NJ, et al. Interleukin-1 receptor antagonist reverses stroke-associated peripheral immune suppression. Cytokine 2012;58:384–9.10.1016/j.cyto.2012.02.016Suche in Google Scholar PubMed

36. Gueorguieva I, Clark SR, McMahon CJ, Scarth S, Rothwell NJ, Tyrell PJ, et al. Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage. Br J Clin Pharmacol 2008;65:317–25.10.1111/j.1365-2125.2007.03026.xSuche in Google Scholar PubMed PubMed Central

37. Bodhankar S, Chen Y, Vandenbark AA, Murphy SJ, Offner H. IL-10-producing B-cells limit CNS inflammation and infarct volume in experimental stroke. Metab Brain Dis 2013;28:375–86.10.1007/s11011-013-9413-3Suche in Google Scholar PubMed PubMed Central

38. Tarkowski E, Rosengren L, Blomstrand C, Wikkelso C, Jensen C, Ekholm S, et al. Intrathecal release of pro- and anti-inflammatory cytokines during stroke. Clin Exp Immunol 1997;110:492–9.10.1046/j.1365-2249.1997.4621483.xSuche in Google Scholar PubMed PubMed Central

39. da Cunha AA, Ferreira AG, Loureiro SO, da Cunha MJ, Schmitz F, Netto CA, et al. Chronic hyperhomocysteinemia increases inflammatory markers in hippocampus and serum of rats. Neurochem Res 2012;37:1660–9.10.1007/s11064-012-0769-2Suche in Google Scholar PubMed

40. Siniscalchi A. Hyperhomocysteinemia in neurologic diseases. Recenti Prog Med 2004;95:371–5; quiz 402.Suche in Google Scholar

41. Siniscalchi A, De Sarro G, Loizzo S, Gallelli L. High plasma homocysteine and low serum folate levels induced by antiepileptic drugs in Down Syndrome. J Dev Disabil 2012;18:70–6.Suche in Google Scholar

42. Siniscalchi A, Gallelli L, Mercuri NB, Ibbadu GF, De Sarro G. Role of lifestyle factors on plasma homocysteine levels in Parkison’s disease patients treated with levodopa. Nutr Neurosci 2006;9:11–6.10.1080/10284150600583446Suche in Google Scholar PubMed

43. Siniscalchi A, Mancuso F, Gallelli L, Ibbadu GF, Mercuri NB, De Sarro G. Increase in plasma homocysteine levels induced by drug treatments in neurologic patients. Pharmacol Res 2005;52:367–75.10.1016/j.phrs.2005.05.013Suche in Google Scholar PubMed

44. Sprague AH, Khalil RA. Inflammatory cytokines in vascular dysfunction and vascular disease. Biochem Pharmacol 2009;78:539–52.10.1016/j.bcp.2009.04.029Suche in Google Scholar PubMed PubMed Central

45. Iversen PO, Nicolaysen A, Kvernebo K, Benestad HB, Nicolaysen G. Human cytokines modulate arterial vascular tone via endothelial receptors. Pflugers Arch 1999;439:93–100.10.1007/s004240051132Suche in Google Scholar

46. Vila E, Salaices M. Cytokines and vascular reactivity in resistance arteries. Am J Physiol Heart Circ Physiol 2005;288:H1016–21.10.1152/ajpheart.00779.2004Suche in Google Scholar PubMed

47. Hallenbeck JM. The many faces of tumor necrosis factor in stroke. Nat Med 2002;8:1363–8.10.1038/nm1202-1363Suche in Google Scholar PubMed

48. Song W, Huo T, Guo F, Wang H, Wei H, Yang Q, et al. Globular adiponectin elicits neuroprotection by inhibiting NADPH oxidase-mediated oxidative damage in ischemic stroke. Neuroscience 2013;248C:136–44.10.1016/j.neuroscience.2013.05.063Suche in Google Scholar PubMed

49. Pham LD, Hayakawa K, Seo JH, Nguyen MN, Som AT, Lee BJ, et al. Crosstalk between oligodendrocytes and cerebral endothelium contributes to vascular remodeling after white matter injury. Glia 2012;60:875–81.10.1002/glia.22320Suche in Google Scholar PubMed PubMed Central

50. de Franciscis S, Mastroroberto P, Gallelli L, Buffone G, Montemurro R, Serra R. Increased plasma levels of metalloproteinase-9 and neutrophil gelatinase-associated lipocalin in a rare case of multiple artery aneurysm. Ann Vasc Surg 2013;27:1185 e5–7.10.1016/j.avsg.2013.01.011Suche in Google Scholar PubMed

51. de Franciscis S, Gallelli L, Battaglia L, Molinari V, Montemurro R, Stillitano DM, et al. Cilostazol prevents foot ulcers in diabetic patients with peripheral vascular disease. Int Wound J 2013; Epub ahead of print 15 May 2013. DOI: 10.1111/iwj.12085.10.1111/iwj.12085Suche in Google Scholar PubMed PubMed Central

52. Serra R, Buffone G, Falcone D, Molinari V, Scaramuzzino M, Gallelli L, et al. Chronic venous leg ulcers are associated with high levels of metalloproteinases-9 and neutrophil gelatinase-associated lipocalin. Wound Repair Regen 2013;21:395–401.10.1111/wrr.12035Suche in Google Scholar PubMed

53. Serra R, Gallelli L, Buffone G, Molinari V, Stillitano DM, Palmieri C, et al. Doxycycline speeds up healing of chronic venous ulcers. Int Wound J 2013; Epub ahead of print 5 Apr 2013. DOI: 10.1111/iwj.12077.10.1111/iwj.12077Suche in Google Scholar PubMed PubMed Central

54. Liu H, Wei X, Chen L, Liu X, Li S, Zhang X. Tetramethylpyrazine analogue CXC195 protects against cerebral ischemia/reperfusion injury in the rat by an antioxidant action via inhibition of NADPH oxidase and iNOS expression. Pharmacology 2013;92:198–206.10.1159/000354722Suche in Google Scholar PubMed

55. Offner H, Vandenbark AA, Hurn PD. Effect of experimental stroke on peripheral immunity: CNS ischemia induces profound immunosuppression. Neuroscience 2009;158:1098–111.10.1016/j.neuroscience.2008.05.033Suche in Google Scholar PubMed PubMed Central

56. Chapman KZ, Dale VQ, Denes A, Bennett G, Rothwell NJ, Allan SM, et al. A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke. J Cereb Blood Flow Metab 2009;29:1764–8.10.1038/jcbfm.2009.113Suche in Google Scholar PubMed

57. Chang L, Chen Y, Li J, Liu Z, Wang Z, Chen J, et al. Cocaine- and amphetamine-regulated transcript modulates peripheral immunity and protects against brain injury in experimental stroke. Brain Behav Immun 2011;25:260–9.10.1016/j.bbi.2010.09.017Suche in Google Scholar PubMed

58. Kamel H, Iadecola C. Brain-immune interactions and ischemic stroke: clinical implications. Arch Neurol 2012;69:576–81.10.1001/archneurol.2011.3590Suche in Google Scholar PubMed PubMed Central

59. Sanchez-Mendoza E, Bellver V, Merino JJ, Gonzalez M, Martinez-Murillo R, Oset-Gasque MJ. Review: could neurotransmitters influence neurogenesis and neurorepair after stroke? Neuropathol Appl Neurobiol 2013; Epub ahead of print 14 Aug 2013. DOI: 10.1111/nan.12082.10.1111/nan.12082Suche in Google Scholar PubMed

60. Albers GW, Goldstein LB, Hess DC, Wechsler LR, Furie KL, Gorelick PB, et al. Stroke Treatment Academic Industry Roundtable (STAIR) recommendations for maximizing the use of intravenous thrombolytics and expanding treatment options with intra-arterial and neuroprotective therapies. Stroke 2011;42:2645–50.10.1161/STROKEAHA.111.618850Suche in Google Scholar PubMed

61. Tiebosch IA, Crielaard BJ, Bouts MJ, Zwartbol R, Salas-Perdomo A, Lammers T, et al. Combined treatment with recombinant tissue plasminogen activator and dexamethasone phosphate-containing liposomes improves neurological outcome and restricts lesion progression after embolic stroke in rats. J Neurochem 2012;123:65–74.10.1111/j.1471-4159.2012.07945.xSuche in Google Scholar PubMed

62. Rodriguez-Yanez M, Castellanos M, Sobrino T, Brea D, Ramos-Cabrer P, Pedraza S, et al. Interleukin-10 facilitates the selection of patients for systemic thrombolysis. BMC Neurol 2013;13:62.10.1186/1471-2377-13-62Suche in Google Scholar PubMed PubMed Central