Augmented primary humoral immune response and decreased cell-mediated immunity by Murraya koenigii in rats
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Inderjit Kaur
und
Swapan K. Bhattacharya
Abstract
Background:Murraya koenigii (Rutaceae) (curry patta: Hindi) of the family Rutaceae is used in the traditional Indian system of medicine for its immunomodulatory properties. The essential oil of the leaves of M. koenigii possesses antimicrobial, antifungal, and pesticidal activities and is used for the treatment of amebiasis, diabetes, and hepatitis. The present study was performed to evaluate the effect of M. koenigii on humoral and cell-mediated immune responses in rats.
Methods: Aqueous extract of M. koenigii leaves was administered orally in a dose of 350 mg/kg. Cell-mediated immunity was assessed by measuring foot pad thickness following sensitization by injection of keyhole limpet hemocyanin and subsequent challenge by the same. Humoral immunity was assessed by measurement of hemagglutination titer to sheep red blood cells (SRBCs).
Results: In the humoral immune response, the administration of M. koenigii [350 mg/kg per os (p.o.)] from day 1 to day 7 after sensitization with SRBC on day 0 caused a significant increase in the primary anti-SRBC titer. However, the secondary immune response was decreased significantly (p<0.05) as shown by a decrease in secondary anti-SRBC titer measured on day 11 following a booster dose of antigen on day 8. In the delayed-type hypersensitivity test, M. koenigii (350 mg/kg, p.o.), when administered for 14 days, produced a significant (p<0.05) decrease in foot pad thickness when compared with the control group.
Conclusions: Thus, these results suggest that oral administration of M. koenigii augments primary humoral immune response and decreases cell-mediated immunity.
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©2014 by Walter de Gruyter Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Review
- Cerebral stroke injury: the role of cytokines and brain inflammation
- Cardiovascular-Pulmonary Interactions
- Gene functional dynamics: environment as a trigger?
- Arrhythmogenesis after acute myocardial necrosis with and without preceding ischemia in rats
- Measuring cardiopulmonary parameters during dual-task while walking
- Calcium-dependent mechanisms mediate the vasorelaxant effects of Tridax procumbens (Lin) aqueous leaf extract in rat aortic ring
- Inflammation
- Effects of cyclosporine and phenytoin on biomarker expressions in gingival fibroblasts of children and adults: an in vitro study
- Anti-inflammatory and analgesic activities of the methanol leaf extract of Phyllanthus amarus in some laboratory animals
- Oxidative Stress
- Ameliorative effect of diallyl trisulphide on arsenic-induced oxidative stress in rat erythrocytes and DNA damage in lymphocytes
- Anticholinesterase and antioxidative properties of water-extractable phytochemicals from some citrus peels
- Immune Response
- Temporal expression of IL-1β and IL-10 in rat skin, muscle, small bowel, and colon wounds: a correlative study
- Augmented primary humoral immune response and decreased cell-mediated immunity by Murraya koenigii in rats
- Analgesic, anti-inflammatory, and heme biomineralization inhibitory properties of Entada africana ethanol leaf extract with antiplasmodial activity against Plasmodium falciparum
- Hematological Profile
- Hematological profile in neonatal jaundice
- Effects of blood lead level on biochemical and hematological parameters in children with neurological diseases of Western Maharashtra, India
- Phytotherapy
- Antipsychotic property of solvent-partitioned fractions of Lonchocarpus cyanescens leaf extract in mice
- Aphrodisiac effect of aqueous root extract of Lecaniodiscus cupanioides in sexually impaired rats
- Virgin coconut oil protects against liver damage in albino rats challenged with the anti-folate combination, trimethoprim-sulfamethoxazole
- Metabolism
- Evaluation of in vitro aldose reductase inhibitory potential of alkaloidal fractions of Piper nigrum, Murraya koenigii, Argemone mexicana, and Nelumbo nucifera
Artikel in diesem Heft
- Frontmatter
- Review
- Cerebral stroke injury: the role of cytokines and brain inflammation
- Cardiovascular-Pulmonary Interactions
- Gene functional dynamics: environment as a trigger?
- Arrhythmogenesis after acute myocardial necrosis with and without preceding ischemia in rats
- Measuring cardiopulmonary parameters during dual-task while walking
- Calcium-dependent mechanisms mediate the vasorelaxant effects of Tridax procumbens (Lin) aqueous leaf extract in rat aortic ring
- Inflammation
- Effects of cyclosporine and phenytoin on biomarker expressions in gingival fibroblasts of children and adults: an in vitro study
- Anti-inflammatory and analgesic activities of the methanol leaf extract of Phyllanthus amarus in some laboratory animals
- Oxidative Stress
- Ameliorative effect of diallyl trisulphide on arsenic-induced oxidative stress in rat erythrocytes and DNA damage in lymphocytes
- Anticholinesterase and antioxidative properties of water-extractable phytochemicals from some citrus peels
- Immune Response
- Temporal expression of IL-1β and IL-10 in rat skin, muscle, small bowel, and colon wounds: a correlative study
- Augmented primary humoral immune response and decreased cell-mediated immunity by Murraya koenigii in rats
- Analgesic, anti-inflammatory, and heme biomineralization inhibitory properties of Entada africana ethanol leaf extract with antiplasmodial activity against Plasmodium falciparum
- Hematological Profile
- Hematological profile in neonatal jaundice
- Effects of blood lead level on biochemical and hematological parameters in children with neurological diseases of Western Maharashtra, India
- Phytotherapy
- Antipsychotic property of solvent-partitioned fractions of Lonchocarpus cyanescens leaf extract in mice
- Aphrodisiac effect of aqueous root extract of Lecaniodiscus cupanioides in sexually impaired rats
- Virgin coconut oil protects against liver damage in albino rats challenged with the anti-folate combination, trimethoprim-sulfamethoxazole
- Metabolism
- Evaluation of in vitro aldose reductase inhibitory potential of alkaloidal fractions of Piper nigrum, Murraya koenigii, Argemone mexicana, and Nelumbo nucifera
