Interactions of the Aminoglycoside Neamine and 2-Deoxystreptamine with Copper(II) and Zinc(II)
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Yakup Baran
Abstract
Acid dissociation constants for the aminoglycosides neomycin and neamine and of 2-deoxystreptamine are reported. Solution NMR studies indicate that complexation with copper(II) and zinc(II) involves principally the primary amine donors, and formation constants with both neamine and 2-deoxystreptamine (2-DOS) and these metal ions are reported (at 25°C, I = 0.5 mol dm-3). Complexation studies probed by electrospray mass spectrometry identify both 1:1 and 1:2 species for Cu(II) and Zn(II) with 2-DOS, but only 1:1 species with neamine, consistent with behaviour in bulk solution. Preliminary formation kinetics of Cu(II) with neamine indicate rapid complexation at high pH but slower two-step processes near pH 7, consistent with complications in the thermodynamic determinations in the intermediate pH regime. Reaction of 2-DOS and neamine with Cu(II) in methanol appears as a single process, with the former occurring ~103-fold faster
© 2014 by Walter de Gruyter Berlin/Boston
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Artikel in diesem Heft
- Introducing The New Co-Editor Of Inorganic Reaction Mechanisms
- Kinetic and Mechanistic Studies of Substitution Reactions of Solvated Cobalt(II), Nickel(II), Copper(II) and Zinc(II) Ions with 2,2′:6′,2″-Terpyridine and Several 2,2′:6′,2″-Terpyridine Derivatives. Evidence for the Formation of Intermediates
- Activation Volumes for a Series of Spontaneous, Acidand Base-Catalysed Aquation Reactions of Aniono trans- [Co(MeNH2)(NH3)4X]2,1+ Complexes (X=Cl-, Br-,ΝO3-,SO42-)
- Interactions of the Aminoglycoside Neamine and 2-Deoxystreptamine with Copper(II) and Zinc(II)
- Kinetics of Oxidative Deamination and Decarboxylation of L-Asparagine by Alkaline Permanganate: a Mechanistic Approach
- Kinetics of Magnesium Incorporation into Water Soluble Porphyrins
- Micellar Effect on Chromium(VI) Oxidation of D-Glucose in the Presence and Absence of Picolinic Acid in Aqueous Media: A Kinetic Study
- Kinetics of Oxidation of Antimony(III) by Tetrachloroaurate(III) in Aqueous Hydrochloric Acid Media
