Altered methylarginine levels after surgery in subjects with multinodular goiter
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Suheyla Karaman
und
Husnu Alptekin
Abstract
Objectives
Thyroid disorders are important risk factor for cardiovascular diseases. Levels of methylarginines such as asymmetric dimethyl arginine (ADMA), L-monomethyl arginine (L-NMMA), symmetric dimethyl arginine (SDMA) are increase in cardiovascular diseases. Multinodular goiter (MNG) is the most common type of goiter in adults. To date, no study has been conducted to determine the levels of methylarginine in euthyroid MNG patients. Our aim in this study is to compare levels of methylarginines and related metabolites in the preoperative, postoperative MNG patients and controls.
Methods
Serum ADMA, SDMA, L-NMMA, homoarginine (hArg), arginine and citrulline concentrations were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS).
Results
ADMA (p<0.001), L-NMMA (p=0.002), l-arginine (p=0.006) and citrulline (p<0.001) levels were statistically significantly higher in preop group than postop group. ADMA (p=0.003), L-NMMA (p=0.003) levels were statistically significantly higher and SDMA/ADMA (p<0.001), hArg/ADMA (p<0.001) levels were statistically significantly lower in preop group than control group.
Conclusions
The levels of methylarginines and related metabolites altered in the euthyroid MNG patients compared to the control group, and more importantly, there were significant differences between the preop and postop groups. Therefore, these metabolites can be useful in the diagnosis and prognosis of thyroid disorders, even if thyroid hormone levels are normal.
Funding source: Selcuk University
Award Identifier / Grant number: 18202006
Acknowledgements
The authors thank the Selcuk University Scientific Research Projects Coordinator for funding this project.
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Research funding: This work was supported by elcuk University Scientific Research Projects Coordinator (grant number 18202006).
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors have no conflict of interests.
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Ethical approval: This study was approved by the ethics committee of Selcuk University (Number: 2017/22, Date:20/12/2017).
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© 2021 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Original Articles
- Investigating the relationship between insulin resistance and adipose tissue in a randomized Tehrani population
- Antitumor effects of Auraptene in 4T1 tumor‐bearing Balb/c mice
- Voluntary exercise improves sperm parameters in high fat diet receiving rats through alteration in testicular oxidative stress, mir-34a/SIRT1/p53 and apoptosis
- Assessment of AXL and mTOR genes expression in medullary thyroid carcinoma (MTC) cell line in relation with over expression of miR-144 and miR-34a
- Is there a relation between serum methylarginine levels and infertility?
- Evaluation of Y chromosome microdeletions and chromosomal anomalies in infertile men
- Threshold values of antibodies to estrogen, progesteron and benzo [a] pyrene as a risk factor for the development of endometriosis
- Altered methylarginine levels after surgery in subjects with multinodular goiter
- Effects of eight weeks exercise training on serum levels of adropin in male volleyball players
- Urinary bisphenol A in women with polycystic ovary syndrome – a possible suppressive effect on steroidogenesis?
- Complementary role of p57kip2 immunostaining in diagnosing hydatidiform mole subtypes
- Short Communications
- Circulating Inhibitory Factor 1 levels in adult patients with Prader–Willi syndrome
- Determinants of serum adiponectin levels: a cross-sectional study
- Case Report
- Prophylactic gonadectomy in 46 XY females; why, where and when?
- Review Article
- Is the beta estradiol receptor receiving enough attention for its metabolic importance in postmenopause?
Artikel in diesem Heft
- Frontmatter
- Original Articles
- Investigating the relationship between insulin resistance and adipose tissue in a randomized Tehrani population
- Antitumor effects of Auraptene in 4T1 tumor‐bearing Balb/c mice
- Voluntary exercise improves sperm parameters in high fat diet receiving rats through alteration in testicular oxidative stress, mir-34a/SIRT1/p53 and apoptosis
- Assessment of AXL and mTOR genes expression in medullary thyroid carcinoma (MTC) cell line in relation with over expression of miR-144 and miR-34a
- Is there a relation between serum methylarginine levels and infertility?
- Evaluation of Y chromosome microdeletions and chromosomal anomalies in infertile men
- Threshold values of antibodies to estrogen, progesteron and benzo [a] pyrene as a risk factor for the development of endometriosis
- Altered methylarginine levels after surgery in subjects with multinodular goiter
- Effects of eight weeks exercise training on serum levels of adropin in male volleyball players
- Urinary bisphenol A in women with polycystic ovary syndrome – a possible suppressive effect on steroidogenesis?
- Complementary role of p57kip2 immunostaining in diagnosing hydatidiform mole subtypes
- Short Communications
- Circulating Inhibitory Factor 1 levels in adult patients with Prader–Willi syndrome
- Determinants of serum adiponectin levels: a cross-sectional study
- Case Report
- Prophylactic gonadectomy in 46 XY females; why, where and when?
- Review Article
- Is the beta estradiol receptor receiving enough attention for its metabolic importance in postmenopause?
