Urinary bisphenol A in women with polycystic ovary syndrome – a possible suppressive effect on steroidogenesis?

Zora Lazúrová; Jana Figurová; Beáta Hubková; Jana Mašlanková; Ivica Lazúrová

doi:10.1515/hmbci-2020-0032

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Article

Urinary bisphenol A in women with polycystic ovary syndrome – a possible suppressive effect on steroidogenesis?

Zora Lazúrová , Jana Figurová , Beáta Hubková , Jana Mašlanková and Ivica Lazúrová

Published/Copyright: June 14, 2021

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From the journal Hormone Molecular Biology and Clinical Investigation Volume 42 Issue 3

Abstract

Objectives

There is a growing evidence indicating an impact of endocrine distrupting chemicals such as bisphenol A (BPA) on human reproduction. Its higher levels in serum or urine have been documented in women with polycystic ovary syndrome (PCOS), however the relationship to ovarian steroidogenesis remains unclear.

Aim of the study was to compare urinary BPA (U-BPA) concentrations among PCOS women and control group. Second aim was to assess the relationship of U-BPA to ovarian steroidogenesis in the group with PCOS.

Methods

Eighty six Caucasian women (age 28.5 ± 5.1 years) diagnosed with PCOS and 32 controls of age 24.9 ± 4.4 years were included in the study. Fasting blood samples were analyzed for biochemical parameters and steroid hormones. U-BPA was measured in the morning urine sample using high pressure liquid chromatography.

Results

PCOS women had significantly higher U-BPA as compared with control group (p=0.0001). Those with high levels of U-BPA (U-BPA ≥2.14 ug/g creatinine) demonstrated higher serum insulin (p=0.029) and HOMA IR (p=0.037), lower serum estrone (p=0.05), estradiol (p=0.0126), FSH (p=0.0056), and FAI (p=0.0088), as compared with low-BPA group (U- BPA <2.14 ug/g creatinine). In PCOS women, U-BPA positively correlated with age (p=0.0026; R²=0.17), negatively with estradiol (p=0.0001, R²=0.5), testosterone (p=0.0078, R²=0.15), free-testosterone (p=0.0094, R²=0.12) and FAI (p=0.0003, R²=0.32), respectively.

Conclusions

PCOS women have significantly higher U-BPA concentrations than healthy controls. U-BPA positively correlates with age and negatively with ovarian steroid hormones suggesting a possible suppressive effect of bisphenol A on ovarian steroidogenesis.

Keywords: bisphenol A; endocrine disruptor; environmental estrogen; polycystic ovary syndrome; steroidogenesis

Corresponding author: Zora Lazúrová, MD, Fourth Department of Internal Medicine, Medical Faculty, P.J. Šafárik University, Košice, Rastislavova 43, 04001 Košice, Slovakia, Phone: +421 55 6152248, E-mail: zora.lazurova@upjs.sk

Funding source: Agentúra Ministerstva školstva, vedy, výskumu a športu SR

Award Identifier / Grant number: VEGA 1/0364/17

Research funding: This work was supported by the Slovak Scientific Agency – project VEGA 1/0364/17.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Informed consent: Informed consent was obtained from all individuals included in this study.
Ethical approval: Study was approved by the Ethical committee of the University Hospital in Košice, Slovakia (03/2013).

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Received: 2020-05-24

Accepted: 2021-05-08

Published Online: 2021-06-14

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Articles in the same Issue

https://doi.org/10.1515/hmbci-2020-0032

Keywords for this article

bisphenol A; endocrine disruptor; environmental estrogen; polycystic ovary syndrome; steroidogenesis