Startseite Is the beta estradiol receptor receiving enough attention for its metabolic importance in postmenopause?
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Is the beta estradiol receptor receiving enough attention for its metabolic importance in postmenopause?

  • Débora Santos Rocha EMAIL logo und Luiz Carlos Kucharski
Veröffentlicht/Copyright: 3. März 2021
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Hormone Molecular Biology and Clinical Investigation
Aus der Zeitschrift Hormone Molecular Biology and Clinical Investigation Band 42 Heft 3

Abstract

The relationship between menopause and the development of metabolic diseases is well established. In postmenopause women, there is an expansion of visceral white adipose tissue (WATv), which highly contributes to the rise of circulating lipids. Meanwhile, muscle glucose uptake decreases and hepatic glucose production increases. Consequently, in the pancreas, lipotoxicity and glycotoxicity lead to deficient insulin production. These factors initiate an energy imbalance and enhance the probability of developing cardiovascular and metabolic diseases. Although the activation of estradiol receptors (ER) has been shown to be beneficial for the WAT stock pattern, leading to the insulin-sensitive phenotype, authors have described the risk of these receptors’ activation, contributing to neoplasia development. The selective activation of beta-type ER (ERβ) seems to be a promising strategy in the treatment of energy imbalance, acting on several tissues of metabolic importance and allowing an intervention with less risk for the development of estrogen-dependent neoplasia. However, the literature on the risks and benefits of selective ERβ activation still needs to increase. In this review, several aspects related to ERβ were considered, such as its physiological role in tissues of energy importance, beneficial effects, and risks of its stimulation during menopause. PubMed, SciELO, Cochrane, and Medline/Bireme databases were used in this study.

Highlights

  • – In menopause, the expansion of visceral white adipose tissue contributes to the rise of circulating lipids.

  • – Muscle glucose uptake decreases and hepatic glucose production increases in menopause.

  • – The energy imbalance and the enhanced probability of developing cardiovascular and metabolic diseases.

  • – The activation of estradiol receptors has been shown to be beneficial for the white adipose tissue stock pattern.

  • – It has been described the risk of estradiol receptors’ activation, contributing to neoplasia development.

  • – The selective activation of beta-type estradiol receptor seems to be a promising strategy, allowing an intervention with less risk for estrogen-dependent neoplasia.

  • – The literature on the risks and benefits of selective beta-estradiol receptor activation still needs to increase.

  • – Several physiological aspects related to estradiol beta-receptor need to be more investigated in tissues of energy importance.

Keywords: estradiol; estradiol receptor beta; hormonal therapy; menopause; metabolism; postmenopause
Corresponding author: Dr Débora Santos Rocha (doctoral degree), Physiology Department, Federal University of Rio Grande do Sul, Sarmento Leite, 500, 90050-170 Porto Alegre, Rio Grande do Sul, Brazil, Phone/Fax: +55 51 33083623, E-mail:

Funding source: Conselho Nacional de Desenvolvimento Científico e Tecnológico

  1. Research funding: This work was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors declare no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

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Received: 2020-11-09
Accepted: 2021-02-16
Published Online: 2021-03-03

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Original Articles
  3. Investigating the relationship between insulin resistance and adipose tissue in a randomized Tehrani population
  4. Antitumor effects of Auraptene in 4T1 tumor‐bearing Balb/c mice
  5. Voluntary exercise improves sperm parameters in high fat diet receiving rats through alteration in testicular oxidative stress, mir-34a/SIRT1/p53 and apoptosis
  6. Assessment of AXL and mTOR genes expression in medullary thyroid carcinoma (MTC) cell line in relation with over expression of miR-144 and miR-34a
  7. Is there a relation between serum methylarginine levels and infertility?
  8. Evaluation of Y chromosome microdeletions and chromosomal anomalies in infertile men
  9. Threshold values of antibodies to estrogen, progesteron and benzo [a] pyrene as a risk factor for the development of endometriosis
  10. Altered methylarginine levels after surgery in subjects with multinodular goiter
  11. Effects of eight weeks exercise training on serum levels of adropin in male volleyball players
  12. Urinary bisphenol A in women with polycystic ovary syndrome – a possible suppressive effect on steroidogenesis?
  13. Complementary role of p57kip2 immunostaining in diagnosing hydatidiform mole subtypes
  14. Short Communications
  15. Circulating Inhibitory Factor 1 levels in adult patients with Prader–Willi syndrome
  16. Determinants of serum adiponectin levels: a cross-sectional study
  17. Case Report
  18. Prophylactic gonadectomy in 46 XY females; why, where and when?
  19. Review Article
  20. Is the beta estradiol receptor receiving enough attention for its metabolic importance in postmenopause?
https://doi.org/10.1515/hmbci-2020-0079
Schlagwörter für diesen Artikel
estradiol; estradiol receptor beta; hormonal therapy; menopause; metabolism; postmenopause

Artikel in diesem Heft

  1. Frontmatter
  2. Original Articles
  3. Investigating the relationship between insulin resistance and adipose tissue in a randomized Tehrani population
  4. Antitumor effects of Auraptene in 4T1 tumor‐bearing Balb/c mice
  5. Voluntary exercise improves sperm parameters in high fat diet receiving rats through alteration in testicular oxidative stress, mir-34a/SIRT1/p53 and apoptosis
  6. Assessment of AXL and mTOR genes expression in medullary thyroid carcinoma (MTC) cell line in relation with over expression of miR-144 and miR-34a
  7. Is there a relation between serum methylarginine levels and infertility?
  8. Evaluation of Y chromosome microdeletions and chromosomal anomalies in infertile men
  9. Threshold values of antibodies to estrogen, progesteron and benzo [a] pyrene as a risk factor for the development of endometriosis
  10. Altered methylarginine levels after surgery in subjects with multinodular goiter
  11. Effects of eight weeks exercise training on serum levels of adropin in male volleyball players
  12. Urinary bisphenol A in women with polycystic ovary syndrome – a possible suppressive effect on steroidogenesis?
  13. Complementary role of p57kip2 immunostaining in diagnosing hydatidiform mole subtypes
  14. Short Communications
  15. Circulating Inhibitory Factor 1 levels in adult patients with Prader–Willi syndrome
  16. Determinants of serum adiponectin levels: a cross-sectional study
  17. Case Report
  18. Prophylactic gonadectomy in 46 XY females; why, where and when?
  19. Review Article
  20. Is the beta estradiol receptor receiving enough attention for its metabolic importance in postmenopause?
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