Startseite Indirectly determined hematology reference intervals for pediatric patients in Berlin and Brandenburg
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Indirectly determined hematology reference intervals for pediatric patients in Berlin and Brandenburg

  • Ingo Mrosewski EMAIL logo , Tobias Dähn , Jörg Hehde , Elena Kalinowski , Ilona Lindner , Thea Marie Meyer , Michael Olschinsky-Szermer , Jana Pahl , Monika Puls , Kristin Sachse und Rafael Switkowski
Veröffentlicht/Copyright: 14. Dezember 2021
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Clinical Chemistry and Laboratory Medicine (CCLM)
Aus der Zeitschrift Clinical Chemistry and Laboratory Medicine (CCLM) Band 60 Heft 3

Abstract

Objectives

Establishing direct reference intervals (RIs) for pediatric patients is a very challenging endeavor. Indirectly determined RIs can address this problem by utilization of existing clinical laboratory databases. In order to provide better laboratory services to the local pediatric population, we established population-specific hematology RIs via data mining.

Methods

Our laboratory information system (LIS) was searched for pediatric blood counts of patients aged from 0 days to 18 years, performed from 1st of January 2018 until 31st of March 2021. In total, 27,554 blood counts on our SYSMEX XN-9000 were initially identified. After application of pre-defined exclusion criteria, 18,531 sample sets remained. Age- and sex-specific RIs were established in accordance with International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) and Clinical & Laboratory Standards Institute (CLSI) recommendations.

Results

When compared to pediatric RIs supplied by other authors, the RIs determined specifically for pediatric patients from Berlin and Brandenburg showed several relevant differences, especially with regard to white blood cell counts (WBCs), red blood cell counts (RBCs), red cell distribution widths (RDW) and platelet counts (PLTs) within the distinct age groups. Additionally, alterations to several published age-specific partitions had to be made, while new sex-specific partitions were introduced for WBCs and PLTs.

Conclusions

Generic RIs from textbooks, manufacturer information and medical publications – even from nationwide or multicenter studies – commonly used in many laboratories might not reflect the specifics of local patient populations properly. RIs should be tailored to the serviced patient population whenever possible. Careful data mining appears to be suitable for this task.

Keywords: data mining; hematology; indirect reference range; pediatric; reference interval (RI); reference range
Corresponding author: Dr. Ingo Mrosewski, Department of Laboratory Medicine, MDI Limbach Berlin GmbH, Aroser Allee 84, 13407 Berlin, Germany, Phone: +49 30 443364 533, Fax: +49 30 443364 111, E-mail:

Acknowledgments

The authors thank Christin Renner for data retrieval from the laboratory information system.

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Not applicable.

  5. Ethical approval: Research involving human subjects complied with all relevant national regulations, institutional policies and is in accordance with the tenets of the Helsinki Declaration (as revised in 2013), and has been approved by the authors’ Institutional Review Board (Ärztekammer Berlin) or equivalent committee. (Register-Nr.: 225128: 03/2021).

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Received: 2021-07-30
Accepted: 2021-12-02
Published Online: 2021-12-14
Published in Print: 2022-02-23

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Obituary
  3. Dr Per Hyltoft Petersen: an appreciation
  4. Editorials
  5. Extrapolated normative GFR data for living kidney donation
  6. Effectiveness of interventions to improve test appropriateness
  7. Reviews
  8. The pathogenesis, epidemiology and biomarkers of susceptibility of pulmonary fibrosis in COVID-19 survivors
  9. S100B in cardiac surgery brain monitoring: friend or foe?
  10. Mini Review
  11. Blood lactate concentration in COVID-19: a systematic literature review
  12. Opinion Paper
  13. Commercial immunoassays for detection of anti-SARS-CoV-2 spike and RBD antibodies: urgent call for validation against new and highly mutated variants
  14. General Clinical Chemistry and Laboratory Medicine
  15. A randomized controlled study of biochemical tests in primary care: interventions can reduce the number of tests but usage does not become more appropriate
  16. A national surveillance program for evaluating new reagent lots in medical laboratories
  17. External quality assessment providers’ services appear to more impact the immunohaematology performance of laboratories than national regulatory and economic conditions
  18. International collaborative study to evaluate and calibrate two recombinant L chain Ferritin preparations for use as a WHO International Standard
  19. Method comparison of three serum free light chain assays on the Roche Cobas 6000 c501 chemistry analyzer
  20. Prospective urinary albumin/creatinine ratio for diagnosis, staging, and organ response assessment in renal AL amyloidosis: results from a large cohort of patients
  21. Analytical evaluation of the Nittobo Medical tartrate resistant acid phosphatase isoform 5b (TRACP-5b) EIA and comparison with IDS iSYS in different clinically defined populations
  22. Reference Values and Biological Variations
  23. Age-adapted percentiles of measured glomerular filtration in healthy individuals: extrapolation to living kidney donors over 65 years
  24. Indirectly determined hematology reference intervals for pediatric patients in Berlin and Brandenburg
  25. Hematology and Coagulation
  26. Monocyte distribution width (MDW): a useful biomarker to improve sepsis management in Emergency Department
  27. Diabetes
  28. A step towards optimal efficiency of HbA1c measurement as a first-line laboratory test: the TOP-HOLE (Towards OPtimal glycoHemOgLobin tEsting) project
  29. Labile glycated hemoglobin: an underestimated laboratory marker of short term glycemia
  30. Infectious Diseases
  31. Neutralizing antibody titers six months after Comirnaty vaccination: kinetics and comparison with SARS-CoV-2 immunoassays
  32. Letters to the Editors
  33. Molecular detection of SARS-CoV-2 eta VOI in Northern Italy: a case report
  34. Optimizing effectiveness of COVID-19 vaccination: will laboratory stewardship play a role?
  35. Measurement in different sample types may aid in detecting interferences and macrocomplexes affecting cardiac troponin measurements
  36. Which method to detect macrotroponin?
  37. Marked geographical variation in the prevalence of macroprolactinemia
  38. Pancreatic lipase assays: time for a change towards immunoassays?
  39. Analytical evaluation of the performances of a new procalcitonin immunoassay
  40. Necessity of harmonization of tissue transglutaminase IgA assays to align clinical decision making in coeliac disease
  41. A fortuitous but characteristic blood smear observation allowing a late diagnosis of MPS-VII
  42. Prognostic significance of blood-based multi-cancer detection in plasma cell-free DNA
https://doi.org/10.1515/cclm-2021-0853
Schlagwörter für diesen Artikel
data mining; hematology; indirect reference range; pediatric; reference interval (RI); reference range

Artikel in diesem Heft

  1. Frontmatter
  2. Obituary
  3. Dr Per Hyltoft Petersen: an appreciation
  4. Editorials
  5. Extrapolated normative GFR data for living kidney donation
  6. Effectiveness of interventions to improve test appropriateness
  7. Reviews
  8. The pathogenesis, epidemiology and biomarkers of susceptibility of pulmonary fibrosis in COVID-19 survivors
  9. S100B in cardiac surgery brain monitoring: friend or foe?
  10. Mini Review
  11. Blood lactate concentration in COVID-19: a systematic literature review
  12. Opinion Paper
  13. Commercial immunoassays for detection of anti-SARS-CoV-2 spike and RBD antibodies: urgent call for validation against new and highly mutated variants
  14. General Clinical Chemistry and Laboratory Medicine
  15. A randomized controlled study of biochemical tests in primary care: interventions can reduce the number of tests but usage does not become more appropriate
  16. A national surveillance program for evaluating new reagent lots in medical laboratories
  17. External quality assessment providers’ services appear to more impact the immunohaematology performance of laboratories than national regulatory and economic conditions
  18. International collaborative study to evaluate and calibrate two recombinant L chain Ferritin preparations for use as a WHO International Standard
  19. Method comparison of three serum free light chain assays on the Roche Cobas 6000 c501 chemistry analyzer
  20. Prospective urinary albumin/creatinine ratio for diagnosis, staging, and organ response assessment in renal AL amyloidosis: results from a large cohort of patients
  21. Analytical evaluation of the Nittobo Medical tartrate resistant acid phosphatase isoform 5b (TRACP-5b) EIA and comparison with IDS iSYS in different clinically defined populations
  22. Reference Values and Biological Variations
  23. Age-adapted percentiles of measured glomerular filtration in healthy individuals: extrapolation to living kidney donors over 65 years
  24. Indirectly determined hematology reference intervals for pediatric patients in Berlin and Brandenburg
  25. Hematology and Coagulation
  26. Monocyte distribution width (MDW): a useful biomarker to improve sepsis management in Emergency Department
  27. Diabetes
  28. A step towards optimal efficiency of HbA1c measurement as a first-line laboratory test: the TOP-HOLE (Towards OPtimal glycoHemOgLobin tEsting) project
  29. Labile glycated hemoglobin: an underestimated laboratory marker of short term glycemia
  30. Infectious Diseases
  31. Neutralizing antibody titers six months after Comirnaty vaccination: kinetics and comparison with SARS-CoV-2 immunoassays
  32. Letters to the Editors
  33. Molecular detection of SARS-CoV-2 eta VOI in Northern Italy: a case report
  34. Optimizing effectiveness of COVID-19 vaccination: will laboratory stewardship play a role?
  35. Measurement in different sample types may aid in detecting interferences and macrocomplexes affecting cardiac troponin measurements
  36. Which method to detect macrotroponin?
  37. Marked geographical variation in the prevalence of macroprolactinemia
  38. Pancreatic lipase assays: time for a change towards immunoassays?
  39. Analytical evaluation of the performances of a new procalcitonin immunoassay
  40. Necessity of harmonization of tissue transglutaminase IgA assays to align clinical decision making in coeliac disease
  41. A fortuitous but characteristic blood smear observation allowing a late diagnosis of MPS-VII
  42. Prognostic significance of blood-based multi-cancer detection in plasma cell-free DNA
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