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Dibenzofurans from the marine sponge-derived ascomycete Super1F1-09
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Mostafa E. Rateb
Veröffentlicht/Copyright:
16. November 2010
Abstract
Three dibenzofurans hitherto undescribed from nature and one known butyrolactone were isolated from the extract of the ascomycete Super1F1-09 isolated from the Fijian marine sponge Acanthella cavernosa. The isolated compounds were identified as 3,9-dimethyldibenzo[b,d]furan-1,7-diol (1), 3-(hydroxymethyl)-9-methyldibenzo[b,d]furan-1,7-diol (2), 1,7-dihydroxy-9-methyldibenzo[b,d]furan-3-carboxylic acid (3), and the known butyrolactone I (4) using different NMR spectroscopic techniques and accurate mass spectrometric analysis. 1 was synthesized together with structurally related dibenzofurans 6–8. 1 and 4 had moderate antibacterial activity toward Mycobacterium marinum and Staphylococcus aureus, whereas 2 and 3 proved inactive. In addition, all compounds had moderate inhibitory properties against epidermal growth factor receptor tyrosine kinase.
Keywords: Acanthella cavernosa; antibacterial activity; ascomycete; dibenzofurans; sponge-derived fungal metabolites; tyrosine kinase inhibition
Received: 2010-3-1
Accepted: 2010-8-27
Published Online: 2010-11-16
Published Online: 2010-11-16
Published in Print: 2010-12-01
©2010 by Walter de Gruyter Berlin New York
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Artikel in diesem Heft
- Guest editorial
- 11th International Marine and Freshwater Mycology Symposium, Taichung, Taiwan R.O.C., November 2009
- Review
- A review on deep-sea fungi: occurrence, diversity and adaptations
- Research articles
- Sedecimiella taiwanensis gen. et sp. nov., a marine mangrove fungus in the Hypocreales (Hypocreomycetidae, Ascomycota)
- Dibenzofurans from the marine sponge-derived ascomycete Super1F1-09
- Antimicrobial activities of marine fungi from Malaysia
- Diversity and abundance of lignicolous marine fungi from the east and west coasts of Peninsular Malaysia and Sabah (Borneo Island)
- Fungal colonization and breakdown of sedge (Cyperus malaccensis Lam.) in an Indian mangrove
- Occurrence and distribution of fungi in a mangrove forest on Siargao Island, Philippines
- Biodiversity of marine fungi in Malaysian mangroves
- Endophytic fungi from mangrove plant species of Thailand: their antimicrobial and anticancer potentials
- Fungal communities in bunker C oil-impacted sites off southern Guimaras, Philippines: a post-spill assessment of Solar 1 oil spill
- Potential use of marine arenicolous ascomycetes as bioindicators of ecosystem disturbance on sandy Cancun beaches: Corollospora maritima as a candidate species
- Effects of Cu(II) and Zn(II) on growth and cell morphology of thraustochytrids isolated from fallen mangrove leaves in Taiwan
- Marine-derived fungi from Kappaphycus alvarezii and K. striatum as potential causative agents of ice-ice disease in farmed seaweeds
- Short communication
- Fungal diversity in bottom sediments of the Kara Sea
- Reviewer acknowledgement Bot. Mar. volume 53 (2010)
Schlagwörter für diesen Artikel
Acanthella cavernosa;
antibacterial activity;
ascomycete;
dibenzofurans;
sponge-derived fungal metabolites;
tyrosine kinase inhibition
Artikel in diesem Heft
- Guest editorial
- 11th International Marine and Freshwater Mycology Symposium, Taichung, Taiwan R.O.C., November 2009
- Review
- A review on deep-sea fungi: occurrence, diversity and adaptations
- Research articles
- Sedecimiella taiwanensis gen. et sp. nov., a marine mangrove fungus in the Hypocreales (Hypocreomycetidae, Ascomycota)
- Dibenzofurans from the marine sponge-derived ascomycete Super1F1-09
- Antimicrobial activities of marine fungi from Malaysia
- Diversity and abundance of lignicolous marine fungi from the east and west coasts of Peninsular Malaysia and Sabah (Borneo Island)
- Fungal colonization and breakdown of sedge (Cyperus malaccensis Lam.) in an Indian mangrove
- Occurrence and distribution of fungi in a mangrove forest on Siargao Island, Philippines
- Biodiversity of marine fungi in Malaysian mangroves
- Endophytic fungi from mangrove plant species of Thailand: their antimicrobial and anticancer potentials
- Fungal communities in bunker C oil-impacted sites off southern Guimaras, Philippines: a post-spill assessment of Solar 1 oil spill
- Potential use of marine arenicolous ascomycetes as bioindicators of ecosystem disturbance on sandy Cancun beaches: Corollospora maritima as a candidate species
- Effects of Cu(II) and Zn(II) on growth and cell morphology of thraustochytrids isolated from fallen mangrove leaves in Taiwan
- Marine-derived fungi from Kappaphycus alvarezii and K. striatum as potential causative agents of ice-ice disease in farmed seaweeds
- Short communication
- Fungal diversity in bottom sediments of the Kara Sea
- Reviewer acknowledgement Bot. Mar. volume 53 (2010)
