Labor induction in preeclampsia: Is misoprostol more effective than dinoprostone?
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Olav Lapaire
Abstract
Objective: To compare the efficacy of vaginal misoprostol versus dinoprostone for induction of labor (IOL) in patients with preeclampsia according to the WHO criteria.
Study design: Ninety-eight patients were retrospectively analyzed. A total of 47 patients received 3 mg dinoprostone suppositories every 6 h (max. 6 mg/24 h) whereas 51 patients in the misoprostol group received either 50 μg misoprostol vaginally every 12 h, or 25 μg every 6 h (max. 100 μg/24 h). Primary outcomes were vaginal delivery within 24 and 48 h, respectively.
Results: The probability of delivering within 48 h was more than three-fold higher in the misoprostol than in the dinoprostone group: odds ratio (OR)=3.48; 95% confidence interval (CI) 1.24, 10.30, whereas no significant difference was observed within 24 h (P=0.34). No correlation was seen between a ripe cervix prior to IOL and delivery within 24/48 h (P=0.33 and P=1.0, respectively). More cesarean sections were performed in the dinoprostone group due to failed IOL (P=0.0009). No significant differences in adverse maternal outcome were observed between both study groups, whereas more neonates (12 vs. 6) of the dinoprostone group were admitted to the NICU (P=0.068).
Conclusion: This study suggests that misoprostol may have some advantages compared to dinoprostone, including improved efficacy and lower cost of the drug, even in cases of preeclampsia.
©2007 by Walter de Gruyter Berlin New York
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Artikel in diesem Heft
- European consensus guidelines on the management of neonatal respiratory distress syndrome
- Hypogastric artery ligation for severe hemorrhage in obstetric patients
- Hypogastric artery ligation: a stitch in time
- Labor induction in preeclampsia: Is misoprostol more effective than dinoprostone?
- Neurokinin B levels in maternal and umbilical cord blood in preeclamptic and normal pregnancies
- Intrauterine infection induced oligodendrocyte injury and inducible nitric oxide synthase expression in the developing rat brain
- Chaotic indices and canonical ensemble of heart rate patterns in small-for-gestational age fetuses
- The cisterna magna size in normal second-trimester fetuses
- Type and number of sites colonized by fungi and risk of progression to invasive fungal infection in preterm neonates in neonatal intensive care unit
- Serratia marcescens bacteremia – an indicator for outbreak management and heightened surveillance
- A device for adsorbing unbound, unconjugated bilirubin and its effects in vitro and in a hyperbilirubinemic newborn piglet
- The influence of thermal environment on pulmonary hemodynamic acclimation to extrauterine life in normal full-term neonates
- Justifying the “Folate trap” in folic acid fortification programs
- Immune functions after severe twin-twin transfusion syndrome
- Are recurrent hyperglycemic episodes and median blood glucose level a prognostic factor for increased morbidity and mortality in premature infants ≤1500 g?
- Gastroschisis: primary closure using umbilical cord strengthened by a polypropylene mesh
- Neonatal antibiotic prophylaxis for the prevention of early- and late-onset Group B streptococcal sepsis
- Reply
- Management of a rare cause of neonatal airway obstruction: cervical teratoma
- Congress Calendar
