A device for adsorbing unbound, unconjugated bilirubin and its effects in vitro and in a hyperbilirubinemic newborn piglet
-
Keishi Miwa
Abstract
Aims: A novel blood purification material that we previously reported as a superantigen- and cytokine-adsorbing device (SCAD) was evaluated for its ability to adsorb unbound, unconjugated bilirubin (UUBil) in vitro and in vivo.
Methods: In albumin-containing buffer, UUBil was dissolved and circulated through the SCAD column. Also, bilirubin was infused into low-body weight newborn piglets and hemoperfused for 3 h over SCAD columns.
Results: In albumin-containing buffer, concentration of bilirubin decreased from 34 to 0.6 mg/dL within 5 h and the SCAD fiber turned brown, indicating that bilirubin was adsorbed onto the surface of the adsorbent and was not degraded during the circulation. Using the hyperbilirubinemia swine, clearances of total bilirubin (TBil), direct bilirubin (DBil), and indirect bilirubin (IdBil) were significantly higher (P<0.01) in the SCAD group compared with the control group. The clearances of TBil, DBil, and IdBil at 3 h after the initiation of the bilirubin infusion were 0.47, 0.53, and 0.45 mL/min, respectively, at a blood flow rate of 2.5 mL/min, and this result indicates that almost 20% of bilirubins were adsorbed to the SCAD column in a single passage.
Conclusion: These results provide initial evidence that SCAD treatment is effective in the removal of UUBil and can be performed safely in newborn animals.
©2007 by Walter de Gruyter Berlin New York
Articles in the same Issue
- European consensus guidelines on the management of neonatal respiratory distress syndrome
- Hypogastric artery ligation for severe hemorrhage in obstetric patients
- Hypogastric artery ligation: a stitch in time
- Labor induction in preeclampsia: Is misoprostol more effective than dinoprostone?
- Neurokinin B levels in maternal and umbilical cord blood in preeclamptic and normal pregnancies
- Intrauterine infection induced oligodendrocyte injury and inducible nitric oxide synthase expression in the developing rat brain
- Chaotic indices and canonical ensemble of heart rate patterns in small-for-gestational age fetuses
- The cisterna magna size in normal second-trimester fetuses
- Type and number of sites colonized by fungi and risk of progression to invasive fungal infection in preterm neonates in neonatal intensive care unit
- Serratia marcescens bacteremia – an indicator for outbreak management and heightened surveillance
- A device for adsorbing unbound, unconjugated bilirubin and its effects in vitro and in a hyperbilirubinemic newborn piglet
- The influence of thermal environment on pulmonary hemodynamic acclimation to extrauterine life in normal full-term neonates
- Justifying the “Folate trap” in folic acid fortification programs
- Immune functions after severe twin-twin transfusion syndrome
- Are recurrent hyperglycemic episodes and median blood glucose level a prognostic factor for increased morbidity and mortality in premature infants ≤1500 g?
- Gastroschisis: primary closure using umbilical cord strengthened by a polypropylene mesh
- Neonatal antibiotic prophylaxis for the prevention of early- and late-onset Group B streptococcal sepsis
- Reply
- Management of a rare cause of neonatal airway obstruction: cervical teratoma
- Congress Calendar
Articles in the same Issue
- European consensus guidelines on the management of neonatal respiratory distress syndrome
- Hypogastric artery ligation for severe hemorrhage in obstetric patients
- Hypogastric artery ligation: a stitch in time
- Labor induction in preeclampsia: Is misoprostol more effective than dinoprostone?
- Neurokinin B levels in maternal and umbilical cord blood in preeclamptic and normal pregnancies
- Intrauterine infection induced oligodendrocyte injury and inducible nitric oxide synthase expression in the developing rat brain
- Chaotic indices and canonical ensemble of heart rate patterns in small-for-gestational age fetuses
- The cisterna magna size in normal second-trimester fetuses
- Type and number of sites colonized by fungi and risk of progression to invasive fungal infection in preterm neonates in neonatal intensive care unit
- Serratia marcescens bacteremia – an indicator for outbreak management and heightened surveillance
- A device for adsorbing unbound, unconjugated bilirubin and its effects in vitro and in a hyperbilirubinemic newborn piglet
- The influence of thermal environment on pulmonary hemodynamic acclimation to extrauterine life in normal full-term neonates
- Justifying the “Folate trap” in folic acid fortification programs
- Immune functions after severe twin-twin transfusion syndrome
- Are recurrent hyperglycemic episodes and median blood glucose level a prognostic factor for increased morbidity and mortality in premature infants ≤1500 g?
- Gastroschisis: primary closure using umbilical cord strengthened by a polypropylene mesh
- Neonatal antibiotic prophylaxis for the prevention of early- and late-onset Group B streptococcal sepsis
- Reply
- Management of a rare cause of neonatal airway obstruction: cervical teratoma
- Congress Calendar
