Startseite Detection of parvovirus B19, cytomegalovirus and enterovirus infections in cases of intrauterine fetal death
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Detection of parvovirus B19, cytomegalovirus and enterovirus infections in cases of intrauterine fetal death

  • Karin Petersson , Oscar Norbeck , Magnus Westgren und Kristina Broliden
Veröffentlicht/Copyright: 1. Juni 2005
Journal of Perinatal Medicine
Aus der Zeitschrift Band 32 Heft 6

Abstract

Aims: Maternal infections with parvovirus B19, cytomegalovirus (CMV) and enterovirus have been associated with intrauterine fetal death (IUFD), but the incidence of these infections is not clear. This prospective study was conducted to estimate this incidence.

Methods: A prospective study of 38 months was conducted on cases of IUFD referred to Huddinge University Hospital, Stockholm, Sweden. Placental biopsies, fetal blood and amniotic fluid were collected from cases of IUFD (n=52). Placental biopsies from normal pregnancies at term (n=53) were used as controls. These tissues were examined for parvovirus B19 DNA, CMV DNA and enterovirus RNA using polymerase chain reaction (PCR). Maternal viral serology was measured in 46 cases and virus isolation for enterovirus in maternal stool samples was performed in 31 cases.

Results: Viral nucleic acid was recovered in at least one tissue sample from six cases of fetal death (parvovirus B19 in two cases, CMV in three and enterovirus in one), while all placental biopsies from controls were found negative. Serological signs of primary maternal infection were found in two of the cases, and virus isolation for enterovirus was negative in all samples examined.

Conclusion: Parvovirus B19, CMV and enterovirus may be considered as etiologic agents in cases of fetal death. PCR on placental and/or fetal tissue improves diagnostic accuracy for these infections.

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Corresponding author: Dr Kristina Broliden, MD, PhD, Associate Professor, Division of Clinical Virology, F68 Karolinska Institutet, Karolinska University Hospital, Huddinge SE-141 86 Huddinge/Sweden. Tel.: +46-8-58-58-79-46, E-mail:

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Published Online: 2005-06-01
Published in Print: 2004-11-04

© Walter de Gruyter

Artikel in diesem Heft

  1. Author Index
  2. Subject Index
  3. Contents
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  5. Breech presenting twin A: is vaginal delivery safe?
  6. Maternal serum interleukin-1β, -6 and -8 levels and potential determinants in pregnancy and peripartum
  7. Comparison between HELLP syndrome, chronic hypertension, and superimposed preeclampsia on chronic hypertension without HELLP syndrome
  8. Fetal scalp pH and ST analysis of the fetal ECG as an adjunct to CTG. A multi-center, observational study
  9. Effects of nitric oxide and prostacyclin on hemodynamic response by big endothelin-1 in near term fetal sheep
  10. Strategy for management of newborns with cervical teratoma
  11. Predicting neonatal outcomes: birthweight, body mass index or ponderal index?
  12. Markers of platelets activation, CD 62P and soluble P-selectin in healthy term neonates
  13. Detection of parvovirus B19, cytomegalovirus and enterovirus infections in cases of intrauterine fetal death
  14. Plasma endothelin-1 and clinical manifestations of neonatal sepsis
  15. Noncompaction of the left ventricular myocardium diagnosed in pregnant woman and neonate
  16. Ventricular bigeminy misdiagnosed as fetal bradycardia by cardiotocography – the value of non-invasive fetal electrocardiography
  17. Prolonged fetal bradycardia as the presenting clinical sign in Streptococcus agalactiae chorioamnionitis
  18. Changes of blood pressure and heart rate variability precede a grand mal seizure in a pregnant woman
  19. Myocardial infarction in early pregnancy
  20. The baby and the bathwater – a comment
  21. Reply to the opinion paper “The baby or the bathwater: which one should be discarded?”
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