Home Maternal serum interleukin-1β, -6 and -8 levels and potential determinants in pregnancy and peripartum
Article
Licensed
Unlicensed Requires Authentication

Maternal serum interleukin-1β, -6 and -8 levels and potential determinants in pregnancy and peripartum

  • Gundula Hebisch , Peruka M. Neumaier-Wagner , Renate Huch and Ursula von Mandach
Published/Copyright: June 1, 2005
Journal of Perinatal Medicine
From the journal Volume 32 Issue 6

Abstract

Aims: To measure maternal serum interleukins (IL) in pregnancy, delivery and early puerperium, and to identify their potential determinants.

Methods: Prospective longitudinal measures of serum IL-1β, IL-6 and IL-8 in 38 healthy pregnant women at antenatal visits, through labor and delivery, with clinical correlates (infection, vaginal hemorrhage and anemia) recorded by questionnaire.

Results: Pregnancy IL levels remained consistently low. IL-1β increased shortly before delivery, then returned to pregnant levels, except where blood loss exceeded 500 ml. IL-6 and IL-8 rose at labor onset and exceeded pregnancy levels through postpartum day three. Postpartum IL-6 was higher after non-elective cesarean section than after spontaneous delivery (P < 0.0001), and where blood loss exceeded 500 ml. IL-6 and IL-8 were higher with systemic infection during delivery (P < 0.0001) and on postpartum day one (P < 0.05); IL-8 was higher in anemia (delivery: P < 0.005; postpartum day 1: P < 0.05). Differences due to delivery mode and systemic infection remained significant after correction for other conditions.

Conclusions: Labor-dependent inflammation increases all IL levels at delivery. Further studies with larger sample sizes are required to establish reference values differentiating physiology from pathology as an aid to peripartum management.

:

Corresponding author: Gundula Hebisch, M.D., Gesundheitszentrum für die Frau Bankstraße, CH-8610 Uster. Tel.:+41-43-444-2000, Fax.:+41-43-444-2001, E-mail:

References

1 Alvarez-de-la-Rosa M, FJ Rebollo, R Codoceo, A Gonzalez Gonzalez: Maternal serum interleukin 1, 2, 6, 8 and interleukin-2 receptor levels in preterm labor and delivery. Eur J Obstet Gynecol Reprod Biol88 (2000) 57Search in Google Scholar

2 Arntzen KJ, E Lien, R Austgulen: Maternal serum levels of interleukin-6 and clinical characteristics of normal delivery at term. Acta Obstet Gynecol Scand76 (1997) 55Search in Google Scholar

3 Bahar AM, HW Ghalib, RA Moosa, ZM Zaki, C Thomas, OA Nabri: Maternal serum interleukin-6, interleukin-8, tumor necrosis factor-alpha and interferon-gamma in preterm labor. Acta Obstet Gynecol Scand82 (2003) 543Search in Google Scholar

4 Cauci S, S Guaschino, D De Aloysio, S Driussi, D De Santo, P Penacchioni, et al.: Interrelationships of interleukin-8 with interleukin-1β and neutrophils in vaginal fluid of healthy and bacterial vaginosis positive women. Mol Hum Reprod9 (2003) 53Search in Google Scholar

5 Denison FC, RW Kelly, AA Calder: Differential secretion of chemokines from peripheral blood in pregnant compared with non-pregnant women. J Reprod Immunol34 (1997) 225Search in Google Scholar

6 Denison FC, RW Kelly, AA Calder, SC Riley: Cytokine secretion by human fetal membranes, deciduas and placenta at term. Hum Reprod12 (1998) 3560Search in Google Scholar

7 Dinarello CA: Biologic basis for interleukin-1 in disease. Blood87 (1996) 209510.1182/blood.V87.6.2095.bloodjournal8762095Search in Google Scholar

8 Gravett MG, SS Witkin, GJ Haluska, JL Edwards, MJ Cook, MJ Novy: An experimental model for intraamniotic infection and preterm labor in rhesus monkeys. Am J Obstet Gynecol171 (1994) 1660Search in Google Scholar

9 Halgunset J, H Johnsen, AM Kjollesdal, E Qvigstad, T Espevik, R Austgulen: Cytokine levels in amniotic fluid and inflammatory changes in the placenta from normal deliveries at term. Eur J Obstet Gynecol Reprod Biol56 (1994) 153Search in Google Scholar

10 Hebisch G, AA Grauaug, PM Neumaier-Wagner, T Stallmach, A Huch, R Huch: The relationship between cervical dilatation, interleukin-6 and interleukin-8 during term labor. Acta Obstet Gynecol Scand8 (2001) 840Search in Google Scholar

11 Heresbach D, JB Letourneur, I Bahon, M Pagenault, YM Guillou, F Dyard, et al.: Value of early blood Th-1 cytokine determination in predicting severity of acute pancreatitis. Scand J Gastroenterol33 (1998) 554Search in Google Scholar

12 Kelly RW, R Leask, AA Calder: Choriodecidual production of interleukin-8 and mechanisms of parturition. Lancet339 (1992) 776Search in Google Scholar

13 Laham N, GE Rice, GJ Bishop, C Ransome, SP Brennecke: Interleukin-8 concentrations in amniotic fluid and peripheral venous plasma during human pregnancy and parturition. Acta Endocrinol129 (1993) 220Search in Google Scholar

14 Laham N, SP Brennecke, K Bendtzen, GE Rice: Associated-associated increase in interleukin-1 alpha release in vitro by human gestational tissues. J Endocrinol150 (1996) 515Search in Google Scholar

15 Laham N, SP Brennecke, GE Rice: Interleukin-8 release from human gestational tissue explants: effects of gestation, labor, and chorioamnionitis. Biol Reprod61 (1999) 823Search in Google Scholar

16 Makhseed M, R Raghupathy, F Azizieh, R Farhat, N Hassan, A Bandar: Circulating cytokines and CD30 in normal human pregnancy and recurrent spontaneous abortions. Hum Reprod15 (2000) 2011Search in Google Scholar

17 Makhseed M, R Raghupathy, S El-Shazly, F Azizieh, JA Al-Harmi, MM Al-Azemi: Pro-inflammatory maternal cytokine profile in preterm delivery. Am J Reprod Immunol49 (2003) 3088Search in Google Scholar

18 Maradny EE, N Kanayama, A Halim, K Maehara, T Terao: Stretching of fetal membranes increases the concentration of interleukin-8 and collagenase activity. Am J Obstet Gynecol174 (1996) 843Search in Google Scholar

19 Murtha AP, PC Greig, CE Jimmerson, WN Herbert: Maternal serum interleukin-6 concentration as a marker for impending preterm delivery. Obstet Gynecol91 (1998) 161Search in Google Scholar

20 Nieman DC: Immune response to heavy exertion. J Appl Physiol82 (1997) 1385510.1152/jappl.1997.82.5.1385Search in Google Scholar PubMed

21 Roilides E, T Sein, R Schaufele, SJ Chanock, TJ Walsh: Increased serum concentrations of interleukin-10 in patients with hepatosplenic candidiasis. J Infect Dis178 (1998) 589Search in Google Scholar

22 Romero R, ST Parvizi, E Oyarzun, M Mazor, YK Wu, C Avila: Amniotic fluid interleukin-1 in spontaneous labor at term. J Reprod Med35 (1990) 235Search in Google Scholar

23 Romero R, R Gomez, F Ghezzi, BH Yoon, M Mazor, SS Edwin, et al.: A fetal systemic inflammatory response is followed by the spontaneous onset of preterm parturition. Am J Obstet Gynecol179 (1998) 186Search in Google Scholar

24 Santhanam U, C Avila, R Romero, H Viguet, N Ida, S Sakurai, et al.: Cytokines in normal and abnormal parturition: elevated amniotic fluid interleukin-6 levels in women with premature rupture of membranes associated with intrauterine infection. Cytokine3 (1991) 155Search in Google Scholar

25 Sennstrom MB, G Ekman, G Westergren-Thorsson, A Malmstrom, B Bystrom, U Endresen, et al.: Human cervical ripening, an inflammatory process mediated by cytokines. Mol Hum Reprod6 (2000) 375Search in Google Scholar

26 Shimaoka Y, Y Hidaka, H Tada, T Nakamura, N Mitsuda, Y Morimoto, et al.: Changes in cytokine production during and after normal pregnancy. Am J Reprod Immunol44 (2000) 1433Search in Google Scholar

27 Stallmach T, G Hebisch, HI Joller-Jemelka, P Orban, J Schwaller, M Engelmann: Cytokine production and visualized effects in the feto-maternal unit. Quantitative and topographic data on cytokines during intrauterine disease. Lab Invest73 (1995) 384Search in Google Scholar

28 Vassiliadis S, A Ranella, L Papadimitriou, A Makrygiannakis, I Athanassakis: Serum levels of pro- and anti-inflammatory cytokines in non-pregnant women, during pregnancy, labor and abortion. Mediators Inflamm7 (1998) 69Search in Google Scholar

29 Yudin MH, DV Landers, L Meyn, SL Hillier: Clinical and cervical cytokine response to treatment with oral or vaginal metronidazole for bacterial vaginosis during pregnancy: a randomized trial. Obstet Gynecol102 (2003) 527Search in Google Scholar

Published Online: 2005-06-01
Published in Print: 2004-11-04

© Walter de Gruyter

Articles in the same Issue

  1. Author Index
  2. Subject Index
  3. Contents
  4. Difficult delivery of the impacted fetal head during cesarean section: intraoperative disengagement dystocia
  5. Breech presenting twin A: is vaginal delivery safe?
  6. Maternal serum interleukin-1β, -6 and -8 levels and potential determinants in pregnancy and peripartum
  7. Comparison between HELLP syndrome, chronic hypertension, and superimposed preeclampsia on chronic hypertension without HELLP syndrome
  8. Fetal scalp pH and ST analysis of the fetal ECG as an adjunct to CTG. A multi-center, observational study
  9. Effects of nitric oxide and prostacyclin on hemodynamic response by big endothelin-1 in near term fetal sheep
  10. Strategy for management of newborns with cervical teratoma
  11. Predicting neonatal outcomes: birthweight, body mass index or ponderal index?
  12. Markers of platelets activation, CD 62P and soluble P-selectin in healthy term neonates
  13. Detection of parvovirus B19, cytomegalovirus and enterovirus infections in cases of intrauterine fetal death
  14. Plasma endothelin-1 and clinical manifestations of neonatal sepsis
  15. Noncompaction of the left ventricular myocardium diagnosed in pregnant woman and neonate
  16. Ventricular bigeminy misdiagnosed as fetal bradycardia by cardiotocography – the value of non-invasive fetal electrocardiography
  17. Prolonged fetal bradycardia as the presenting clinical sign in Streptococcus agalactiae chorioamnionitis
  18. Changes of blood pressure and heart rate variability precede a grand mal seizure in a pregnant woman
  19. Myocardial infarction in early pregnancy
  20. The baby and the bathwater – a comment
  21. Reply to the opinion paper “The baby or the bathwater: which one should be discarded?”
Downloaded on 15.9.2025 from https://www.degruyterbrill.com/document/doi/10.1515/JPM.2004.131/html
Scroll to top button