Maternal serum interleukin-1β, -6 and -8 levels and potential determinants in pregnancy and peripartum
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Gundula Hebisch
Abstract
Aims: To measure maternal serum interleukins (IL) in pregnancy, delivery and early puerperium, and to identify their potential determinants.
Methods: Prospective longitudinal measures of serum IL-1β, IL-6 and IL-8 in 38 healthy pregnant women at antenatal visits, through labor and delivery, with clinical correlates (infection, vaginal hemorrhage and anemia) recorded by questionnaire.
Results: Pregnancy IL levels remained consistently low. IL-1β increased shortly before delivery, then returned to pregnant levels, except where blood loss exceeded 500 ml. IL-6 and IL-8 rose at labor onset and exceeded pregnancy levels through postpartum day three. Postpartum IL-6 was higher after non-elective cesarean section than after spontaneous delivery (P < 0.0001), and where blood loss exceeded 500 ml. IL-6 and IL-8 were higher with systemic infection during delivery (P < 0.0001) and on postpartum day one (P < 0.05); IL-8 was higher in anemia (delivery: P < 0.005; postpartum day 1: P < 0.05). Differences due to delivery mode and systemic infection remained significant after correction for other conditions.
Conclusions: Labor-dependent inflammation increases all IL levels at delivery. Further studies with larger sample sizes are required to establish reference values differentiating physiology from pathology as an aid to peripartum management.
References
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© Walter de Gruyter
Articles in the same Issue
- Author Index
- Subject Index
- Contents
- Difficult delivery of the impacted fetal head during cesarean section: intraoperative disengagement dystocia
- Breech presenting twin A: is vaginal delivery safe?
- Maternal serum interleukin-1β, -6 and -8 levels and potential determinants in pregnancy and peripartum
- Comparison between HELLP syndrome, chronic hypertension, and superimposed preeclampsia on chronic hypertension without HELLP syndrome
- Fetal scalp pH and ST analysis of the fetal ECG as an adjunct to CTG. A multi-center, observational study
- Effects of nitric oxide and prostacyclin on hemodynamic response by big endothelin-1 in near term fetal sheep
- Strategy for management of newborns with cervical teratoma
- Predicting neonatal outcomes: birthweight, body mass index or ponderal index?
- Markers of platelets activation, CD 62P and soluble P-selectin in healthy term neonates
- Detection of parvovirus B19, cytomegalovirus and enterovirus infections in cases of intrauterine fetal death
- Plasma endothelin-1 and clinical manifestations of neonatal sepsis
- Noncompaction of the left ventricular myocardium diagnosed in pregnant woman and neonate
- Ventricular bigeminy misdiagnosed as fetal bradycardia by cardiotocography – the value of non-invasive fetal electrocardiography
- Prolonged fetal bradycardia as the presenting clinical sign in Streptococcus agalactiae chorioamnionitis
- Changes of blood pressure and heart rate variability precede a grand mal seizure in a pregnant woman
- Myocardial infarction in early pregnancy
- The baby and the bathwater – a comment
- Reply to the opinion paper “The baby or the bathwater: which one should be discarded?”
Articles in the same Issue
- Author Index
- Subject Index
- Contents
- Difficult delivery of the impacted fetal head during cesarean section: intraoperative disengagement dystocia
- Breech presenting twin A: is vaginal delivery safe?
- Maternal serum interleukin-1β, -6 and -8 levels and potential determinants in pregnancy and peripartum
- Comparison between HELLP syndrome, chronic hypertension, and superimposed preeclampsia on chronic hypertension without HELLP syndrome
- Fetal scalp pH and ST analysis of the fetal ECG as an adjunct to CTG. A multi-center, observational study
- Effects of nitric oxide and prostacyclin on hemodynamic response by big endothelin-1 in near term fetal sheep
- Strategy for management of newborns with cervical teratoma
- Predicting neonatal outcomes: birthweight, body mass index or ponderal index?
- Markers of platelets activation, CD 62P and soluble P-selectin in healthy term neonates
- Detection of parvovirus B19, cytomegalovirus and enterovirus infections in cases of intrauterine fetal death
- Plasma endothelin-1 and clinical manifestations of neonatal sepsis
- Noncompaction of the left ventricular myocardium diagnosed in pregnant woman and neonate
- Ventricular bigeminy misdiagnosed as fetal bradycardia by cardiotocography – the value of non-invasive fetal electrocardiography
- Prolonged fetal bradycardia as the presenting clinical sign in Streptococcus agalactiae chorioamnionitis
- Changes of blood pressure and heart rate variability precede a grand mal seizure in a pregnant woman
- Myocardial infarction in early pregnancy
- The baby and the bathwater – a comment
- Reply to the opinion paper “The baby or the bathwater: which one should be discarded?”