Objectives The incidence of ischemic stroke continues to rise globally, however, regular physical activity before stroke onset significantly lowers its occurrence. Here, we evaluated whether low-intensity exercise preconditioning can improve neurological outcome, cerebral micro-angiogenesis, and neuronal injury in mice subjected to ischemic stroke. Methods 12-week-old C57BL/6J male mice were assigned to three groups: Sham group, transient middle cerebral artery occlusion (tMCAO group), and exercise preconditioning and tMCAO (Ex+tMCAO group). Ex+tMCAO group were underwent 4 weeks of low-intensity treadmill preconditioning for 5 days a week for 4 weeks (running speed, 10 m/min; running duration, 1 h/day) before ischemic stroke surgery. Behavioral tests were assessed 24 h after ischemic stroke to verify the effects of exercise preconditioning on acute recovery following ischemic stroke. Various techniques were used to evaluate ischemic infarct size and explore pathological changes in tissue morphology after ischemic stroke. In addition, to detect whether exercise preconditioning influenced levels of inflammatory cytokines, real-time PCR was performed on the infarcted brain tissues. Results Low-intensity exercise preconditioning significantly reduced infarct size, increased cerebral microvascular density, and ameliorated neuronal apoptosis induced by tMCAO. Moreover, the apoptosis evoked by tMCAO was reversed by exercise preconditioning, which also down-regulated the inflammatory cytokines IL-6, CCL11, CCL2, CXCL1, and Fosl1. Conclusions Low-intensity treadmill exercise preconditioning mitigates ischemic stroke injury in mice.
Zeitschrift
Open Access
Translational Exercise Biomedicine
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Editors-in-Chief:
Wilhelm Bloch
Sprache:
Englisch
Erstveröffentlichung:
15. März 2024
Über diese Zeitschrift
Call for Papers: Special Issue "Exercise and Multi-Omics: From Molecules to Health"
Translational Exercise Biomedicine (TEB) is launching a special issue under the banner of "Exercise and Multi-Omics: From Molecules to Health". Recognising the burgeoning application of OMIC techniques in exercise sciences, TEB aims to offer a conduit for publication in terms of mechanistic discovery, diagnostic / prognostic biomarker development, and personalized medicine. For this issue we welcome all types of articles, whether single or multi-OMICS, at the interface of exercise and OMICS. This encompasses genomics / epigenomics, transcriptomics, proteomics, metabolomics, and microbiomics. Manuscripts with a strong translational steer and route to clinical impact are particularly welcome.
Objective
Translational Exercise Biomedicine (TEB) is an international interdisciplinary journal focused on exercise interventions and the underlying mechanisms for improving human health. The journal aims to bridge gaps between knowledge and practice and provide a specific platform for translational research in this field. The editorial board consists of renowned researchers from various countries, facilitating international dissemination and contribution. The journal is owned by Shanghai Jiao Tong University and Guangzhou Sport University. Additionally, TEB is endorsed by the Global Alliance for the Promotion of Physical Activity as the official partner journal.
Aims & scope
Translational Exercise Biomedicine is a peer-reviewed, open access, academic journal, which aims to bridge the gap between mechanistic research and its application to human healt h and clinical practice with a focus on understanding the therapeutic benefits of exercise and improvement of exercise prescription.
Fields of particular interest to the journal include (but are not limited to):
- Integrated exercise physiology, biology, and pathophysiology in health and disease
- Personalized and advanced exercise prescription for health and chronic diseases
- Physical activity/inactivity and health across the lifespan
- Sports medicine and movement science
- Interaction of exercise with diet, nutrition and/or medication
- Exercise and E-health, M-health, AI and technology
Translation means different things in different contexts. As the concept of "exercise is medicine" has grown in recent years, there is an urgent need for translational research in the field of exercise that bridges the gaps between basic scientific discoveries (e.g., detailing the physiological and molecular responses to exercise) and its appli cation to improving human health and targeting specific disease pathophysiology. Translational research is also needed to bridge the gap between clinical trials describing the health benefits of exercise to changes in clinical practice, health promotion and exercise guidelines.
Article types
Original Research Articles, Reviews, Perspectives, Short Communications, Study Protocol
Ihre Vorteile
- Reading cutting-edge/advanced research publications accepted after high-quality peer review
- Open Access for immediate and wide spreading
- Rapid online publication of contributions as "ahead-of-print" versions
- Free of publication charge, infographic, and language checking fee until 2027
Submission
The first issue of Translational Exercise Biomedicine is scheduled to be published online in 2024.
Submissions are open!
You can easily submit your manuscript online. Simply go to http://mc.manuscriptcentral.com/teb and you will be guided through the whole submission and publishing process.
Before preparing a manuscript, please read the journal’s Manuscript Checklist, Instructions for Authors, including the Vancouver reference guide (full | quick) and have a look at our Ethical Guidelines and our License to Publish. Please note that your manuscript may be checked for plagiarism via Crossref Similarity Check.
Your benefits of publishing with us
- Institutionally funded, instant Gold Open Accesss without article processing charges for the authors
- Authors retain copyright – articles published under the Creative Commons Attribution (CC-BY-4.0) License
- Research freely available for all to read and download
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Submission process
- Submission of your manuscript via our submission management tool following the Instructions for Authors
- A decision on whether your paper is eligible for review is aspired within 4 days after submission
- Single-blind peer review process
Accepted articles are produced and published online approx. 4 weeks after acceptance
Please note
- Publication language is English. Manuscripts must be written in clear and concise English
- The Template for Ethical and Legal Declarations is required for submission (needs to be customized by the submitting author on behalf of all others and uploaded as a separate doc-file at the time of the original submission)
- If you have any general questions please visit our FAQ for authors
- For more detailed information please contact the TEB Editorial Office: TEB@sjtu.edu.cn
We are looking forward to receiving your manuscript!
Honorary Editor-in-Chief
Chunhai Fan, Shanghai Jiao Tong University, China
Editors-in-Chief
Wilhelm Bloch, German Sport University Cologne, Germany
Min Hu, Guangzhou Sport University, China
Executive Editor-in-Chief
Sulin Cheng, University of Jyväskylä, Finland
Deputy Editors-in-Chief
Jonathan Little, University of British Columbia, Canada
Yannis Pitsiladis, Hong Kong Baptist University, Hong Kong
Moritz Schumann, Technical University of Munich, Germany
Managing Editor
Shi Zhou, Southern Cross University, Australia
Associate Editors
Julian Alcazar, University of Castilla-La Mancha, Spain
Philip J Atherton, University of Nottingham, UK
Helen Dawes, University of Exeter, Medical School, UK
Albert Gollhofer, University of Freiburg, Germany
Eija Laakkonen, University of Jyväskylä, Finland
Dominik H Pesta, German Aerospace Center, Germany
Willem van Mechelen, Amsterdam University Medical Center, Netherlands
Editorial Board
Eduardo Lusa Cadore, Federal University of Rio Grande do Sul, Brazil
Jeff Coombes, University of Queensland, Australia
Kade Davison, University of South Australia, Australia
Shuzhe Ding, New York University Shanghai, China
Barry A. Franklin , Oakland University William Beaumont School of Medicine, USA
Jorming Goh, National University of Singapore, Singapore
Marcela Gonzalez-Gross , Technical University of Madrid, Spain
Zeguang Han, Shanghai Jiao Tong University, China
Mary Jung, University of British Columbia - Okanagan, Canada
Jari Laukanen, University of Eastern Finland, Finland
Tommy Lundberg, Karolinska Institutet, Sweden
Riku Nikander, University of Jyväskylä, Finland
Vincent Onywera, Kenyatta University, Kenya
Fabio Pigozzi, University of Rome, Italy
Robert Ross, Queen's University, Canada
Arno Schmidt-Trucksäss, University of Basel, Switzerland
Jane Seto, University of Melbourne, Australia
Gareth Stratton, Liverpool John Moores University, UK
LaDora Thompson, Boston University, USA
Chenhong Zhang, Shanghai Jiao Tong University, China
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Weitere Informationen
eISSN:
2942-6812
Sprache:
Englisch
Verlag:
De Gruyter
Weitere Informationen
Erstveröffentlichung:
15. März 2024
