Low-Dose Radiation Suppresses Pokemon Expression under Hypoxic Conditions
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Seung-Whan Kim
Our previous data demonstrated that CoCl2-induced hypoxia controls endoplasmic reticulum (ER) stress-associated and other intracellular factors. One of them, the transcription factor Pokemon, was differentially regulated by low-dose radiation (LDR). There are limited data regarding how this transcription factor is involved in expression of the unfolded protein response (UPR) under hypoxic conditions. The purpose of this study was to obtain clues on how Pokemon is involved in the UPR. Pokemon was selected as a differentially expressed gene under hypoxic conditions; however, its regulation was clearly repressed by LDR. It was also demonstrated that both expression of ER chaperones and ER stress sensors were affected by hypoxic conditions, and the same results were obtained when cells in which Pokemon was up- or down-regulated were used. The current state of UPR and LDR research associated with the Pokemon pathway offers an important opportunity to understand the oncogenesis, senescence, and differentiation of cells, as well as to facilitate introduction of new therapeutic radiopharmaceuticals
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Artikel in diesem Heft
- Anti-Inflammatory Activity of Selected Plants from Saudi Arabia
- Propolis from Northern California and Oregon: Chemical Composition, Botanical Origin, and Content of Allergens
- Synthesis and Pharmacological Evaluation of Novel Unsubstituted Indole-Anthraquinone Carboxamide Derivatives as Potent Antihyperlipidemic Agents
- Anthraquinones from Vismia mexicana
- Vascular and Antioxidant Effects of an Aqueous Mentha cordifolia Extract in Experimental NG-Nitro-L-arginine Methyl Ester-Induced Hypertension
- Bioguided Identification of Antifungal and Antiproliferative Compounds from the Brazilian Orchid Miltonia flavescens Lindl.
- Interspecific Competition between Microcystis aeruginosa and Anabaena flos-aquae from Taihu Lake, China
- Influence of Culture Conditions on the Biotransformation of (+)-Limonene by Aspergillus niger
- Low-Dose Radiation Suppresses Pokemon Expression under Hypoxic Conditions
- Polyamines in Cell Walls of Chlorococcalean Microalgae
- Identification of an Endoplasmic Reticulum Membrane Protein Interacting with DNA Polymerase Beta by a Yeast Two-Hybrid Screen
