Anti-Inflammatory Activity of Selected Plants from Saudi Arabia
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Hossam M. Abdallah
Thirteen selected Saudi Arabian plants, belonging to seven different families, were tested for possible anti-inflammatory activity using the carrageenin-induced paw edema model in rats. The methanolic extracts of Vernonia schimperi, Trichodesma trichodesmoides var. tomentosum, and Anabasis articulata exhibited the highest anti-inflammatory activity. The active extracts were further subjected to fractionation with chloroform, ethyl acetate, and n-butanol and tested together with their mother liquor for their anti-inflammatory activity in the same rat model. The most potent fractions were the n-butanol fractions of Anabasis articulata and Vernonia shimperi and the aqueous mother liquor of Trichodesma trichodesmoides. Nevertheless, the three potent methanolic extracts showed higher anti-inflammatory activities than their individual fractions. The antioxidant properties were assessed by their in vitro 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging activities. It was concluded that the anti-inflammatory activity is dependent, at least in part, on the reduction of prostaglandin (PGE2) and tumour necrosis factor-α (TNF-α) levels and cyclooxygenase-2 (COX-2) activity.
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Artikel in diesem Heft
- Anti-Inflammatory Activity of Selected Plants from Saudi Arabia
- Propolis from Northern California and Oregon: Chemical Composition, Botanical Origin, and Content of Allergens
- Synthesis and Pharmacological Evaluation of Novel Unsubstituted Indole-Anthraquinone Carboxamide Derivatives as Potent Antihyperlipidemic Agents
- Anthraquinones from Vismia mexicana
- Vascular and Antioxidant Effects of an Aqueous Mentha cordifolia Extract in Experimental NG-Nitro-L-arginine Methyl Ester-Induced Hypertension
- Bioguided Identification of Antifungal and Antiproliferative Compounds from the Brazilian Orchid Miltonia flavescens Lindl.
- Interspecific Competition between Microcystis aeruginosa and Anabaena flos-aquae from Taihu Lake, China
- Influence of Culture Conditions on the Biotransformation of (+)-Limonene by Aspergillus niger
- Low-Dose Radiation Suppresses Pokemon Expression under Hypoxic Conditions
- Polyamines in Cell Walls of Chlorococcalean Microalgae
- Identification of an Endoplasmic Reticulum Membrane Protein Interacting with DNA Polymerase Beta by a Yeast Two-Hybrid Screen
