Bioguided Identification of Antifungal and Antiproliferative Compounds from the Brazilian Orchid Miltonia flavescens Lindl.
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Leticia F. Porte
The Orchidaceae family is appreciated worldwide for the beauty of its flowers, and hundreds of species of this family occur in Brazil. Yet little is known about the potential of orchids for therapeutic application. We have investigated bioactive compounds produced by the South Brazilian orchid Miltonia flavescens Lindl. Bioguided studies with the fungus Cladosporium herbarum allowed the identification of hydrocinnamic acid as the active antifungal compound. In addition, the chloroform fraction exhibited an interesting activity against human cancer cells, and 5,7-dihydroxy-6,4'- dimethoxyflavone isolated from this fraction was found to be active against seven human cancer cell lines, including NCI/ADR-RES ovary sarcoma, with an IC50 value of 2.6 mg/mL. This is the first report on the cytostatic activity of this flavone against human ovary sarcoma.
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Articles in the same Issue
- Anti-Inflammatory Activity of Selected Plants from Saudi Arabia
- Propolis from Northern California and Oregon: Chemical Composition, Botanical Origin, and Content of Allergens
- Synthesis and Pharmacological Evaluation of Novel Unsubstituted Indole-Anthraquinone Carboxamide Derivatives as Potent Antihyperlipidemic Agents
- Anthraquinones from Vismia mexicana
- Vascular and Antioxidant Effects of an Aqueous Mentha cordifolia Extract in Experimental NG-Nitro-L-arginine Methyl Ester-Induced Hypertension
- Bioguided Identification of Antifungal and Antiproliferative Compounds from the Brazilian Orchid Miltonia flavescens Lindl.
- Interspecific Competition between Microcystis aeruginosa and Anabaena flos-aquae from Taihu Lake, China
- Influence of Culture Conditions on the Biotransformation of (+)-Limonene by Aspergillus niger
- Low-Dose Radiation Suppresses Pokemon Expression under Hypoxic Conditions
- Polyamines in Cell Walls of Chlorococcalean Microalgae
- Identification of an Endoplasmic Reticulum Membrane Protein Interacting with DNA Polymerase Beta by a Yeast Two-Hybrid Screen
