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Synthesis and study of structural, morphological, optical and toxicological properties of ferromagnetic cobalt oxide nanoparticles in liver carcinoma cell line

Paper presented at the “2nd International Conference on Materials Science and Nanotechnology 2018, MSNANO-18”, 22–23 February 2018, Faisalabad, Pakistan
  • Seemab Iqbal , Muhammad Fakhar-e-Alam , N. Amin , M. Ismail , G. Mustafa , M. Raza Ahmad and M. Atif
Published/Copyright: May 17, 2019
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International Journal of Materials Research
From the journal International Journal of Materials Research Volume 110 Issue 5

Abstract

Cobalt-based nanoparticles are promising candidates towards countless biomedical applications due to their unique characteristics. Co3O4 nanoparticles were synthesized by applying the sol-gel technique and finally sintered at various temperatures (700, 800, 900 °C). The crystal size, morphology, purity, and optical properties were determined using a variety of advanced characterization techniques. To investigate photodynamic therapy feasibility by using Co3O4 nanoparticles in the liver cells, in-vitro cancerous liver cells (HepG2 cells) were exposed to light of wavelength 655 nm (red light) for 30 min at 50 mW cm−2 and in dark as well. After assessment of cell viability analysis, it is concluded that light-induced photodynamic therapy shows significant phototoxic effects based on temperature dependency.

Keywords: Co3O4 nanoparticles; Sol-gel method; Photodynamic therapy
∗Correspondence address, Dr. Muhammad Atif, Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia, E-mail:
∗∗ Dr Muhammad Fakhar-E-Alam, Department of Physics, Govt. College, University, Faisalabad, 38000, Punjab, Pakistan, Tel: +92 331416531, E-mail:

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Received: 2018-04-24
Accepted: 2018-11-10
Published Online: 2019-05-17
Published in Print: 2019-05-15

© 2019, Carl Hanser Verlag, München

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https://doi.org/10.3139/146.111759
Keywords for this article
Co3O4 nanoparticles; Sol-gel method; Photodynamic therapy

Articles in the same Issue

  1. Contents
  2. Contents
  3. Original Contributions
  4. Relationship between the variation in transformation temperatures, resistivity and dislocation density during thermal cycling of Ni50Ti50 shape memory alloy
  5. A critical analysis of the X-ray diffraction intensities in concentrated multicomponent alloys
  6. Thermodynamic investigations in the Al–Fe system: Thermodynamic modeling using CALPHAD
  7. Investigation of semi-solid microstructures of an A356 alloy containing rare-earth Gd during isothermal heat treatment
  8. Effects of double-ageing on the mechanical properties and microstructural evolution in the 1460 alloy
  9. Mechanical properties characterisation of AlSi10Mg parts produced by laser powder bed fusion additive manufacturing
  10. Tribological performance and corrosion behavior of aluminum alloy protected by Cr-doped diamond-like carbon thin film
  11. Effect of sintering temperature on the densification and optical properties of spark plasma sintered ZnSe ceramics
  12. Mono-crystalline SnTe with micro-octahedroncharacteristic: One-pot facile synthesis and comprehensive crystallographic evidence
  13. Finite element simulation of the residual stress in Ti6Al4V titanium alloy laser welded joint
  14. Short Communications
  15. Mechanism of the effect of electron beam melting on the distribution of oxygen, nitrogen and carbon in silicon
  16. Synthesis and study of structural, morphological, optical and toxicological properties of ferromagnetic cobalt oxide nanoparticles in liver carcinoma cell line
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  18. DGM News
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