Developing a multifunctional bio-ceramics composite based on β-tricalcium phosphate working as a single carrier for calcium supplement and low-dose drugs
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Reda Morsy
Abstract
The aim of this work is to develop a multifunctional composite based on β-tricalcium phosphate (β-TCP) working as a single carrier that has a therapeutic function, as a calcium supplement, together with the capability for carrying low-dose drugs. The composite was prepared by blending synthetic β-TCP powder, sodium silicate, and citric acid. The synthetic β-TCP and its composite were characterized using X-ray powder diffraction, Fourier transform infrared spectroscopy, and scanning electron microscopy techniques. Mechanical testing and in-vitro drug release testing, using atenolol, of the fabricated tablets was conducted. The results revealed the synthesis of pure β-TCP powder and fabrication of optimal dense β-TCP-based composite. The β-TCP-based composite exhibited an optimal release behavior of atenolol together with releasing of synthetic β-TCP particles, a calcium supplement.
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© 2016, Carl Hanser Verlag, München
Artikel in diesem Heft
- Contents
- Contents
- Original Contributions
- In-situ annealing and computation study of cube texture development in a commercial aluminum alloy
- Dislocation dynamics modeling of plastic deformation in single-crystal copper at high strain rates
- Investigation of mechanical properties of tubular aluminum foams
- Dependence of microstructure, microhardness, tensile strength and electrical resistivity on growth rates for directionally solidified Zn-Al-Sb eutectic alloy
- Effects of temperature on fatigue limits and fracture morphologies of 40Cr steels formed by warm extrusion
- Synthesis of an oxidation-resistant SiC coating on graphite and modeling analysis with thermodynamics calculations
- Improved corrosion inhibition of 3-amino-1,2,4-triazole on mild steel electrode in HCl solution using surface nanocrystallization
- Chunky graphite formation in ductile cast irons: effect of silicon, carbon and rare earths
- Fabrication of 3D porous MoS2–GO nanocomposite monolith as a promising adsorbent
- Short Communications
- Two-stage method of synthesis of ultrafine powder of α-phase metallic cobalt
- Developing a multifunctional bio-ceramics composite based on β-tricalcium phosphate working as a single carrier for calcium supplement and low-dose drugs
- DGM News
- DGM News
Artikel in diesem Heft
- Contents
- Contents
- Original Contributions
- In-situ annealing and computation study of cube texture development in a commercial aluminum alloy
- Dislocation dynamics modeling of plastic deformation in single-crystal copper at high strain rates
- Investigation of mechanical properties of tubular aluminum foams
- Dependence of microstructure, microhardness, tensile strength and electrical resistivity on growth rates for directionally solidified Zn-Al-Sb eutectic alloy
- Effects of temperature on fatigue limits and fracture morphologies of 40Cr steels formed by warm extrusion
- Synthesis of an oxidation-resistant SiC coating on graphite and modeling analysis with thermodynamics calculations
- Improved corrosion inhibition of 3-amino-1,2,4-triazole on mild steel electrode in HCl solution using surface nanocrystallization
- Chunky graphite formation in ductile cast irons: effect of silicon, carbon and rare earths
- Fabrication of 3D porous MoS2–GO nanocomposite monolith as a promising adsorbent
- Short Communications
- Two-stage method of synthesis of ultrafine powder of α-phase metallic cobalt
- Developing a multifunctional bio-ceramics composite based on β-tricalcium phosphate working as a single carrier for calcium supplement and low-dose drugs
- DGM News
- DGM News
