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Intelligent induction of active biosystem responses at interfaces

  • Daniel Aydin , Vera C. Hirschfeld-Warneken , Ilia Louban und Joachim P. Spatz
Veröffentlicht/Copyright: 11. Juni 2013
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International Journal of Materials Research
Aus der Zeitschrift International Journal of Materials Research Band 102 Heft 7

Abstract

Intelligent interfaces make use of a fundamental molecular understanding of biosystems for the induction of their specific responses. Biological cells especially have an enormous spatial resolution for organizing their transmembrane receptor molecules, which is translated into specific cell functions. In turn, interfaces which provide a counter organization of molecules to required transmembrane receptor organizations are able to induce specific cell responses accordingly. This mission requires a patterning technology at interfaces which operates at the resolution of single molecules. Here, we report on self-assembly technologies for providing such patterns and their subsequent functionalization with cell receptor binding molecules. Cells explore such surfaces and show a very distinct cell response. In the future, such interfaces may “learn” how to induce cell responses properly by analyzing cell responses and providing dynamically the adequate interface pattern which will allow cells to act more successfully in a given, unexpectedly complex environment.

Keywords: Block copolymer nanolithography; Biofunctionalisation; Cell response; Self-assembled nanostructured surfaces; Biomolecule patterning
* Correspondence address Prof. Joachim Spatz Max Planck Institut für Intelligente Systeme (formerly Max Planck Institute for Metals Research) Heisenbergstr. 3, 70569 Stuttgart, Germany Tel.: +49 711 689 3610 Fax: +49 711 689 3612 E-mail:

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Received: 2011-2-2
Accepted: 2011-5-9
Published Online: 2013-06-11
Published in Print: 2011-07-01

© 2011, Carl Hanser Verlag, München

Artikel in diesem Heft

  1. Contents
  2. Contents
  3. Editorial
  4. Max Planck Institute for Metals Research – 90 Years of Excellence in Materials Science
  5. Words of Welcome
  6. Words of Welcome
  7. Feature
  8. Magnetism studied with circularly polarized X-rays
  9. Solid state phase transformation kinetics: Evaluation of the modular transformation model
  10. Intelligent induction of active biosystem responses at interfaces
  11. Empirical Inference
  12. The Stuttgart Center for Electron Microscopy at the Max Planck Institute for Metals Research
  13. The filamentary growth of metals
  14. Kinetics of interface-controlled phase transformations: atomistic and mesoscopic simulations
  15. Breakthroughs in understanding elastic grain interaction and whisker formation made possible by advances in X-ray powder diffraction
  16. Ordered and disordered states in NiAs/Ni2In-type Ni1+δSn: Crystallography and order formation
  17. Of fluctuations and cross-correlations: finding order in disorder
  18. Experimental characterization of tumor spheroids for studies of the energetics of tumor growth
  19. Soft lithography detects partial mechano-sensoric blindness to micrometre topography in cultured aged and diseased cells
  20. The sweet coat of living cells – from supramolecular structure and dynamics to biological function
  21. Nonlinear spectroscopy of bio-interfaces
  22. Dedicated beamlines for in-situ investigations of materials in reduced dimensions
  23. People
  24. Laudationes
  25. Review
  26. Book review
  27. DGM News
  28. DGM News
https://doi.org/10.3139/146.110531
Schlagwörter für diesen Artikel
Block copolymer nanolithography; Biofunctionalisation; Cell response; Self-assembled nanostructured surfaces; Biomolecule patterning

Artikel in diesem Heft

  1. Contents
  2. Contents
  3. Editorial
  4. Max Planck Institute for Metals Research – 90 Years of Excellence in Materials Science
  5. Words of Welcome
  6. Words of Welcome
  7. Feature
  8. Magnetism studied with circularly polarized X-rays
  9. Solid state phase transformation kinetics: Evaluation of the modular transformation model
  10. Intelligent induction of active biosystem responses at interfaces
  11. Empirical Inference
  12. The Stuttgart Center for Electron Microscopy at the Max Planck Institute for Metals Research
  13. The filamentary growth of metals
  14. Kinetics of interface-controlled phase transformations: atomistic and mesoscopic simulations
  15. Breakthroughs in understanding elastic grain interaction and whisker formation made possible by advances in X-ray powder diffraction
  16. Ordered and disordered states in NiAs/Ni2In-type Ni1+δSn: Crystallography and order formation
  17. Of fluctuations and cross-correlations: finding order in disorder
  18. Experimental characterization of tumor spheroids for studies of the energetics of tumor growth
  19. Soft lithography detects partial mechano-sensoric blindness to micrometre topography in cultured aged and diseased cells
  20. The sweet coat of living cells – from supramolecular structure and dynamics to biological function
  21. Nonlinear spectroscopy of bio-interfaces
  22. Dedicated beamlines for in-situ investigations of materials in reduced dimensions
  23. People
  24. Laudationes
  25. Review
  26. Book review
  27. DGM News
  28. DGM News
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