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Biomimetically inspired hybrid materials based on silicified collagen

  • Sascha Heinemann , Hermann Ehrlich , Christiane Knieb und Thomas Hanke
Veröffentlicht/Copyright: 23. Mai 2013
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International Journal of Materials Research
Aus der Zeitschrift International Journal of Materials Research Band 98 Heft 7

Abstract

Starting from a natural example, several hybrid materials based on silicified collagen were synthesised under ambient conditions. The biomimetic approach and further steps allowed the production of porous as well as dense constructs whose structural assembly was similar to that observed microscopically in the natural glass fibres made by sponges. Chemical analyses showed the collagen used serving as an organic template that binds silicic acid whose condensation results in local silicification and strengthening of the hybrid. This effect was emphasised by mechanical testing. Compressive strength of the porous scaffolds has been increased by about four times and splitting tensile strength of the xerogels by up to six times due to hybridisation. As the hybrid materials additionally show proper biocompatibility, they seem to be suitable for medical applications, especially as a base material for load-bearing implants.

Keywords: Hybrid materials; Organic template; Collagen; Silica; Sol-gel
* Correspondence address, Dipl.-Ing. Sascha Heinemann, Dresden University of Technology, Max Bergmann Center of Biomaterials, Biomimetic Materials and Biomaterial Analytics, Budapester Str. 27, D-01069 Dresden, Germany, Tel: +49 351 463 39 381, Fax: +49 351 463 39 401, E-mail:

References

[1] S.Mann: Biomineralization (Oxford University Press, 2002).Suche in Google Scholar

[2] J.Livage, T.Coradin, C.Roux: J. Phys.: Condens. Matter13 (2001) 673.10.1088/0953-8984/13/33/202Suche in Google Scholar

[3] H.Ehrlich, T.Hanke, P.Simon, C.Goebel, S.Heinemann, R.Born, H.Worch: BIOmaterialien6 (2005) 297.10.1515/BIOMAT.2005.6.4.297Suche in Google Scholar

[4] H.Ehrlich, H.Worch, in: E.Bäuerlein (Ed.), Handbook of Biomineralization. Vol. 1. The Biology of Biominerals Structure FormationWILEY VCH, Weinheim (2007).Suche in Google Scholar

[5] H.Ehrlich, H.Worch, C.Eckert, T.Hanke, S.Heinemann, H.Meissner, in: Glasschwammkollagen, Verfahren zu dessen Her-stellung und Verwendung, DE-PA 102005041414 A1 2007.03.01.Suche in Google Scholar

[6] R.Lakes: Nature361 (1993) 511.10.1038/361511a0Suche in Google Scholar

[7] J.O9Kelly, R.Crockett, M.Hogan, P.Calvert: J. Sol-Gel Sci. Technol.8 (1997) 641.Suche in Google Scholar

[8] N.Nassif, O.Bouvet, M.Noelle Rager, C.Roux, T.Coradin, J.Livage: Nat. Mater.1 (2002) 42.10.1038/nmat709Suche in Google Scholar PubMed

[9] M.Muraca, M.T.Vilei, G.E.Zanusso, C.Ferraresso, S.Boninsegna, R.Dal Monte, P.Carraro, G.Carturan: Artif. Organs26 (2002) 664.10.1046/j.1525-1594.2002.06924.xSuche in Google Scholar PubMed

[10] G.Carturan, R.Dal Toso, S.Boninsegna, R.Dal Monte: J. Mater. Chem14 (2004) 2087.10.1039/b401450bSuche in Google Scholar

[11] H.R.Luckarift, J.C.Spain, R.R.Naik, M.O.Stone: Nat. Biotechnol22 (2004) 211.10.1038/nbt931Suche in Google Scholar PubMed

[12] K.J.C.Van Bommel, A.Friggeri, S.Shinkai: Angew. Chem. Int. Ed.42 (2003) 980.10.1002/anie.200390284Suche in Google Scholar PubMed

[13] I.Brasack, U.Hempel, H.Böttcher: J. Sol-Gel Sci. Technol.19 (2000) 479.10.1023/A:1008763900729Suche in Google Scholar

[14] S.V.Patwardhan, S.J.Clarson, C.C.Perry: Chem. Commun. (Camb) (2005) 1113.10.1039/b416926cSuche in Google Scholar PubMed

[15] J.N.Cha, K.Shimizu, Y.Zhou, S.C.Christiansen, B.F.Chmelka, G.D.Stucky, D.E.Morse: Proc. Natl. Acad. Sci. USA96 (1999) 361.10.1073/pnas.96.2.361Suche in Google Scholar

[16] N.Kroger, R.Deutzmann, M.Sumper: Science286 (1999) 1129.10.1126/science.286.5442.1129Suche in Google Scholar

[17] R.R.Naik, M.M.Tomczak, H.R.Luckarift, J.C.Spain, M.O.Stone: Chem. Commun. (Camb) (2004) 1684.10.1039/b404586fSuche in Google Scholar

[18] S.V.Patwardhan, N.Mukherjee, M.Steintz-Kannan, S.J.Clarson: Chem. Commun. (Camb) (2003) 1122.10.1039/b302056hSuche in Google Scholar

[19] D.Eglin, T.Coradin, M.M.Giraud Guille, C.Helary, J.Livage: Biomed. Mater. Eng.15 (2005) 43.Suche in Google Scholar

[20] D.Eglin, K.L.Shafran, J.Livage, T.Coradin, C.C.Perry: J. Mater. Chem.16 (2006) 4220.10.1039/b606270aSuche in Google Scholar

[21] Y.Ono, Y.Kanekiyo, K.Inoue, J.Hojo, M.Nango, S.Shinkai: Chem. Lett.6 (1999) 475.10.1246/cl.1999.475Suche in Google Scholar

[22] H.Ehrlich, S.Heinemann, T.Hanke, H.Worch, in: Hybridmaterialien aus Kollagen und Silikat, Verfahren zu deren Herstellung und Verwendung, DE-PA Nr. 102006040917.5 (2006).Suche in Google Scholar

[23] J.M.Imhoff, R.Garrone: Connect. Tissue Res.11 (1983) 193.10.3109/03008208309004855Suche in Google Scholar

[24] D.Swatschek, W.Schatton, J.Kellermann, W.E.Muller, J.Kreuter: Eur. J. Pharm. Biopharm.53 (2002) 107.10.1016/S0939-6411(01)00192-8Suche in Google Scholar

[25] C.C.Perry, T.Keeling-Tucker: J. Biol. Inorg. Chem.5 (2000) 537.10.1007/s007750000130Suche in Google Scholar

[26] R.Fields: Methods Enzymol.25 (1972) 464.10.1016/S0076-6879(72)25042-XSuche in Google Scholar

[27] T.Coradin, D.Eglin, J.Livage: Spectroscopy18 (2004) 567.10.1155/2004/356207Suche in Google Scholar

[28] M.V.Berridge, A.S.Tan, K.D.McCoy, R.Wang: Biochemica4 (1996) 14.Suche in Google Scholar

[29] T.Coradin, A.Coupe, J.Livage: Colloids Surf. B29 (2003) 189.10.1016/S0927-7765(02)00208-4Suche in Google Scholar

[30] D.Belton, G.Paine, S.V.Patwardhan, C.C.Perry: J. Mater. Chem.14 (2004) 2231.10.1039/b401882fSuche in Google Scholar

[31] D.Eglin, G.Mosser, M.M.Giraud Guille, J.Livage, T.Coradin: Soft Matter1 (2005) 129.10.1039/b503019fSuche in Google Scholar

[32] J.Zhong, D.C.Greenspan: J. Biomed. Mater. Res.53 (2000) 694.10.1002/1097-4636(2000)53:6<694::AID-JBM12>3.0.CO;2-6Suche in Google Scholar

[33] C.C.Perry: Rev. Mineral Geochem.54 (2003) 291.10.2113/0540291Suche in Google Scholar

[34] M.M.Pereira, J.R.Jones, L.L.Hench: Adv. Appl. Ceram.104 (2005) 35.10.1179/174367605225011034Suche in Google Scholar

Received: 2007-2-15
Accepted: 2007-5-14
Published Online: 2013-05-23
Published in Print: 2007-07-01

© 2007, Carl Hanser Verlag, München

Artikel in diesem Heft

  1. Contents
  2. Contents
  3. Editorial
  4. Editorial
  5. Basic
  6. Diffusional decomposition of supersaturated solid solutions at grain boundaries
  7. Characterization of oriented protein-ceramic and protein-polymer-composites for cartilage tissue engineering using synchrotron μ-CT
  8. Effect of ageing on optical and thermal properties of YBa2Cu3O7–δ
  9. Calorimetric study and thermodynamic assessment of the SrO–Ga2O3 system
  10. Re-determination of transition temperatures in the Fe–Al system by differential thermal analysis
  11. Applied
  12. Novel corrosion protective coatings for aluminium alloys and steels based on oxidic nanoparticles
  13. Novel biomimetically based ice-nucleating coatings
  14. Biomimetically inspired hybrid materials based on silicified collagen
  15. Magnesium sponges as a bioabsorbable material – attributes and challenges
  16. Morphology of bony tissues and implants uncovered by high-resolution tomographic imaging
  17. Review
  18. The effects of metal implants on inflammatory and healing processes
  19. Formation of nano hydroxyapatite – a straightforward way to bioactivate bone implant surfaces
  20. Drug-eluting stent technologies for vascular regeneration
  21. Fiber structures for the regenerative medicine
  22. Stimuli-responsive polymer layers for advanced cell culture technologies
  23. Notifications
  24. Robert W. Cahn: 1924–2007
  25. DGM News
https://doi.org/10.3139/146.101519
Schlagwörter für diesen Artikel
Hybrid materials; Organic template; Collagen; Silica; Sol-gel

Artikel in diesem Heft

  1. Contents
  2. Contents
  3. Editorial
  4. Editorial
  5. Basic
  6. Diffusional decomposition of supersaturated solid solutions at grain boundaries
  7. Characterization of oriented protein-ceramic and protein-polymer-composites for cartilage tissue engineering using synchrotron μ-CT
  8. Effect of ageing on optical and thermal properties of YBa2Cu3O7–δ
  9. Calorimetric study and thermodynamic assessment of the SrO–Ga2O3 system
  10. Re-determination of transition temperatures in the Fe–Al system by differential thermal analysis
  11. Applied
  12. Novel corrosion protective coatings for aluminium alloys and steels based on oxidic nanoparticles
  13. Novel biomimetically based ice-nucleating coatings
  14. Biomimetically inspired hybrid materials based on silicified collagen
  15. Magnesium sponges as a bioabsorbable material – attributes and challenges
  16. Morphology of bony tissues and implants uncovered by high-resolution tomographic imaging
  17. Review
  18. The effects of metal implants on inflammatory and healing processes
  19. Formation of nano hydroxyapatite – a straightforward way to bioactivate bone implant surfaces
  20. Drug-eluting stent technologies for vascular regeneration
  21. Fiber structures for the regenerative medicine
  22. Stimuli-responsive polymer layers for advanced cell culture technologies
  23. Notifications
  24. Robert W. Cahn: 1924–2007
  25. DGM News
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