Synthesis of new aryl(hetaryl)-substituted tandospirone analogues with potential anxiolytic activity via reductive Heck type hydroarylations
Abstract
Tandospirone (I), developed as an anxiolytic drug, is an aryl-piperazine compound that binds to both 5-HT1A and dopamine D4 receptors. Palladium-catalysed hydroarylation reactions of tandospirone analogues containing an oxygen bridge and 3-(trifluoromethyl)phenyl or 2,3-dichlorophenyl groups were studied in order to find a new stereoselective access to a series of new exo-aryl(hetaryl)-substituted derivatives with potential biological activity.
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© 2013 Institute of Chemistry, Slovak Academy of Sciences
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Artikel in diesem Heft
- Enzymatic synthesis of kojic acid esters and their potential industrial applications
- KI-catalysed synthesis of 4-methylcatechol dimethylacetate and fragrant compound Calone 1951®
- Sequestration of supercritical CO2 by mercury oxide
- Assessment of the fate of some household micropollutants in urban wastewater treatment plant
- Synthesis in water-free DMF, characterization, electrical, and gas sensing properties of bis[2-(2-aminoethylamino)ethanol]copper(II) dibromide
- Mechanism of α-acetyl-γ-butyrolactone synthesis
- Spirocyclisation of phytoalexin 1-methoxybrassinin in the presence of Grignard reagents
- Synthesis of new aryl(hetaryl)-substituted tandospirone analogues with potential anxiolytic activity via reductive Heck type hydroarylations
- Methyl-2-arylidene hydrazinecarbodithioates: synthesis and biological activity
- Degradation products of proguanil — 4-chloroaniline and related components with regard to genotoxicity
- In situ bioconversion of compactin to pravastatin by Actinomadura species in fermentation broth of Penicillium citrinum
- Mineral element content in prized matsutake mushroom (Tricholoma matsutake) collected in China