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Metabolomic approach to Alzheimer’s disease diagnosis based on mass spectrometry

  • Raúl González-Domínguez EMAIL logo , Tamara García-Barrera and José-Luis Gómez-Ariza
Published/Copyright: June 22, 2012
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Abstract

Alzheimer’s disease is the most common neurodegenerative disease, but there is still no cure and early diagnosis remains very difficult. For this reason, the discovery of new biomarkers is of great importance. The application of metabolomics is emerging in this field, based on the use of mass spectrometry as a technique of analysis. In this work, blood serum samples (from Alzheimer’s disease patients and healthy controls) were analysed by mass spectrometry in order to search for potential metabolomic biomarkers. The application of multivariate statistical tools (PLS-DA) enabled us to discriminate between groups. In addition, some phosphatidylcholine compounds were identified as markers of the disease.

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Published Online: 2012-6-22
Published in Print: 2012-9-1

© 2012 Institute of Chemistry, Slovak Academy of Sciences

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