Abstract
Hybrid processes have received increased attention in the field of chemical and biochemical engineering because of their ability to overcome certain obstacles related to thermodynamics of the separation task to be carried out. Usually, in a hybrid process two processes are coupled; either reaction with separation or two different separation processes. In the design of such hybrid systems, the performance of each constituent element has to be taken into account, while their optimisation must account for their interdependency. In this paper, the methodology presented by Mitkowski et al. (2009a) is applied to design and analyse a hybrid process scheme for the synthesis of ethyl lactate. Generated hybrid process schemes have been validated through computer-aided simulations.
[1] Adams, T. A., II, & Seider, W. D. (2008). Semicontinuous distillation for ethyl lactate production. AIChE Journal, 54, 2539–2552. DOI: 10.1002/aic.11585. http://dx.doi.org/10.1002/aic.1158510.1002/aic.11585Search in Google Scholar
[2] Benedict, D. J., Parulekar, S. J., & Tsai, S. P. (2006). Pervaporation-assisted esterification of lactic and succinic acids with downstream ester recovery. Journal of Membrane Science, 281, 435–445. DOI: 10.1016/j.memsci.2006.04.012. http://dx.doi.org/10.1016/j.memsci.2006.04.01210.1016/j.memsci.2006.04.012Search in Google Scholar
[3] Benedict, D. J., Parulekar, S. J., & Tsai, S.-P. (2003). Esterification of lactic acid and ethanol with/without pervaporation. Industrial & Engineering Chemistry Research, 42, 2282–2291. DOI: 10.1021/ie020850i. http://dx.doi.org/10.1021/ie020850i10.1021/ie020850iSearch in Google Scholar
[4] Blahušiak, M., Schlosser, Š., & Marták, J. (2010). Simulation of a hybrid fermentation-separation process for production of butyric acid. Chemical Papers, 64, 213–222. DOI: 10.2478/s11696-009-0114-7. http://dx.doi.org/10.2478/s11696-009-0114-710.2478/s11696-009-0114-7Search in Google Scholar
[5] Buchaly, C., Kreis, P., & Górak, A. (2007). Hybrid separation processes-Combination of reactive distillation with membrane separation. Chemical Engineering and Processing, 46, 790–799. DOI: 10.1016/j.cep.2007.05.023. http://dx.doi.org/10.1016/j.cep.2007.05.02310.1016/j.cep.2007.05.023Search in Google Scholar
[6] CAPEC (Computer Aided Process Engineering Center) (2008). Integrated computer aided system (ICAS) (Manual delivered with ICAS software). Lyngby, Denmark: Technical University of Denmark. Search in Google Scholar
[7] CAPEC (Computer Aided Process Engineering Center) (2002). ICAS documentations. Lyngby, Denmark: Technical University of Denmark. (CAPEC Internal Report, PEC02-14). Search in Google Scholar
[8] Delgado, P., Sanz, M. T., & Beltrán, S. (2007a). Isobaric vapour-liquid equilibria for the quaternary reactive system: Ethanol + water + ethyl lactate + lactic acid at 101.33 kPa. Fluid Phase Equilibria, 255, 17–23. DOI: 10.1016/j.fluid.2007.03.022. http://dx.doi.org/10.1016/j.fluid.2007.03.02210.1016/j.fluid.2007.03.022Search in Google Scholar
[9] Delgado, P., Sanz, M. T., & Beltrán, S. (2007b). Kinetic study for esterification of lactic acid with ethanol and hydrolysis of ethyl lactate using an ion-exchange resin catalyst. Chemical Engineering Journal, 126, 111–118. DOI: 10.1016/j.cej.2006.09.004. http://dx.doi.org/10.1016/j.cej.2006.09.00410.1016/j.cej.2006.09.004Search in Google Scholar
[10] Engin, A., Haluk, H., & Gurkan, K. (2003). Production of lactic acid esters catalyzed by heteropoly acid supported over ion-exchange resins. Green Chemistry, 5, 460–466. DOI: 10.1039/b303327a. http://dx.doi.org/10.1039/b303327a10.1039/b303327aSearch in Google Scholar
[11] Gani, R., Hytoft, G., Jaksland, C., & Jensen, A. K. (1997). An integrated computer aided system for integrated design of chemical processes. Computers & Chemical Engineering, 21, 1135–1146. DOI: 10.1016/S0098-1354(96)00324-9. http://dx.doi.org/10.1016/S0098-1354(96)00324-910.1016/S0098-1354(96)00324-9Search in Google Scholar
[12] Gani, R., Jiménez-González, C., & Constable, D. J. C. (2005). Method for selection of solvents for promotion of organic reactions. Computers & Chemical Engineering, 29, 1661–1676. DOI: 10.1016/j.compchemeng.2005.02.021. http://dx.doi.org/10.1016/j.compchemeng.2005.02.02110.1016/j.compchemeng.2005.02.021Search in Google Scholar
[13] Gani, R., & O’Connell, J. P. (1989). A knowledge based system for the selection of thermodynamic models. Computers & Chemical Engineering, 13, 397–404. DOI: 10.1016/0098-1354(89)85019-7. http://dx.doi.org/10.1016/0098-1354(89)85019-710.1016/0098-1354(89)85019-7Search in Google Scholar
[14] Koszorz, Z., Nemestothy, N., Ziobrowski, Z., Belafi-Bako, K., & Krupiczka, R. (2004). Influence of pervaporation process parameters on enzymatic catalyst deactivation. Desalination, 162, 307–313. DOI: 10.1016/S0011-9164(04)00064-5. http://dx.doi.org/10.1016/S0011-9164(04)00064-510.1016/S0011-9164(04)00064-5Search in Google Scholar
[15] Lipnizki, F., Field, R. W., & Ten, P.-K, (1999). Pervaporation-based hybrid process: a review of process design, applications and economics. Journal of Membrane Science, 153, 183–210. DOI: 10.1016/S0376-7388(98)00253-1. http://dx.doi.org/10.1016/S0376-7388(98)00253-110.1016/S0376-7388(98)00253-1Search in Google Scholar
[16] Matouq, M., Tagawa, T., & Goto, S. (1994). Combined process for production of methyl tert-buthyl ether from tert-buthyl alcohol and methanol. Journal of Chemical Engineering of Japan, 27, 302–306. DOI: 10.1252/jcej.27.302. http://dx.doi.org/10.1252/jcej.27.30210.1252/jcej.27.302Search in Google Scholar
[17] Mihaľ, M., Švandovǎ, Z., & Markoš, J. (2010). Steady state and dynamic simulation of a hybrid reactive separation process. Chemical Papers, 64, 193–202. DOI: 10.2478/s11696-009-0110-y. http://dx.doi.org/10.2478/s11696-009-0110-y10.2478/s11696-009-0110-ySearch in Google Scholar
[18] Mitkowski, P. T., Buchaly, C., Kreis, P., Jonsson, G., Górak, A., & Gani, R. (2009a). Computer aided design, analysis and experimental investigation of membrane assisted batch reaction-separation systems. Computers & Chemical Engineering, 33, 551–574. DOI: 10.1016/j.compchemeng.2008.07. 012. http://dx.doi.org/10.1016/j.compchemeng.2008.07.01210.1016/j.compchemeng.2008.07.012Search in Google Scholar
[19] Mitkowski, P. T., Gani, R., & Broniarz-Press, L. (2009b). Novel membrane database in chemical process design. In Proceedings of the 8th World Congress of Chemical Engineering, 23–27 August 2009 (Paper No. 687, pp. 1–6). Montreal, QC, Canada. Search in Google Scholar
[20] Mulder, M., (1996). Basic principles of membrane technology (2nd ed.). Dordrecht, The Netherlands: Kluwer Academic. 10.1007/978-94-009-1766-8Search in Google Scholar
[21] Nielsen, T. L., Abildskov, J., Harper, P. M., Papaeconomou, I., & Gani, R. (2001). The CAPEC database. Journal of Chemical & Engineering Data, 46, 1041–1044. DOI: 10.1021/je000244z. http://dx.doi.org/10.1021/je000244z10.1021/je000244zSearch in Google Scholar
[22] Parulekar, S. J. (2007). Analysis of pervaporation-aided esterification of organic acids. Industrial & Engineering Chemistry Research, 46, 8490–8504. DOI: 10.1021/ie061157o. http://dx.doi.org/10.1021/ie061157o10.1021/ie061157oSearch in Google Scholar
[23] Pérez Cisneros, E. S., Gani, R., & Michelsen, M. L. (1997). Reactive separation systems—I. Computation of physical and chemical equilibrium. Chemical Engineering Science, 52, 527–543. DOI: 10.1016/S0009-2509(96)00424-1. http://dx.doi.org/10.1016/S0009-2509(96)00424-110.1016/S0009-2509(96)00424-1Search in Google Scholar
[24] Sales-Cruz, M., & Gani, R. (2003). A modelling tool for different stages of the process life. In S. P. Asprey, & S. Macchietto (Eds.), Computer aided chemical engineering (Vol. 16, pp. 209–249). Amsterdam, The Netherlands: Elsevier. DOI: 10.1016/S1570-7946(03)80076-7. 10.1016/S1570-7946(03)80076-7Search in Google Scholar
[25] Schmidt-Traub, H., & Górak, A. (2006). Integrated reaction and separation operations: Modelling and experimental operations. Berlin, Heidelberg, Germany: Springer-Verlag. Search in Google Scholar
[26] Sigma-Aldrich (2010). Product catalog. Retrieved March 11, 2011, from www.sigmaaldrich.com Search in Google Scholar
[27] Van Baelen, D., Van der Bruggen, B., Van den Dungen, K., Degreve, J., & Vandecasteele, C. (2005). Pervaporation of water-alcohol mixtures and acetic acid-water mixtures. Chemical Engineering Science, 60, 1583–1590. DOI: 10.1016/j.ces.2004.10.030. http://dx.doi.org/10.1016/j.ces.2004.10.03010.1016/j.ces.2004.10.030Search in Google Scholar
[28] Vu, D. T., Lira, C. T., Asthana, N. S., Kolah, A. K., & Miller, D. J. (2006). Vapor-liquid equilibria in the systems ethyl lactate + ethanol and ethyl lactate + water. Journal of Chemical & Engineering Data, 51, 1220–1225. DOI: 10.1021/je050537y. http://dx.doi.org/10.1021/je050537y10.1021/je050537ySearch in Google Scholar
[29] Whu, J. A., Baltzis, B. C., & Sirkar, K. K. (1999). Modelling of nanofiltration — assisted organic synthesis. Journal of Membrane Science, 163, 319–331. DOI: 10.1016/S0376-7388(99)00175-1. http://dx.doi.org/10.1016/S0376-7388(99)00175-110.1016/S0376-7388(99)00175-1Search in Google Scholar
[30] Zhang, Y., Ma, L., & Yang, J. (2004). Kinetics of esterification of lactic acid with ethanol catalyzed by cation-exchange resins. Reactive and Functional Polymers, 61, 101–114, DOI: 10.1016/j.reactfunctpolym.2004.04.003. http://dx.doi.org/10.1016/j.reactfunctpolym.2004.04.00310.1016/j.reactfunctpolym.2004.04.003Search in Google Scholar
© 2011 Institute of Chemistry, Slovak Academy of Sciences
Articles in the same Issue
- Lipid retention of novel pressurized extraction vessels as a function of the number of static and flushing cycles, flush volume, and flow rate
- Determination of curcuminoids in substances and dosage forms by cyclodextrin-mediated capillary electrophoresis with diode array detection
- Interaction of Moringa oleifera seed lectin with humic acid
- Hybrid process scheme for the synthesis of ethyl lactate: conceptual design and analysis
- Zinc catalyst recycling in the preparation of (all-rac)-α-tocopherol from trimethylhydroquinone and isophytol
- Denitrification of simulated nitrate-rich wastewater using sulfamic acid and zinc scrap
- Anaerobic treatment of biodiesel by-products in a pilot scale reactor
- Preparation of magnesium hydroxide from nitrate aqueous solution
- Impact of the type of anodic film formed and deposition time on the characteristics of porous anodic aluminium oxide films containing Ni metal
- Synthesis and crystal and molecular structures of N,N′-methylenedipyridinium tetrachlorozincate(II) and N,N′-methylenedipyridinium tetrachlorocadmate(II)
- Effects of denaturing acid on the self-association behaviour of poly(ethylene glycol)-block-poly(γ-benzyl l-glutamate)-graft-poly(ethylene glycol) copolymer in ethanol
- Properties of poly(γ-benzyl l-glutamate) membrane modified by polyurethane containing carboxyl group
- Theoretical thermo-optical patterns relevant to glass crystallisation
- Morphology dependence of 1,2-diphenylethylenediamine-derived organogelator templates in solvents and their influence in the production of nanostructured silica
- Ferric hydrogensulphate as a recyclable catalyst for the synthesis of fluorescein derivatives
- An alternative synthetic process of p-acetaminobenzenesulfonyl chloride through combined chlorosulfonation by HClSO3 and PCl5
- An efficient and novel one-pot synthesis of 2,4,5-triaryl-1H-imidazoles catalyzed by UO2(NO3)2·6H2O under heterogeneous conditions
- Stereoselective synthesis of the polar part of mycestericins E and G
- A regio- and stereoselective three-component synthesis of 5-(trifluoromethyl)-4,5,6,7-tetrahydro-[1,2,4]triazolo[1,5-a]pyrimidine derivatives under solvent-free conditions
- Precautions in using global kinetic and thermodynamic models for characterization of drug release from multivalent supports
- A sandwich anion receptor by a BODIPY dye bearing two calix[4]pyrrole units
- What causes iron-sulphur bonds in active sites of one-iron superoxide reductase and two-iron superoxide reductase to differ?
- MTD-PLS and docking study for a series of substituted 2-phenylindole derivatives with oestrogenic activity
Articles in the same Issue
- Lipid retention of novel pressurized extraction vessels as a function of the number of static and flushing cycles, flush volume, and flow rate
- Determination of curcuminoids in substances and dosage forms by cyclodextrin-mediated capillary electrophoresis with diode array detection
- Interaction of Moringa oleifera seed lectin with humic acid
- Hybrid process scheme for the synthesis of ethyl lactate: conceptual design and analysis
- Zinc catalyst recycling in the preparation of (all-rac)-α-tocopherol from trimethylhydroquinone and isophytol
- Denitrification of simulated nitrate-rich wastewater using sulfamic acid and zinc scrap
- Anaerobic treatment of biodiesel by-products in a pilot scale reactor
- Preparation of magnesium hydroxide from nitrate aqueous solution
- Impact of the type of anodic film formed and deposition time on the characteristics of porous anodic aluminium oxide films containing Ni metal
- Synthesis and crystal and molecular structures of N,N′-methylenedipyridinium tetrachlorozincate(II) and N,N′-methylenedipyridinium tetrachlorocadmate(II)
- Effects of denaturing acid on the self-association behaviour of poly(ethylene glycol)-block-poly(γ-benzyl l-glutamate)-graft-poly(ethylene glycol) copolymer in ethanol
- Properties of poly(γ-benzyl l-glutamate) membrane modified by polyurethane containing carboxyl group
- Theoretical thermo-optical patterns relevant to glass crystallisation
- Morphology dependence of 1,2-diphenylethylenediamine-derived organogelator templates in solvents and their influence in the production of nanostructured silica
- Ferric hydrogensulphate as a recyclable catalyst for the synthesis of fluorescein derivatives
- An alternative synthetic process of p-acetaminobenzenesulfonyl chloride through combined chlorosulfonation by HClSO3 and PCl5
- An efficient and novel one-pot synthesis of 2,4,5-triaryl-1H-imidazoles catalyzed by UO2(NO3)2·6H2O under heterogeneous conditions
- Stereoselective synthesis of the polar part of mycestericins E and G
- A regio- and stereoselective three-component synthesis of 5-(trifluoromethyl)-4,5,6,7-tetrahydro-[1,2,4]triazolo[1,5-a]pyrimidine derivatives under solvent-free conditions
- Precautions in using global kinetic and thermodynamic models for characterization of drug release from multivalent supports
- A sandwich anion receptor by a BODIPY dye bearing two calix[4]pyrrole units
- What causes iron-sulphur bonds in active sites of one-iron superoxide reductase and two-iron superoxide reductase to differ?
- MTD-PLS and docking study for a series of substituted 2-phenylindole derivatives with oestrogenic activity