Determination of norfloxacin in pharmaceuticals, human serum, and urine using a luminol—dissolved oxygen chemiluminescence system
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X. Shao
,
H. Liu
Abstract
A sensitive chemiluminescence method, based on the enhancive effect of norfloxacin on the reaction between luminol and dissolved oxygen in a flow injection system, was proposed for the determination of norfloxacin. The increment of the chemiluminiscence intensity was proportional to the concentration of norfloxacin, giving a calibration graph linear over the concentration from 0.4 ng mL−1 to 400.0 ng mL−1 (r 2 = 0.9988) with the detection limit of 0.1 ng mL−1 (3 × σ noise). At the flow rate of 2.0 mL min−1, a complete determination of norfloxacin, including sampling and washing, could be accomplished in 30 s with the relative standard deviation lower than 3.0 %. The proposed method was applied successfully to determine norfloxacin in pharmaceuticals, human urine, and serum. Possible mechanism of the reaction was also discussed.
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© 2007 Institute of Chemistry, Slovak Academy of Sciences
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Artikel in diesem Heft
- Determination of potassium in fatty acid methyl esters applying an ion-selective potassium electrode
- Selective solid-phase extraction of Cu(II) using freshly precipitated lead diethyldithiocarbamate and its spectrophotometric determination
- Evaluation of colon cancer elements contents in serum using statistical methods
- Determination of norfloxacin in pharmaceuticals, human serum, and urine using a luminol—dissolved oxygen chemiluminescence system
- Properties of fructosyltransferase from Aureobasidium pullulans immobilized on an acrylic carrier
- Influence of two-phase system composition on biocatalytic properties of β-galactosidase preparations
- Thermal decomposition kinetics of strontium oxalate
- Synthesis and properties of lanthanide(III) complexes with 4-hydroxy-3,5-dimethoxybenzoic acid
- Influence of photoinitiator and curing conditions on polymerization kinetics and gloss of UV-cured coatings
- Interactions in iron gall inks
- Bimolecular reduction of 9-alkyl-3-nitrocarbazoles
- A detailed analysis of volatile constituents of Aquilegia pancicii Degen, a Serbian steno-endemic species
- A one-pot synthesis of 8-amino-1-methoxy-6H-dibenzo[b,d]pyran-6-one
- Magnetically modified bentonite as a possible contrast agent in MRI of gastrointestinal tract
