An adapted purification procedure to improve the quality of 90Y for clinical use
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Abmel Xiques Castillo
Abstract
There is an increasing interest for 90Y for radionuclide therapy. However, radioimmunotherapy, one of the most important applications for 90Y, demands a very high purity product. Obtaining a high quality 90Y is difficult not only because of the complex and time consuming production schemes but also because of the quality control which has challenging tasks like the determination of 90Sr at very low concentrations. The present paper investigates a reported purification procedure for the removal of stable metal trace contaminants from an 90Y solution, seeking for its potential use in the elimination of the radioactive contaminant 90Sr and its fast determination. For this purpose a washing step with HNO3 acid is introduced to elute 90Sr, the order of each acid solution is rearranged to reduce the potential contaminants present in acids and the size of the column is reduced to further optimize the procedure. As a result, an improved purification method is obtained, which allows the removal of both trace metal contaminants and 90Sr from an 90Y solution and the measurement of 90Sr/90Y ratios of the order of 10-7, which are well below the established pharmacopeia limit of 2×10-5.
© by Oldenbourg Wissenschaftsverlag, München, Germany
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Artikel in diesem Heft
- Production and separation of no-carrier-added 93,94,95Tc from 9Be activated yttrium target
- Charged particle induced reaction cross section data for production of the emerging medically important positron emitter 64Cu: A comprehensive evaluation
- Determination of 126Sn half-life from ICP-MS and gamma spectrometry measurements
- Investigation of K to L shell/subshell vacancy transitions of Zn and Fe in FexZn1-x thin film alloys
- X-ray absorption spectroscopic study of trivalent and tetravalent actinides in solution at varying pH values
- Kinetic and thermodynamic studies on the adsorption of U(VI) ions on densely crosslinked poly(methacrylic acid) from aqueous solutions
- Extraction of americium(III) from nitric acid medium by CMPO-TBP extractants in ionic liquid diluent
- Uranium, plutonium and neptunium co-recovery with high nitric acid concentration in extraction section by simplified solvent extraction process
- Separation of 109Cd from silver targets by nanohematite
- An adapted purification procedure to improve the quality of 90Y for clinical use
- Novel polymer vectors of 64Cu
- Radiosynthesis of a novel potential adenosine A3 receptor ligand, 5-ethyl 2,4-diethyl-3-((2-[18F]fluoroethyl)sulfanylcarbonyl)-6-phenylpyridine-5-carboxylate ([18F]FE@SUPPY:2)
- Determination of solubility parameters of cobalt(II) and indium(III) oxinates by tracer technique
- Evaluation of trace elements in chewing tobacco and snuff using instrumental neutron activation analysis (INAA) and atomic absorption spectroscopy (AAS)
