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Novel polymer vectors of 64Cu
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J. Kozempel
Published/Copyright:
December 4, 2009
Abstract
We describe a preparation of novel polymer vectors of 64Cu based on co-polymers of poly- (N-isopropylacrylamide) and poly- (N-hydroxypropylmethacrylamide). DOTA, DTPA, dipicolylamine, thiosemicarbazone and Ag-ionophore-II ligands were tested to bind 64Cu in a polymer chain. Labeling yields with no-carrier-added 64Cu varied from 95 to 99% in 30 min. at laboratory temperature. Vectors were stable in vitro for 24 h in human serum and might be prospective for targeted 64Cu radio or combined radiochemotherapy.
Published Online: 2009-12-04
Published in Print: 2009-12
© by Oldenbourg Wissenschaftsverlag, München, Germany
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- Charged particle induced reaction cross section data for production of the emerging medically important positron emitter 64Cu: A comprehensive evaluation
- Determination of 126Sn half-life from ICP-MS and gamma spectrometry measurements
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- X-ray absorption spectroscopic study of trivalent and tetravalent actinides in solution at varying pH values
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- Extraction of americium(III) from nitric acid medium by CMPO-TBP extractants in ionic liquid diluent
- Uranium, plutonium and neptunium co-recovery with high nitric acid concentration in extraction section by simplified solvent extraction process
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- An adapted purification procedure to improve the quality of 90Y for clinical use
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- Radiosynthesis of a novel potential adenosine A3 receptor ligand, 5-ethyl 2,4-diethyl-3-((2-[18F]fluoroethyl)sulfanylcarbonyl)-6-phenylpyridine-5-carboxylate ([18F]FE@SUPPY:2)
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