Concentration of 99mTc-pertechnetate and 188Re-perrhenate
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M. S. Mansur
Summary
The radioactive concentrations of 99mTc/188Re from their generators are dependent upon the specific activity of 99Mo/188W, which dictates the bed size of the alumina/gel column and the volume of physiological saline needed as eluent. Because of the high content of inactive molybdenum/tungsten in neutron irradiated MoO3/WO3, large columns containing alumina/gel are needed to produce chromatographic 99Mo → 99mTc/188W → 188Re generators. This results in large elution volumes containing relatively high 99Mo/188W contents and low concentrations of 99mTc/188Re. The decrease in radioactive concentration, or specific volume, places a limitation on some of the clinical procedures. We report post elution concentration of 99mTc/188Re using in house prepared silver cation exchange and alumina column. The high bolus volumes (10 − 60 ml saline) can conveniently be concentrated in 1 ml of saline. This approach also works very effectively to yield high specific volume solutions of 99mTc-pertechnetate from a fission 99Mo loaded alumina generator towards the end of its normal working life.
© Oldenbourg Wissenschaftsverlag, München
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Articles in the same Issue
- Measurement of fission neutron spectrum averaged cross sections of some threshold reactions on zinc: small-scale production of no-carrier-added 64Cu in a nuclear reactor
- Interaction of neptunium(V) with picolinic, nicotinic and isonicotinic acids
- Soil-to-fungi transfer of 90Sr, 239+240Pu, and 241Am
- Thermodynamic study of metal silicate complexation in perchlorate media
- Sorption of radionuclides from complexone solutions in liquid CO2
- Photochemical behaviour of Tc2OCl104– and TcnOy4n–2y+ in chloride media
- Effect of pH and fulvic acid on sorption and complexation of cobalt onto bare and FA bound MX-80 bentonite
- Inhibiting radiolysis of BTP molecules by addition of nitrobenzene
- Concentration of 99mTc-pertechnetate and 188Re-perrhenate
- Preparation of [61Cu]pyruvaldehyde-bis (N4-methylthiosemicarbazone) complex as a possible PET radiopharmaceutical
- Syntheses of two potential dopamine D4 receptor radioligands: 18F labelled chromeno[3,4-c]pyridin-5-ones
