Syntheses of two potential dopamine D4 receptor radioligands: 18F labelled chromeno[3,4-c]pyridin-5-ones
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Gu-Cai Li
Summary
The dopamine D4 receptor is hypothesized to relate with the pathophysiology and pharmacotherapy of schizophrenia while its level in brain regions is much lower and to date no suitable tracer is available for the study of D4 receptor in vivo . Therefore, selective imaging agents for the D4 subtype are badly needed. Based on the structure-activity analysis of chromeno[3,4-c]pyridin-5-ones as dopamine D4 receptor ligands, two fluorine-18 labelled chromeno[3,4-c] pyridin-5-one derivatives, 3-(4-[18F]fluorobenzyl)-8-hydroxy-1,2,3,4-tetrahydrochromeno[3,4-c]pyridin-5-one and 3-(4-[18F]fluorobenzyl)-8,9-dimethoxy-1,2,3,4-tetrahydrochromeno[3,4-c]pyridin-5-one were synthesized through a two-step one-pot method. Their radiochemical yields were around 19.7% (decay-corrected) and radiochemical purities were higher than 95% with specific activities of about 120 GBq/μmol.
© Oldenbourg Wissenschaftsverlag, München
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Articles in the same Issue
- Measurement of fission neutron spectrum averaged cross sections of some threshold reactions on zinc: small-scale production of no-carrier-added 64Cu in a nuclear reactor
- Interaction of neptunium(V) with picolinic, nicotinic and isonicotinic acids
- Soil-to-fungi transfer of 90Sr, 239+240Pu, and 241Am
- Thermodynamic study of metal silicate complexation in perchlorate media
- Sorption of radionuclides from complexone solutions in liquid CO2
- Photochemical behaviour of Tc2OCl104– and TcnOy4n–2y+ in chloride media
- Effect of pH and fulvic acid on sorption and complexation of cobalt onto bare and FA bound MX-80 bentonite
- Inhibiting radiolysis of BTP molecules by addition of nitrobenzene
- Concentration of 99mTc-pertechnetate and 188Re-perrhenate
- Preparation of [61Cu]pyruvaldehyde-bis (N4-methylthiosemicarbazone) complex as a possible PET radiopharmaceutical
- Syntheses of two potential dopamine D4 receptor radioligands: 18F labelled chromeno[3,4-c]pyridin-5-ones
