Preparation of [61Cu]pyruvaldehyde-bis (N4-methylthiosemicarbazone) complex as a possible PET radiopharmaceutical
-
A.R. Jalilian
Summary
Copper-61 (T1/2= 3.33 h) produced via the natZn(p,x) 61Cu nuclear reaction using natural zinc target, was separated from the irradiated target material by a two-step method developed in our laboratory and was used for the preparation of [61Cu]-pyruvaldehyde- bis (N4-methylthiosemicarbazone) ([61Cu]-PTSM) using an in house-made PTSM ligand. An electroplated natural zinc layer on a gold-coated copper backing (zinc and gold layer thicknesses were 80 and 50 μm respectively) was irradiated with 22 MeV; protons (22−12 MeV; on the target). 61Cu was separated by a two-step chromatography method using a cation and an anion exchange column which gave satisfactory results. After 180 μA irradiation of the target for 3.2 hours, about 6.006 Ci of 61Cu2+ was obtained with a radiochemical separation yield of more than 95% and a radionuclidic purity of more than 99% (60Cu as impurity). Colorimetric methods showed that traces of chemical impurities in the product were below the accepted limits. The solution of [61Cu]-PTSM was prepared with a radiochemical yield of higher than 80%, radiochemical purity of better than 98% and specific activity of about 246 Ci/mmol.
© Oldenbourg Wissenschaftsverlag, München
Articles in the same Issue
- Measurement of fission neutron spectrum averaged cross sections of some threshold reactions on zinc: small-scale production of no-carrier-added 64Cu in a nuclear reactor
- Interaction of neptunium(V) with picolinic, nicotinic and isonicotinic acids
- Soil-to-fungi transfer of 90Sr, 239+240Pu, and 241Am
- Thermodynamic study of metal silicate complexation in perchlorate media
- Sorption of radionuclides from complexone solutions in liquid CO2
- Photochemical behaviour of Tc2OCl104– and TcnOy4n–2y+ in chloride media
- Effect of pH and fulvic acid on sorption and complexation of cobalt onto bare and FA bound MX-80 bentonite
- Inhibiting radiolysis of BTP molecules by addition of nitrobenzene
- Concentration of 99mTc-pertechnetate and 188Re-perrhenate
- Preparation of [61Cu]pyruvaldehyde-bis (N4-methylthiosemicarbazone) complex as a possible PET radiopharmaceutical
- Syntheses of two potential dopamine D4 receptor radioligands: 18F labelled chromeno[3,4-c]pyridin-5-ones
Articles in the same Issue
- Measurement of fission neutron spectrum averaged cross sections of some threshold reactions on zinc: small-scale production of no-carrier-added 64Cu in a nuclear reactor
- Interaction of neptunium(V) with picolinic, nicotinic and isonicotinic acids
- Soil-to-fungi transfer of 90Sr, 239+240Pu, and 241Am
- Thermodynamic study of metal silicate complexation in perchlorate media
- Sorption of radionuclides from complexone solutions in liquid CO2
- Photochemical behaviour of Tc2OCl104– and TcnOy4n–2y+ in chloride media
- Effect of pH and fulvic acid on sorption and complexation of cobalt onto bare and FA bound MX-80 bentonite
- Inhibiting radiolysis of BTP molecules by addition of nitrobenzene
- Concentration of 99mTc-pertechnetate and 188Re-perrhenate
- Preparation of [61Cu]pyruvaldehyde-bis (N4-methylthiosemicarbazone) complex as a possible PET radiopharmaceutical
- Syntheses of two potential dopamine D4 receptor radioligands: 18F labelled chromeno[3,4-c]pyridin-5-ones
