Actinide uptake by transferrin and ferritin metalloproteins
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Christophe Den Auwer
Summary
In order to better understand the mechanisms of actinide uptake by specific biomolecules, it is essential to explore the intramolecular interactions between the cation and the protein binding site. Although this has long been done for widely investigated transition metals, very few studies have been devoted to complexation mechanisms of actinides by active chelation sites of metalloproteins. In this field, X-ray absorption spectroscopy has been extensively used as a structural and electronic metal cation probe. The two examples that are presented here are related to two metalloproteins in charge of iron transport and storage in eukaryote cells: transferrin and ferritin. U(VI)O22+, Np(IV) and Pu(IV) have been selected because of their possible role as contaminant from the geosphere.
© Oldenbourg Wissenschaftsverlag, München
Artikel in diesem Heft
- Preface: Chemical Speciation
- Transport methods as complementary tools for speciation purposes
- Contribution of hyphenated CE-ICP/MS in metal/protein interactions studies
- Interfacing capillary electrophoresis with inductively coupled plasma mass spectrometry for redox speciation of plutonium
- Preliminary speciation study of Co(II)-citrate system by ion pairing-reversed phase chromatography coupled to UV detector
- Resistance, accumulation and transformation of selenium by the cyanobacterium Synechocystis sp. PCC 6803 after exposure to inorganic SeVI or SeIV
- Uranium(VI) complexation in cell culture medium: influence of speciation on Normal Rat Kidney (NRK-52E) cell accumulation
- Actinide uptake by transferrin and ferritin metalloproteins
- Plutonium speciation affected by environmental bacteria
- Influence of thermodynamic database on the modelisation of americium(III) speciation in a simulated biological medium
- The OECD/NEA TDB review of selected organic ligands
Artikel in diesem Heft
- Preface: Chemical Speciation
- Transport methods as complementary tools for speciation purposes
- Contribution of hyphenated CE-ICP/MS in metal/protein interactions studies
- Interfacing capillary electrophoresis with inductively coupled plasma mass spectrometry for redox speciation of plutonium
- Preliminary speciation study of Co(II)-citrate system by ion pairing-reversed phase chromatography coupled to UV detector
- Resistance, accumulation and transformation of selenium by the cyanobacterium Synechocystis sp. PCC 6803 after exposure to inorganic SeVI or SeIV
- Uranium(VI) complexation in cell culture medium: influence of speciation on Normal Rat Kidney (NRK-52E) cell accumulation
- Actinide uptake by transferrin and ferritin metalloproteins
- Plutonium speciation affected by environmental bacteria
- Influence of thermodynamic database on the modelisation of americium(III) speciation in a simulated biological medium
- The OECD/NEA TDB review of selected organic ligands
