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Synthesis of functionalized mesoporous silica hybrid nanoparticles for controlled drug delivery under pH-stimuli

  • Anandhu Mohan , Madhappan Santhamoorthy , Ranganathan Suresh ORCID logo , Munusamy Ashwini , Natarajan Arumugam , Abdulrahman I. Almansour , Loganathan Guganathan , Tamiloli Devendhiran , Mei-Ching Lin , Seong-Cheol Kim , Keerthika Kumarasamy EMAIL logo and Thi Tuong Vy Phan EMAIL logo
Published/Copyright: May 5, 2025
Zeitschrift für Physikalische Chemie
From the journal Zeitschrift für Physikalische Chemie Volume 239 Issue 8

Abstract

This work describes the synthesis of periodic mesoporous organosilica (PMO@Py NPs) nanocarriers that integrate the hydroxyl-pyridyl (HP) ligand and could be used as an efficient drug delivery system in the presence of varying pH stimuli. PMO@Py NPs were produced by adapting the sol-gel co-condensation process. X-ray diffraction (XRD), Fourier-transform infrared (FTIR), N2 adsorption-desorption analysis, particle size analysis, and zeta potential measurements were used to characterize the produced PMO@Py NPs. The developed silica nanocarriers’ surface morphology was observed by scanning electron microscopy (SEM) study. The content of integrated organic functional groups in the PMO@Py NPs was determined using elemental analysis and thermogravimetric (TG) analysis. To ascertain the loading and pH-responsive release efficiency of the PMO@Py NPs under various pH (pH 7.4, 6.2, and 4.5) circumstances, respectively, the hydrophilic anticancer agent 5-Fu was utilized as a model drug. Furthermore, in MDA-MB-231 cells, the biocompatibility of the PMO@Py NPs was assessed. Additionally, utilizing samples of red blood cells, produced PMO@Py NPs’ hemocompatibility was assessed and compared with that of the positive control, Triton-X. Overall, the results showed that the HP-PMO@Py NPs that have been generated are biocompatible, have a high drug loading capacity (about 85 %), and release the drugs that were loaded under different pH stimulation conditions.

Keywords: periodic mesoporous silica; co-condensation technique; hydroxy-pyridyl ligand; drug delivery; biocompatibility
Corresponding authors: Keerthika Kumarasamy, Department of Applied Chemistry, Chaoyang University of Technology, Taichung, 413310, Taiwan, ROC, E-mail: ; and Thi Tuong Vy Phan, Center for Advanced Chemistry, Institute of Research and Development, Duy Tan University, 03 Quang Trung, Hai Chau, Danang, 550000, Vietnam; and Faculty of Environmental and Chemical Engineering, Duy Tan University, 03 Quang Trung, Hai Chau, Danang, 550000, Vietnam, E-mail:
Anandhu Mohan, Madhappan Santhamoorthy, and Ranganathan Suresh contributed equally to this work.

Acknowledgments

This project was carried out with the support of the “2024 System Semiconductor Technology Development Support Project” of Chungbuk Technopark. The project was funded by Researchers Supporting Project number (RSP2025R143), King Saud University, Riyadh, Saudi Arabia.

  1. Research ethics: Not applicable.

  2. Informed consent: Not applicable.

  3. Author contributions: Anandhu Mohan, Munusamy Ashwini, Madhappan Santhamoorthy, Ranganathan Suresh, Nataraj Arumugam, Loganathan Guganathan, Tamiloli Devendhiran: Conceptualization, Methodology, Characterization and data analysis, original draft writing. Mei-Ching Lin, Keerthika Kumarasamy, Mei-Ching Lin, Thi Tuong vy Phan: Data curation and rearrangement, Draft revising. Abdulrahman I. Almansour, Seong-Cheol Kim: Supervision, review, and editing.

  4. Use of Large Language Models, AI and Machine Learning Tools: The authors declares that have not used any AI-based tools.

  5. Conflict of interest: The authors have no conflicts to declare.

  6. Research funding: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2020R1I1A3052258). The project was funded by Researchers Supporting Project number (RSP2024R143), King Saud University, Riyadh, Saudi Arabia.

  7. Data availability: Data availability on request.

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Received: 2024-03-15
Accepted: 2025-04-11
Published Online: 2025-05-05
Published in Print: 2025-08-26

© 2025 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/zpch-2024-0773
Keywords for this article
periodic mesoporous silica; co-condensation technique; hydroxy-pyridyl ligand; drug delivery; biocompatibility

Articles in the same Issue

  1. Frontmatter
  2. Contributions to “Materials for solar water splitting”
  3. Synthesis and spectroscopic characterization with topology analysis, drug-likeness (ADMET), and molecular docking of novel antitumor molecule 5-Amino-3-(4-hydroxy-3-methoxyphenyl)-1-isonicotinoyl-2,3-dihydro-1H-pyrazole-4-carbonitrile
  4. Probing structural, surface morphological, optical, low temperature magnetic studies and electrochemical studies on gadolinium tellurite (GdTeO3)
  5. Nanostructured bismuth chloride based ((CH3NH3)3Bi2IxCl9-x) active layers for lead-free perovskite solar cells
  6. Structural, morphological and dielectric properties of Ni-doped ZnO nanoceramics prepared by Sol-gel method
  7. The impact of additives and dope composition on hollow fiber ultrafiltration membrane for pure water permeability
  8. Third-order nonlinear optical characteristics of natural dye anthocyanin extracted from Ixora coccinea
  9. Dimethylsulfoxide functionalized cadmium sulfide quantum dot for heavy metal ion detection
  10. Synthesis of functionalized mesoporous silica hybrid nanoparticles for controlled drug delivery under pH-stimuli
  11. Editorial
  12. Editorial epilog on the special issue “solar water splitting and artificial photosynthesis (SWAP)”
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