Abstract
Globally, cancer is the top cause of mortality, placing a heavy load on the medical system. One of the first known secondary metabolites is curcumin, a bioactive substance. This study aims to emphasize the chemopreventive and chemotherapeutic properties of curcumin and its derivatives, therefore, offering important insights for the possible creation of certain supplemental medications for the treatment of different cancers. Electronic Google databases, including Google scholar, ResearchGate, PubMed/Medline, and ScienceDirect, were searched to gather pertinent data about the chemopreventive and chemotherapeutic effects of curcumin and its derivatives. Various studies have revealed a diverse array of significant biological effects. The majority of investigations pertaining to the potential anticancer effects and associated processes are currently in the experimental preclinical stage and lack sufficient clinical trial data to validate their findings. Clinical research is further needed to clarify the molecular processes and specific targeted action of curcumin and its derivatives, as well as their potential for toxicity and side effects in humans, in order to open up new therapeutic avenues for treating cancer.
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Research ethics: Not applicable.
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Informed consent: Not applicable.
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Author contributions: All authors were involved in writing and reviewing of this article. The authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Use of Large Language Models, AI and Machine Learning Tools: None declared.
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Conflict of interest: The authors state no conflict of interest.
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Research funding: No funding received for this article.
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Data availability: Not applicable.
Abbreviations
- ACS
-
American Cancer Society
- NCI
-
National Cancer Institute
- ASVD
-
arteriosclerotic vascular disease
- DHC
-
dihydrocurcumin
- THC
-
tetrahydrocurcumin
- DNA
-
deoxyribonucleic acid
- pH
-
potential of hydrogen
- CIN
-
cervical intraepithelial neoplasia
- 5-LOX
-
5-lipoxygenase
- COX-2
-
cyclooxygenase-2
- TNF-α
-
NF-κB, tumor necrosis factor
- IFN
-
interferon
- PI3K
-
phosphoinositide 3-kinase
- AP-1
-
activator protein-1
- HER-2
-
Human epidermal growth factor receptor-2
- EGFR
-
epidermal growth factor receptor
- FGF
-
fibroblast growth factors
- TGF
-
transforming growth factors
- VEGF
-
vascular endothelial growth factor
- MMP-9
-
matrix metalloproteinase-9
- ΗIAP
-
X-linked inhibitor of apoptosis protein
- cIAP1
-
cellular inhibitor of apoptosis protein 1
- DR4
-
death receptor 4
- AMPK
-
adenosine monophosphate-activated protein kinase
- HO-1
-
heme oxygenase-1
- AST
-
aspartate transaminase
- ET-1
-
endothelin-1
- mRNA
-
messenger ribonucleic acid
- RD
-
radiation dermatitis
- PTHrP
-
parathyroid hormone-related protein
- PGV-1
-
Pentagamavunon-1
- ROS
-
reactive oxygen species
- PDT
-
Photodynamic treatment
- ROS
-
reactive oxygen species
- HPV
-
human papillomavirus
- PCR
-
concentration; polymerase chain reaction
- CSCs
-
cancer stem cells
- mTOR
-
mechanistic target of rapamycin
- PKC-θ
-
protein kinase C-theta
- NSCLC
-
nonsmall-cell lung cancer
- SCLC
-
small-cell lung cancer
- AUC
-
area under the curve
- CPN
-
nanoparticles of polylactic-co-glycolic acid called curcumin
- CUR-MPEG-PLA
-
micelles of curcumin MPEG-PLA
- CUR-NC
-
nanocrystals of curcumin
- DL
-
drug loading
- DMSO
-
dimethyl sulfide
- DR
-
drug release
- EE
-
encapsulation efficiency
- ExoCUR
-
exosomal curcumin
- HD
-
hydrodynamic diameter
- I.V
-
injection by intravenous
- LN-CUR
-
lipidic nanoparticles of curcumin
- MRT
-
mean residence time
- CM
-
MPEG–PCL curcumin micelle
- PCNA
-
proliferating cell nuclear antigen of rabbit against mouse
- PI
-
polydispersion index
- PDI T1/2
-
time of half-life
- TI
-
tumor intake
- TG
-
tumor growth
- TGI
-
tumor growth inhibition
- TIR
-
tumor inhibition rate
- ZP
-
zeta potential
- TV
-
tumor volume
- TW
-
tumor weight
- TAV
-
type A influenza virus
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Articles in the same Issue
- Frontmatter
- Review Articles
- Potential of curcumin and its derivatives, modern insights on the anticancer properties: a comprehensive overview
- Sphingolipids in medicinal mushrooms: structural insights, biological activities, and therapeutic potential
- Native/modified dextran-based nanogel in delivering drug and management of ocular complications: a review
- From current landscape to future horizon in stem cell therapy for tissue regeneration and wound healing: bridging the gap
- Research Articles
- Unveiling of the novel benzothiazole derived thiazolidinone derivatives: in vitro and in silico insights to design a promising agent for anti-Alzheimer’s disease
- Chemometric study of the effects of the geographical origin and the collection period on the chemical compositions and the antimicrobial activities of Pituranthos tortuosus essential oils
- In vitro antibacterial, DPPH radical scavenging activities, and in silico studies of isolated compounds from Rubus apetalus leaves extract
- Synthesis of benzimidazole-based hydrazones as potential anticarbonic anhydrase agents: a theoretical and experimental investigations
- Rapid Communication
- Chemical composition, anticholinesterase activity and cytotoxicity of the essential oil of Luvunga scandens (Roxb.) Wight from Malaysia
Articles in the same Issue
- Frontmatter
- Review Articles
- Potential of curcumin and its derivatives, modern insights on the anticancer properties: a comprehensive overview
- Sphingolipids in medicinal mushrooms: structural insights, biological activities, and therapeutic potential
- Native/modified dextran-based nanogel in delivering drug and management of ocular complications: a review
- From current landscape to future horizon in stem cell therapy for tissue regeneration and wound healing: bridging the gap
- Research Articles
- Unveiling of the novel benzothiazole derived thiazolidinone derivatives: in vitro and in silico insights to design a promising agent for anti-Alzheimer’s disease
- Chemometric study of the effects of the geographical origin and the collection period on the chemical compositions and the antimicrobial activities of Pituranthos tortuosus essential oils
- In vitro antibacterial, DPPH radical scavenging activities, and in silico studies of isolated compounds from Rubus apetalus leaves extract
- Synthesis of benzimidazole-based hydrazones as potential anticarbonic anhydrase agents: a theoretical and experimental investigations
- Rapid Communication
- Chemical composition, anticholinesterase activity and cytotoxicity of the essential oil of Luvunga scandens (Roxb.) Wight from Malaysia