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Sphingolipids in medicinal mushrooms: structural insights, biological activities, and therapeutic potential

  • Yhiya Amen ORCID logo EMAIL logo , Ahmed Othman ORCID logo und Kuniyoshi Shimizu ORCID logo
Veröffentlicht/Copyright: 1. Mai 2025
Zeitschrift für Naturforschung C
Aus der Zeitschrift Zeitschrift für Naturforschung C Band 81 Heft 1-2

Abstract

Edible mushrooms are well-known for their nutritional value, serving as rich sources of bioactive nutrients, mainly proteins, carbohydrates, lipids, vitamins, and minerals that are vital for human health. Lipids, integral to biological functions such as cellular structure and energy storage, play crucial roles in mushrooms’ bioactivity. Sphingolipids, an important class of lipids, serve not only as structural elements in cell membranes but also act as bioactive molecules, playing key roles in cancer prevention, skin health, and infection control. Recent studies highlight their unique presence in mushrooms. Despite their relatively low abundance, sphingolipids in mushrooms are pivotal in cellular processes and offer therapeutic potential. Advances in analytical techniques have facilitated the characterization of these compounds. This review explores the structural profiles, biological activities, and therapeutic applications of sphingolipids in medicinal mushrooms, highlighting their potential in the development of functional foods and novel therapeutic agents.

Keywords: sphingolipids; lipid extraction; ceramides; mushrooms; lipidomic profiling
Corresponding author: Yhiya Amen, Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt, E-mail:

  1. Research ethics: Not applicable.

  2. Informed consent: Not applicable.

  3. Author contributions: Yhiya Amen: conceptualization. Yhiya Amen and Ahmed Othman: data collection, analysis of reports, and preparation of the manuscript draft. Kuniyoshi Shimizu: reviewing, editing, and approving the final manuscript.

  4. Use of Large Language Models, AI and Machine Learning Tools: None declared.

  5. Conflict of interest: The authors state no conflict of interest.

  6. Research funding: None declared.

  7. Data availability: Not applicable.

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Received: 2024-09-24
Accepted: 2025-04-15
Published Online: 2025-05-01
Published in Print: 2026-01-29

© 2025 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Review Articles
  3. Potential of curcumin and its derivatives, modern insights on the anticancer properties: a comprehensive overview
  4. Sphingolipids in medicinal mushrooms: structural insights, biological activities, and therapeutic potential
  5. Native/modified dextran-based nanogel in delivering drug and management of ocular complications: a review
  6. From current landscape to future horizon in stem cell therapy for tissue regeneration and wound healing: bridging the gap
  7. Research Articles
  8. Unveiling of the novel benzothiazole derived thiazolidinone derivatives: in vitro and in silico insights to design a promising agent for anti-Alzheimer’s disease
  9. Chemometric study of the effects of the geographical origin and the collection period on the chemical compositions and the antimicrobial activities of Pituranthos tortuosus essential oils
  10. In vitro antibacterial, DPPH radical scavenging activities, and in silico studies of isolated compounds from Rubus apetalus leaves extract
  11. Synthesis of benzimidazole-based hydrazones as potential anticarbonic anhydrase agents: a theoretical and experimental investigations
  12. Rapid Communication
  13. Chemical composition, anticholinesterase activity and cytotoxicity of the essential oil of Luvunga scandens (Roxb.) Wight from Malaysia
https://doi.org/10.1515/znc-2024-0206
Schlagwörter für diesen Artikel
sphingolipids; lipid extraction; ceramides; mushrooms; lipidomic profiling

Artikel in diesem Heft

  1. Frontmatter
  2. Review Articles
  3. Potential of curcumin and its derivatives, modern insights on the anticancer properties: a comprehensive overview
  4. Sphingolipids in medicinal mushrooms: structural insights, biological activities, and therapeutic potential
  5. Native/modified dextran-based nanogel in delivering drug and management of ocular complications: a review
  6. From current landscape to future horizon in stem cell therapy for tissue regeneration and wound healing: bridging the gap
  7. Research Articles
  8. Unveiling of the novel benzothiazole derived thiazolidinone derivatives: in vitro and in silico insights to design a promising agent for anti-Alzheimer’s disease
  9. Chemometric study of the effects of the geographical origin and the collection period on the chemical compositions and the antimicrobial activities of Pituranthos tortuosus essential oils
  10. In vitro antibacterial, DPPH radical scavenging activities, and in silico studies of isolated compounds from Rubus apetalus leaves extract
  11. Synthesis of benzimidazole-based hydrazones as potential anticarbonic anhydrase agents: a theoretical and experimental investigations
  12. Rapid Communication
  13. Chemical composition, anticholinesterase activity and cytotoxicity of the essential oil of Luvunga scandens (Roxb.) Wight from Malaysia
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