From current landscape to future horizon in stem cell therapy for tissue regeneration and wound healing: bridging the gap
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Kashvy R. Morakhia
,
Aayushi C. Shah
,
Mannat P. Patel
,
Jainam K. Shah
,
Rajanikant Patel
and
Mehul R. Chorawala
Abstract
Stem cell therapy has emerged as a groundbreaking approach in regenerative medicine, offering immense potential for tissue regeneration and wound healing. Stem cells, with their ability to self-renew and differentiate into specialized cell types, provide innovative therapeutic strategies for variety of medical conditions. Key stem cell types, including embryonic, induced pluripotent, and adult stem cells such as mesenchymal and hematopoietic stem cells, play pivotal roles in regenerative processes and wound repair. In tissue regeneration, stem cells replenish damaged or necrotic cells by differentiating into specialized cell types like bone, muscle, or nerve cells, thus restoring the structural and functional integrity of tissues. In wound healing, stem cells stimulate angiogenesis, generate new skin cells, and modulate immune responses to enhance repair. This multifaceted therapeutic potential has paved the way for clinical applications in cardiovascular, neurological, musculoskeletal, and autoimmune disorders, as well as skin and burn injuries. This review highlights recent advancements in stem cell therapy, exploring its clinical applications and addressing challenges such as immune rejection, ethical concerns, scalability, and the need for long-term clinical trials. The article underscores the importance of continued research to fully realize the transformative potential of stem cell therapy in modern medicine.
Acknowledgments
The authors are grateful to Prof. Gaurang B. Shah, Department of Pharmacology, L. M. College of Pharmacy, Ahmedabad, Gujarat, India for kind support and guidance in manuscript preparation. The authors also extend their appreciation to L. M. College of Pharmacy, Ahmedabad, India for providing continuous library resources support throughout literature survey and data collection. The authors are also thankful to Sharaman Sci-Med Writing Association, India for designing Figure 4 and providing continuous support for improvising all figures dpi during revision 1.
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Research ethics: Not applicable.
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Informed consent: Not applicable.
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Author contributions: KRM, ACS – Manuscript original first draft preparation and subsequent editing, Literature and data survey, Figures; MPP, JKS – Data acquisition and curation, Tables, Graphical abstract; RP – Definition of intellectual content, Manuscript draft review and editing, Validation of acquired data, Referencing; MRC – Review topic conception, Design of content and skeleton, Manuscript draft review, editing and approval; Figures and Tables conception, Overall monitoring and co-ordination.
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Use of Large Language Models, AI and Machine Learning Tools: We confirm that no generative AI, large language models (LLMs), or machine learning tools were used in the writing, editing, or analysis of the manuscript content. All authors contributed intellectually and manually to the preparation of the manuscript.
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Conflicts of interest: The authors declare no conflict of interest to report.
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Research funding: The authors declare that no funds, grants, or other support have been received during or for the preparation of this manuscript.
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Data availability: As our manuscript is review article, no new data were created or analyzed in this study. Data sharing does not apply to this article. However, the datasets/tables/figures generated during during the preparation of current manuscript are available from the corresponding author on reasonable request.
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Supplementary Materials: No available.
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