Startseite Crotofoligandrin, a new endoperoxide crotofolane-type diterpenoid from the twigs of Croton oligandrus Pierre ex. Hutch (Euphorbiaceae)
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Crotofoligandrin, a new endoperoxide crotofolane-type diterpenoid from the twigs of Croton oligandrus Pierre ex. Hutch (Euphorbiaceae)

  • Vanneck Bedel Tatsinda Tsapi , Yannick Stéphane Fotsing Fongang ORCID logo EMAIL logo , Angelbert Fusi Awantu ORCID logo , Jean Jules Kezetas Bankeu , Mehreen Lateef , Jean Rodolphe Chouna ORCID logo EMAIL logo , Pépin Nkeng-Efouet-Alango , Muhammad Shaiq Ali und Bruno Ndjakou Lenta
Veröffentlicht/Copyright: 22. Februar 2023
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Abstract

Crotofoligandrin (1), a new endoperoxide crotofolane-type diterpenoid was isolated from the dichloromethane/methanol (1:1) extract of the twigs of Croton oligandrus Pierre Ex Hutch along with thirteen known secondary metabolites including 1-nonacosanol (2), lupenone (3), friedelin (4), β-sitosterol (5), taraxerol (6), (−)-hardwickiic acid (7), apigenin (8), acetyl aleuritolic acid (9), betulinic acid (10), fokihodgin C 3-acetate (11), D-mannitol (12), scopoletin (13) and quercetin (14). The structures of the isolated compounds were determined based on their spectroscopic data. The crude extract and the isolated compounds were assessed in vitro for their antioxidant, lipoxygenase, butyrylcholinesterase (BChE), urease and glucosidase inhibitory potentials. Compounds 1–3, and 10 displayed activities on all the performed bioassays. All the tested samples showed strong to significant antioxidant activity with compound 1 being the most potent (IC50 39.4 μM).

Keywords: crotofolane; Croton oligandrus ; endoperoxide; Euphorbiaceae
Corresponding authors: Yannick Stéphane Fotsing Fongang, Department of Chemistry, Higher Teachers’ Training College, The University of Maroua, P.O. Box 55 Maroua, Cameroon, E-mail: ; and Jean Rodolphe Chouna, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon, E-mail:

Funding source: Academy of Sciences for the Developing World

Award Identifier / Grant number: 3240293181

Funding source: Deutscher Akademischer Austauschdienst

Award Identifier / Grant number: 57316173

Acknowledgments

The authors are grateful to Dr. Tacham Walter Ndam, Botanist in the Department of Biological Sciences, Faculty of Science, at The University of Bamenda for the plant collection. The authors are also thankful to all the NMR and MS technicians of the ICCBS and Bielefeld for data recording.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: This research was funded by The World Academy of Sciences (TWAS) that financed a research stay of Y. S. F. Fongang at the International Center for Chemical and Biological Sciences (ICCBS) in Pakistan [grant FR Number: 3240293181] and the German Academic Exchange Service (DAAD) through the Yaoundé-Bielefeld School of Natural Products with Anti-parasitic and Antibacterial Activities [YaBiNaPA Project n° 57316173].

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/znc-2022-0204).

Received: 2022-10-13
Accepted: 2023-01-26
Published Online: 2023-02-22
Published in Print: 2023-07-26

© 2023 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Research Articles
  3. Proximate analysis and fatty acid, mineral and soluble carbohydrate profiles of some brown macroalgae collected from Türkiye coasts
  4. Structure elucidation of an aspidofractinine-type monoterpene indole alkaloid from Melodinus reticulatus
  5. Crotofoligandrin, a new endoperoxide crotofolane-type diterpenoid from the twigs of Croton oligandrus Pierre ex. Hutch (Euphorbiaceae)
  6. Chemical composition of different plant part from Lactuca serriola L. – focus on volatile compounds and fatty acid profile
  7. Essential oil composition, anti-tyrosinase activity, and molecular docking studies of Knema intermedia Warb. (Myristicaceae)
  8. Isolation of compounds from the roots of Ambrosia artemisiifolia and their effects on human cancer cell lines
  9. Berberine may provide redox homeostasis during aging in rats
  10. The search for commercial sweet white lupin (Lupinus albus L.) adaptive to Ethiopian growing condition seems not successful: what should be done?
https://doi.org/10.1515/znc-2022-0204
Schlagwörter für diesen Artikel
crotofolane; Croton oligandrus; endoperoxide; Euphorbiaceae

Artikel in diesem Heft

  1. Frontmatter
  2. Research Articles
  3. Proximate analysis and fatty acid, mineral and soluble carbohydrate profiles of some brown macroalgae collected from Türkiye coasts
  4. Structure elucidation of an aspidofractinine-type monoterpene indole alkaloid from Melodinus reticulatus
  5. Crotofoligandrin, a new endoperoxide crotofolane-type diterpenoid from the twigs of Croton oligandrus Pierre ex. Hutch (Euphorbiaceae)
  6. Chemical composition of different plant part from Lactuca serriola L. – focus on volatile compounds and fatty acid profile
  7. Essential oil composition, anti-tyrosinase activity, and molecular docking studies of Knema intermedia Warb. (Myristicaceae)
  8. Isolation of compounds from the roots of Ambrosia artemisiifolia and their effects on human cancer cell lines
  9. Berberine may provide redox homeostasis during aging in rats
  10. The search for commercial sweet white lupin (Lupinus albus L.) adaptive to Ethiopian growing condition seems not successful: what should be done?
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