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Berberine may provide redox homeostasis during aging in rats

  • Arun Kumar Yadawa , Parisha Srivastava , Akanksha Singh , Rashmi Kesherwani , Sukanya Bhoumik , Raushan Kumar , Jitendra Kumar Arya and Syed Ibrahim Rizvi ORCID logo EMAIL logo
Published/Copyright: April 17, 2023
Zeitschrift für Naturforschung C
From the journal Zeitschrift für Naturforschung C Volume 78 Issue 7-8

Abstract

Aging is a natural phenomenon, which is characterised by progressive physiological changes at cellular and organ level. During aging, the defence mechanism of an organism declines over the period of time. The aim of this study was to investigate the biological efficacy of berberine in D-galactose induced aging rat models. For the study, rats were divided into four groups: Control received only vehicle, BBR received berberine orally, D-Gal received D-galactose subcutaneously and BBR + D-Gal received D-galactose and berberine simultaneously. D-galactose treatment increased the pro-oxidants such as malondialdehyde (MDA) level, protein carbonyl, plasma membrane redox system (PMRS) and advanced oxidation protein products (AOPP) in the erythrocytes or plasma. It reduced the anti-oxidant level such as reduced glutathione (GSH), ferric reducing ability of plasma (FRAP), plasma thiols, sialic acid and membrane transporters like Na+/K+ ATPase and Ca2+ ATPase activity in the erythrocyte membrane. Co-treatment of berberine in D-galactose induced aging rat models restored pro-oxidants and anti-oxidants in erythrocytes. Berberine also restored the activity of Na+/K+ ATPase and Ca2+ ATPase in the erythrocyte membrane. On the basis of these findings, we suggest that berberine treatment could attenuate erythrocyte aging in rats through stabilisation of the redox equilibrium.

Keywords: aging; berberine; D-galactose; erythrocyte aging; oxidative stress
Corresponding author: Syed Ibrahim Rizvi, Department of Biochemistry, University of Allahabad, Allahabad, 211002, India, E-mail:

Acknowledgements

Authors are thankful to University Grant Commission, India for providing Dr. DS Kothari Postdoctoral Fellowship to Dr. Arun Kumar Yadawa. Authors also acknowledge the Department of Biotechnology, Government of India for providing financial support under the “Research Resources, Service Facilities, and Platforms” program.

  1. Author contributions: SIR designed the experiments, interpreted the results and critically reviewed the manuscript. AKY designed and performed the experiments, analysed the data, interpreted the results and wrote the manuscript. RK, RK, SB, JKA, PS and AS performed the experiments.

  2. Research funding: This experimental work was financially supported by University Grant Commission, India in the form of Dr. DS Kothari fellowship (No. F.4-2/2006 (BSR)/BL/19-20/0240; dated 23.06.2020) to Dr. Arun Kumar Yadawa.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

  4. Data availability statement: Data generated or analyzed during this study are provided in full within the published article.

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Received: 2022-10-29
Accepted: 2023-03-21
Published Online: 2023-04-17
Published in Print: 2023-07-26

© 2023 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Research Articles
  3. Proximate analysis and fatty acid, mineral and soluble carbohydrate profiles of some brown macroalgae collected from Türkiye coasts
  4. Structure elucidation of an aspidofractinine-type monoterpene indole alkaloid from Melodinus reticulatus
  5. Crotofoligandrin, a new endoperoxide crotofolane-type diterpenoid from the twigs of Croton oligandrus Pierre ex. Hutch (Euphorbiaceae)
  6. Chemical composition of different plant part from Lactuca serriola L. – focus on volatile compounds and fatty acid profile
  7. Essential oil composition, anti-tyrosinase activity, and molecular docking studies of Knema intermedia Warb. (Myristicaceae)
  8. Isolation of compounds from the roots of Ambrosia artemisiifolia and their effects on human cancer cell lines
  9. Berberine may provide redox homeostasis during aging in rats
  10. The search for commercial sweet white lupin (Lupinus albus L.) adaptive to Ethiopian growing condition seems not successful: what should be done?
https://doi.org/10.1515/znc-2022-0213
Keywords for this article
aging; berberine; D-galactose; erythrocyte aging; oxidative stress

Articles in the same Issue

  1. Frontmatter
  2. Research Articles
  3. Proximate analysis and fatty acid, mineral and soluble carbohydrate profiles of some brown macroalgae collected from Türkiye coasts
  4. Structure elucidation of an aspidofractinine-type monoterpene indole alkaloid from Melodinus reticulatus
  5. Crotofoligandrin, a new endoperoxide crotofolane-type diterpenoid from the twigs of Croton oligandrus Pierre ex. Hutch (Euphorbiaceae)
  6. Chemical composition of different plant part from Lactuca serriola L. – focus on volatile compounds and fatty acid profile
  7. Essential oil composition, anti-tyrosinase activity, and molecular docking studies of Knema intermedia Warb. (Myristicaceae)
  8. Isolation of compounds from the roots of Ambrosia artemisiifolia and their effects on human cancer cell lines
  9. Berberine may provide redox homeostasis during aging in rats
  10. The search for commercial sweet white lupin (Lupinus albus L.) adaptive to Ethiopian growing condition seems not successful: what should be done?
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