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Phytochemical analysis, antioxidant, cytotoxic, and antimicrobial activities of golden chamomile (Matricaria aurea (Loefl.) Schultz Bip)

  • Fatemeh Yousefbeyk , Ghazaleh Hemmati , Ziba Gholipour , Saeed Ghasemi , Mehdi Evazalipour , Clara Schubert , Diba E. Koohi and Volker Böhm ORCID logo EMAIL logo
Published/Copyright: March 1, 2022
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Zeitschrift für Naturforschung C
From the journal Zeitschrift für Naturforschung C Volume 77 Issue 7-8

Abstract

Matricaria aurea (Loefl.) Schultz Bip. (Asteraceae), known as golden chamomile, has been traditionally used for the treatment of various diseases. In this study, total phenolic, flavonoid, and tannin contents of total extract and different fractions of this plant were determined. The antioxidant, cytotoxic, and antimicrobial activities were also evaluated. Moreover, the phenolic profiles of selected fractions were determined by HPLC and LC-MS/MS analysis. Results demonstrated total phenolic contents of 37.8–57.2 mg GAE/g and total flavonoid contents of 3.0–111.2 mg QE/g. The ethyl acetate and methanol fractions (EF and MF) had the highest concentrations of phenolic, tannin, and flavonoid compounds. In both DPPH radical scavenging assay and phosphomolybdenum reduction assay, EF showed the best antioxidant activity, followed by MF. EF and MF indicated also the best antibacterial activities against Bacillus subtilis (MIC 1.56 and 12.5 mg ml−1) and Staphylococcus aureus (MIC 0.78 and 12.5 mg ml−1). Hexane fraction (HF) had no antibacterial effect. None of the samples had antifungal effect. MTT (3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay revealed for EF and HF the highest antiproliferative activities (IC50 values ranged from 111.8 to 294.6 μg ml−1). The presence of chlorogenic acid, ferulic acid, and luteolin-7-O-glucoside in MF, and p-coumaric acid in EF was confirmed and quantified.

Keywords: antibacterial activity; antioxidant activity; Asteraceae; cancerous cell lines; phenolic compounds
Corresponding author: Volker Böhm, Institute of Nutritional Sciences, Friedrich Schiller University Jena, Jena, Germany, E-mail:

Funding source: Guilan University of Medical Sciences

Award Identifier / Grant number: IR.GUMS.REC.1399.184

Acknowledgements

Thanks are given to Angelika Malarski, Institute of Nutritional Sciences, Friedrich Schiller University Jena, for technical assistance.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: This work was supported by Guilan University of Medical Sciences (Grant No. IR.GUMS.REC.1399.184 ).

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Received: 2021-10-22
Accepted: 2022-02-04
Published Online: 2022-03-01
Published in Print: 2022-07-26

© 2022 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Research Articles
  3. In vitro anticancer and antibacterial potentials of selected medicinal plants and isolation and characterization of a natural compound from Withania coagulans
  4. New compounds from Sarcophyton glaucom-derived Penicillium sp.
  5. Novel benzofurane-pyrazole derivatives with anti-inflammatory, cyclooxygenase inhibitory and cytotoxicity evaluation
  6. Evaluation and enzyme-aided enhancement of anti-photoaging properties of Camellia japonica in UVA-irradiated keratinocytes
  7. Electrochemical quantification of biomarker myeloperoxidase
  8. Scopoletin: a review of its source, biosynthesis, methods of extraction, and pharmacological activities
  9. Occurrence of Z-2-oxo-4-methyl-3-pentene-1,5-dioic acid and its regioisomer 4-methylene-2-oxo-glutaric acid in tulip tissues
  10. Phytochemical analysis, antioxidant, cytotoxic, and antimicrobial activities of golden chamomile (Matricaria aurea (Loefl.) Schultz Bip)
  11. Synthesis and characterization of silver nanoparticles using curcumin: cytotoxic, apoptotic, and necrotic effects on various cell lines
  12. Review Article
  13. A comparative analysis on the safety and efficacy of Covaxin versus other vaccines against COVID-19: a review
  14. Corrigendum
  15. Corrigendum to: an update on the progress of microbial biotransformation of commercial monoterpenes
https://doi.org/10.1515/znc-2021-0269
Keywords for this article
antibacterial activity; antioxidant activity; Asteraceae; cancerous cell lines; phenolic compounds

Articles in the same Issue

  1. Frontmatter
  2. Research Articles
  3. In vitro anticancer and antibacterial potentials of selected medicinal plants and isolation and characterization of a natural compound from Withania coagulans
  4. New compounds from Sarcophyton glaucom-derived Penicillium sp.
  5. Novel benzofurane-pyrazole derivatives with anti-inflammatory, cyclooxygenase inhibitory and cytotoxicity evaluation
  6. Evaluation and enzyme-aided enhancement of anti-photoaging properties of Camellia japonica in UVA-irradiated keratinocytes
  7. Electrochemical quantification of biomarker myeloperoxidase
  8. Scopoletin: a review of its source, biosynthesis, methods of extraction, and pharmacological activities
  9. Occurrence of Z-2-oxo-4-methyl-3-pentene-1,5-dioic acid and its regioisomer 4-methylene-2-oxo-glutaric acid in tulip tissues
  10. Phytochemical analysis, antioxidant, cytotoxic, and antimicrobial activities of golden chamomile (Matricaria aurea (Loefl.) Schultz Bip)
  11. Synthesis and characterization of silver nanoparticles using curcumin: cytotoxic, apoptotic, and necrotic effects on various cell lines
  12. Review Article
  13. A comparative analysis on the safety and efficacy of Covaxin versus other vaccines against COVID-19: a review
  14. Corrigendum
  15. Corrigendum to: an update on the progress of microbial biotransformation of commercial monoterpenes
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