New compounds from Sarcophyton glaucom-derived Penicillium sp.
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Mohamed Shaaban
Abstract
Further investigation of the residual bioactive compounds produced by the soft coral Sarcophyton glaucom-derived Penicillium sp. MMA afforded five new compounds assigned as 9-methoxy-penicyrone A (1), 9-methoxy-penicyrone B (2), 3-hydroxy-2,2,4-trimethyl-pentyl ester (3), 3-hydroxy-1-isopropyl-2,2-dimethyl-propyl ester (4), and 3-isobutyryloxy-2,2,4-trimethyl-pentyl linoleate (5). Additional six known compounds were isolated: penicyrones A–B (6, 7), 4-(2-hydroxy-3-butynoxy)benzoic acid (8), cyclopenol (9), aspermytin A (10), and aurantiomide A (11). Structures of the new compounds (1–5) were identified by 1D (1H & 13C) and 2 D (1H–1H COSY, HMBC and NOESY) NMR and HRESI-MS spectroscopic data. Biologically, the antimicrobial activities of the obtained compounds were studied as well.
Acknowledgments
The author is deeply thankful to Prof. H. Laatsch, Institute of Organic and Biomolecular Chemistry, Göttingen, for his support and lab facilities. I thank Dr. H. Frauendorf and Dr. M. John for MS and NMR measurements. I am grateful as well to F Lissy for the activity testing done in the research work. M. Shaaban thanks the German Academic Exchange Service (DAAD) for a Postdoc short-term grant.
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Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Research funding: None declared.
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Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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Supplementary Material
The online version of this article offers supplementary material (https://doi.org/10.1515/znc-2021-0236).
© 2021 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Research Articles
- In vitro anticancer and antibacterial potentials of selected medicinal plants and isolation and characterization of a natural compound from Withania coagulans
- New compounds from Sarcophyton glaucom-derived Penicillium sp.
- Novel benzofurane-pyrazole derivatives with anti-inflammatory, cyclooxygenase inhibitory and cytotoxicity evaluation
- Evaluation and enzyme-aided enhancement of anti-photoaging properties of Camellia japonica in UVA-irradiated keratinocytes
- Electrochemical quantification of biomarker myeloperoxidase
- Scopoletin: a review of its source, biosynthesis, methods of extraction, and pharmacological activities
- Occurrence of Z-2-oxo-4-methyl-3-pentene-1,5-dioic acid and its regioisomer 4-methylene-2-oxo-glutaric acid in tulip tissues
- Phytochemical analysis, antioxidant, cytotoxic, and antimicrobial activities of golden chamomile (Matricaria aurea (Loefl.) Schultz Bip)
- Synthesis and characterization of silver nanoparticles using curcumin: cytotoxic, apoptotic, and necrotic effects on various cell lines
- Review Article
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- Corrigendum
- Corrigendum to: an update on the progress of microbial biotransformation of commercial monoterpenes
Artikel in diesem Heft
- Frontmatter
- Research Articles
- In vitro anticancer and antibacterial potentials of selected medicinal plants and isolation and characterization of a natural compound from Withania coagulans
- New compounds from Sarcophyton glaucom-derived Penicillium sp.
- Novel benzofurane-pyrazole derivatives with anti-inflammatory, cyclooxygenase inhibitory and cytotoxicity evaluation
- Evaluation and enzyme-aided enhancement of anti-photoaging properties of Camellia japonica in UVA-irradiated keratinocytes
- Electrochemical quantification of biomarker myeloperoxidase
- Scopoletin: a review of its source, biosynthesis, methods of extraction, and pharmacological activities
- Occurrence of Z-2-oxo-4-methyl-3-pentene-1,5-dioic acid and its regioisomer 4-methylene-2-oxo-glutaric acid in tulip tissues
- Phytochemical analysis, antioxidant, cytotoxic, and antimicrobial activities of golden chamomile (Matricaria aurea (Loefl.) Schultz Bip)
- Synthesis and characterization of silver nanoparticles using curcumin: cytotoxic, apoptotic, and necrotic effects on various cell lines
- Review Article
- A comparative analysis on the safety and efficacy of Covaxin versus other vaccines against COVID-19: a review
- Corrigendum
- Corrigendum to: an update on the progress of microbial biotransformation of commercial monoterpenes
