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New compounds from Sarcophyton glaucom-derived Penicillium sp.

  • Mohamed Shaaban ORCID logo EMAIL logo
Published/Copyright: December 15, 2021
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Zeitschrift für Naturforschung C
From the journal Zeitschrift für Naturforschung C Volume 77 Issue 7-8

Abstract

Further investigation of the residual bioactive compounds produced by the soft coral Sarcophyton glaucom-derived Penicillium sp. MMA afforded five new compounds assigned as 9-methoxy-penicyrone A (1), 9-methoxy-penicyrone B (2), 3-hydroxy-2,2,4-trimethyl-pentyl ester (3), 3-hydroxy-1-isopropyl-2,2-dimethyl-propyl ester (4), and 3-isobutyryloxy-2,2,4-trimethyl-pentyl linoleate (5). Additional six known compounds were isolated: penicyrones A–B (6, 7), 4-(2-hydroxy-3-butynoxy)benzoic acid (8), cyclopenol (9), aspermytin A (10), and aurantiomide A (11). Structures of the new compounds (1–5) were identified by 1D (1H & 13C) and 2 D (1H–1H COSY, HMBC and NOESY) NMR and HRESI-MS spectroscopic data. Biologically, the antimicrobial activities of the obtained compounds were studied as well.

Keywords: antimicrobial activity; diverse new metabolites; soft coral-derived Penicillium sp
Corresponding author: Mohamed Shaaban, Chemistry of Natural Compounds Department, Division of Pharmaceutical Industries, National Research Centre, El-Behoos St. 33, Dokki, Cairo 12622, Egypt; and University of Göttingen, Institute of Organic and Biomolecular Chemistry, Tammannstrasse 2, D-37077, Göttingen, Germany, E-mail: .

Acknowledgments

The author is deeply thankful to Prof. H. Laatsch, Institute of Organic and Biomolecular Chemistry, Göttingen, for his support and lab facilities. I thank Dr. H. Frauendorf and Dr. M. John for MS and NMR measurements. I am grateful as well to F Lissy for the activity testing done in the research work. M. Shaaban thanks the German Academic Exchange Service (DAAD) for a Postdoc short-term grant.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/znc-2021-0236).

Received: 2021-09-05
Accepted: 2021-11-20
Published Online: 2021-12-15
Published in Print: 2022-07-26

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Research Articles
  3. In vitro anticancer and antibacterial potentials of selected medicinal plants and isolation and characterization of a natural compound from Withania coagulans
  4. New compounds from Sarcophyton glaucom-derived Penicillium sp.
  5. Novel benzofurane-pyrazole derivatives with anti-inflammatory, cyclooxygenase inhibitory and cytotoxicity evaluation
  6. Evaluation and enzyme-aided enhancement of anti-photoaging properties of Camellia japonica in UVA-irradiated keratinocytes
  7. Electrochemical quantification of biomarker myeloperoxidase
  8. Scopoletin: a review of its source, biosynthesis, methods of extraction, and pharmacological activities
  9. Occurrence of Z-2-oxo-4-methyl-3-pentene-1,5-dioic acid and its regioisomer 4-methylene-2-oxo-glutaric acid in tulip tissues
  10. Phytochemical analysis, antioxidant, cytotoxic, and antimicrobial activities of golden chamomile (Matricaria aurea (Loefl.) Schultz Bip)
  11. Synthesis and characterization of silver nanoparticles using curcumin: cytotoxic, apoptotic, and necrotic effects on various cell lines
  12. Review Article
  13. A comparative analysis on the safety and efficacy of Covaxin versus other vaccines against COVID-19: a review
  14. Corrigendum
  15. Corrigendum to: an update on the progress of microbial biotransformation of commercial monoterpenes
https://doi.org/10.1515/znc-2021-0236
Keywords for this article
antimicrobial activity; diverse new metabolites; soft coral-derived Penicillium sp

Articles in the same Issue

  1. Frontmatter
  2. Research Articles
  3. In vitro anticancer and antibacterial potentials of selected medicinal plants and isolation and characterization of a natural compound from Withania coagulans
  4. New compounds from Sarcophyton glaucom-derived Penicillium sp.
  5. Novel benzofurane-pyrazole derivatives with anti-inflammatory, cyclooxygenase inhibitory and cytotoxicity evaluation
  6. Evaluation and enzyme-aided enhancement of anti-photoaging properties of Camellia japonica in UVA-irradiated keratinocytes
  7. Electrochemical quantification of biomarker myeloperoxidase
  8. Scopoletin: a review of its source, biosynthesis, methods of extraction, and pharmacological activities
  9. Occurrence of Z-2-oxo-4-methyl-3-pentene-1,5-dioic acid and its regioisomer 4-methylene-2-oxo-glutaric acid in tulip tissues
  10. Phytochemical analysis, antioxidant, cytotoxic, and antimicrobial activities of golden chamomile (Matricaria aurea (Loefl.) Schultz Bip)
  11. Synthesis and characterization of silver nanoparticles using curcumin: cytotoxic, apoptotic, and necrotic effects on various cell lines
  12. Review Article
  13. A comparative analysis on the safety and efficacy of Covaxin versus other vaccines against COVID-19: a review
  14. Corrigendum
  15. Corrigendum to: an update on the progress of microbial biotransformation of commercial monoterpenes
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