(−)-Brunneusine, a new phenolic compound with antibacterial properties in aqueous medium from the leaves of Agelanthus brunneus (Engl.) Tiegh (LORANTHACEAE)
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Moifo Kuete Thomas Wieland
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Storr E. Thomas
Abstract
Agelanthus brunneus (Loranthaceae) is a hemiparasitic plant growing on Senna siamea (Fabaceae). The chemical investigation of its leaves and flowers led to the isolation of one new phenolic compound namely (−)-brunneusine (1), together with 13 known compounds. The crude leaves and flowers extracts (CLE and CFLE) with their ethyl acetate fractions (EAFL and EAFFL) and some isolated compounds (1–3; 8–9 and 11–14) have been tested on four bacterial species of sanitary importance isolated in an aquatic environment. All the samples except compound 3 showed antibacterial activity with MICs ranging from 0.43 to 8.88.103 µg/mL and MBCs from 0.43 to 3.55.103 µg/mL. Compounds 9 and 14 showed better activity on all bacterial species tested with MICs ranging from 0.43 to 27.77 µg/mL. Only CLE, EAFL and compounds 14, 2, 8 and 9 showed bactericidal effects on all bacterial species tested.
Funding source: UEA
Award Identifier / Grant number: CHE 21A3
Acknowledgment
B. Ngameni, S. E. Thomas and S. G. Richard acknowledge Open Lab Africa through this exchange research program. The authors are also grateful to the School of Chemistry, Faculty of Science, University of East Anglia, UK for research facilities and support with the experimental equipment and Dr. C.J. Macdonald, NMR Facility Manager, School of Chemistry for technical advice and training.
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Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Research funding: This research was supported by the UEA Vice Chancellor’s Global Challenges Research Fellowships Scheme; Code: CHE 21A3.
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Conflict of interest statement: The authors declare no conflict of interest.
HR-ESI-MS, IR as well as 1D and 2D NMR spectra of compounds 1–3; 6–14 are available as supplementary material.
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Supplementary Material
The online version of this article offers supplementary material (https://doi.org/10.1515/znc-2021-0143).
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Artikel in diesem Heft
- Frontmatter
- Research Articles
- Bioactive compounds from Matricaria chamomilla: structure identification, in vitro antiproliferative, antimigratory, antiangiogenic, and antiadenoviral activities
- Antimicrobial synergism and antibiofilm activities of Pelargonium graveolens, Rosemary officinalis, and Mentha piperita essential oils against extreme drug-resistant Acinetobacter baumannii clinical isolates
- Chemical composition, antioxidant, and antimicrobial activities of two essential oils from Algerian propolis
- Stability of proteins involved in initiation of DNA replication in UV damaged human cells
- Bioguided isolation of antiplasmodial secondary metabolites from Persea americana Mill. (Lauraceae)
- Biological activities of some Salvia species
- Secondary metabolites of downy birch buds (Betula pubescens Erch.)
- (−)-Brunneusine, a new phenolic compound with antibacterial properties in aqueous medium from the leaves of Agelanthus brunneus (Engl.) Tiegh (LORANTHACEAE)
- Novel thiazolyl-hydrazone derivatives including piperazine ring: synthesis, in vitro evaluation, and molecular docking as selective MAO-A inhibitor
Artikel in diesem Heft
- Frontmatter
- Research Articles
- Bioactive compounds from Matricaria chamomilla: structure identification, in vitro antiproliferative, antimigratory, antiangiogenic, and antiadenoviral activities
- Antimicrobial synergism and antibiofilm activities of Pelargonium graveolens, Rosemary officinalis, and Mentha piperita essential oils against extreme drug-resistant Acinetobacter baumannii clinical isolates
- Chemical composition, antioxidant, and antimicrobial activities of two essential oils from Algerian propolis
- Stability of proteins involved in initiation of DNA replication in UV damaged human cells
- Bioguided isolation of antiplasmodial secondary metabolites from Persea americana Mill. (Lauraceae)
- Biological activities of some Salvia species
- Secondary metabolites of downy birch buds (Betula pubescens Erch.)
- (−)-Brunneusine, a new phenolic compound with antibacterial properties in aqueous medium from the leaves of Agelanthus brunneus (Engl.) Tiegh (LORANTHACEAE)
- Novel thiazolyl-hydrazone derivatives including piperazine ring: synthesis, in vitro evaluation, and molecular docking as selective MAO-A inhibitor
