Benzimidazole – Schiff bases and their complexes: synthesis, anticancer activity and molecular modeling as Aurora kinase inhibitor
-
Asmaa A. Magd-El-Din
, Hanan A. Mousa
Abstract
A new series of Schiff bases containing benzіmidazole moiety 11–17 were synthesized by the reaction of 4-(1H-benzо[d]іmіdazоl-2-yl)anіline (1) with different aromatic aldehydes (4–10) via conventional heating and microwave irradiation methods. The structures of the novel Schiff bases were characterized by using different spectral data. Also, metal complexes 18–21 of compound 13 were synthesized, and their structure was confirmed by spectral measurements (IR, NMR, UV), molar conductivity, magnetic susceptibility and thermo-gravimetric analysis. The novel synthesized ligand 13 and its complexes 18–21 were tested for their in vitro antitumor activities towards breast, liver and lung cancer cell lines. Also, the acute toxicity of the prepared compounds 13 and 18–21 was determined in vivo. The results showed that the newly synthesized compounds 13 and 18–21 exhibited a significant activity against cancer, especially for complex 21, compared to standard drug doxorubicin. The molecular docking of complexes 20 and 21 has been also studied as Aurora kinase inhibitors.
Acknowledgments
The authors wish to express their thanks to the National Research Centre for the facilities provided. In addition, the authors thank Dr. Ahmed H. El-Desoky, Department of Pharmacognosy, National Research Centre, for his favorable cooperation in doing the molecular docking of the rest of the compounds.
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Articles in the same Issue
- Frontmatter
- Research Articles
- Muscle relaxant activities of pistagremic acid isolated from Pistacia integerrima
- Facile one-pot syntheses of new C-28 esters of oleanolic acid and studies on their antiproliferative effect on T cells
- Biodiversity and full genome sequence of potato viruses Alfalfa mosaic virus and potato leaf roll virus in Egypt
- Carotenoids, tocopherols, organic acids, charbohydrate and mineral content in different medicinal plant extracts
- Two new usnic acid derivatives from the endophytic fungus Mycosphaerella sp.
- Antimicrobial activity and active compounds of a Rhus verniciflua Stokes extract
- Benzimidazole – Schiff bases and their complexes: synthesis, anticancer activity and molecular modeling as Aurora kinase inhibitor
Articles in the same Issue
- Frontmatter
- Research Articles
- Muscle relaxant activities of pistagremic acid isolated from Pistacia integerrima
- Facile one-pot syntheses of new C-28 esters of oleanolic acid and studies on their antiproliferative effect on T cells
- Biodiversity and full genome sequence of potato viruses Alfalfa mosaic virus and potato leaf roll virus in Egypt
- Carotenoids, tocopherols, organic acids, charbohydrate and mineral content in different medicinal plant extracts
- Two new usnic acid derivatives from the endophytic fungus Mycosphaerella sp.
- Antimicrobial activity and active compounds of a Rhus verniciflua Stokes extract
- Benzimidazole – Schiff bases and their complexes: synthesis, anticancer activity and molecular modeling as Aurora kinase inhibitor